Navigation Links
NIH fellow uses computation, experimentation to study diabetes, obesity
Date:8/2/2011

221.10.254.64

Stephanie Nicole "Nikki" Lewis, a graduate student in the interdisciplinary doctoral program in genetics, bioinformatics, and computational biology at Virginia Tech, has been awarded the prestigious Ruth L. Kirschstein National Research Service Award for Predoctoral Research through the National Institutes of Health for her study of a cellular signaling receptor that is associated with chronic inflammatory diseases such as diabetes, obesity, and inflammatory bowel disease.

Lewis is applying a combination of computational modeling and experimental methods to identify molecules that can activate peroxisome proliferator activated receptor gamma (PPAR ), which is a therapeutic target for suppressing inflammation. The search for drugs targeting the receptor is urgently needed since use of current drugs to treat type II diabetes by binding to PPAR , like the recently restricted Avandia (GlaxoSmithKline), results in adverse side effects. A goal of Lewis' research is to identify novel, orally active naturally occurring compounds with therapeutic potential due to their insulin-sensitizing and anti-inflammatory actions. The computational methods are used to quickly and inexpensively screen large numbers of compounds, from which a small number are selected for experimental validation in vitro and through pre-clinical animal studies.

This project entitled "Virtual Screening Development to Complement Experimental Screening for PPAR Modulators to Treat Type II Diabetes Mellitus" is primarily funded through the National Institute of Diabetes and Digestive and Kidney Diseases of NIH.

Lewis is working jointly with David Bevan, professor of biochemistry in the College of Agriculture and Life Sciences, and Josep Bassaganya-Riera, associate professor in the Nutritional Immunology and Molecular Medicine Laboratory at the Virginia Bioinformatics Institute (www.modelingimmunity.org).

"The strength of Nikki's research lies not only in the combination of computational and experimental methods, but also in her approach that will unravel details of the events that accompany PPAR  activation, thereby making the drug discovery process more rational," Bevan said.

"Nikki's successful NIH proposal builds upon ongoing collaborative research between Dr. Bevan and NIMML aimed at streamlining the drug and nutraceutical discovery process. In addition, Nikki's project leverages and extends the scope of studies conducted by the Center for Modeling Immunity to Enteric Pathogens. Specifically, this effort is in line with the goal of discovering novel broad-based immune therapeutics for gastrointestinal infectious diseases by creating computational models of the mucosal immune system and sets the stage for multi-scale modeling in drug discovery," Bassaganya-Riera said.


'/>"/>

Contact: Lori Greiner
lgreiner@vt.edu
540-231-5863
Virginia Tech
Source:Eurekalert  

Related biology news :

1. Green light for EU co-funding of TUM Institute for Advanced Study fellowships
2. Damon Runyon Cancer Research Foundation awards prestigious fellowships to 18 top young scientists
3. Entomological Society of America names 2011 fellows
4. Weatherstone Fellows publish research as Autism Speaks announces 2011 Weatherstone Fellows
5. Top Latin-American scientists named 2011 Pew Fellows in the Biomedical Sciences
6. Rensselaer scholar receives NSF Research Fellowship
7. ASPB awards 15 summer undergraduate research fellowships
8. OGI awards summer research fellowships to 7 Ontario students
9. 5 UH graduates receive NSF fellowships for further study
10. Top Australian malaria researcher elected Fellow of the Royal Society
11. Fellowship to UC Riverside botanist encourages Hispanic students to take up research
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
NIH fellow uses computation, experimentation to study diabetes, obesity
(Date:1/25/2017)... , Jan. 25, 2017 The Elements ... Management (IAM) lifecycle is comprised of a comprehensive ... the purpose of maintaining digital identities and providing ... and applications. There are significant number of programs ... time to time by optimizing processes and changing ...
(Date:1/23/2017)... latest mobile market research from Acuity Market Intelligence reveals ... average price of a biometric smartphone decreased from $849 ... are now 120 sub-$150 models on the market at ... a year ago at an average price of $127. ... Acuity Market Intelligence Principal, "Biometric Smartphones are a global ...
(Date:1/19/2017)... , Jan. 19, 2017 Sensory ... experience and security for consumer electronics, and ... processing systems and cybersecurity solutions, today announced a ... and financial institutions worldwide to bolster security of ... end-to-end secure user authentication platforms they offer, innerCore ...
Breaking Biology News(10 mins):
(Date:2/16/2017)... Research and Markets has announced the addition ... to their offering. ... The study scope includes ... chassis organisms, synthetic cells, production systems), enabling technologies (DNA ... specialty media) and enabled technologies (biofuels, chemicals, pharmaceuticals, agriculture) ...
(Date:2/16/2017)...   Biostage, Inc. (Nasdaq: BSTG ... bioengineered organ implants to treat cancers and other life-threatening ... the closing on February 15, 2017 of its previously ... and warrants to purchase 20,000,000 shares of common stock, ... was priced at $0.40 per share of common stock, ...
(Date:2/16/2017)... , Feb. 16, 2017 UCHealth ( ... utilize LungDirect for pulmonary nodule patient management. In addition ... or a spot on the lung, UCHealth looks to ... manual data entry. Stephanie Brown, RN ... my nodule patients with an Excel spreadsheet, which was ...
(Date:2/16/2017)... N.J. , Feb. 16, 2017  Champions Oncology, ... in the development and sale of advanced technology solutions ... oncology drugs, today announced the addition of new cohorts ... These new models will expand Champions, product line ... head and neck cancer, AML, and non-small cell lung ...
Breaking Biology Technology: