Navigation Links
NIH expands network focused on how genes affect drug responses
Date:9/7/2010

The National Institutes of Health plans to spend $161.3 million over the next five years to expand the Pharmacogenomics Research Network (PGRN), a nationwide collaborative of scientists focused on understanding how genes affect a person's response to medicines.

"Thanks to breakthroughs in genome sequencing technologies and our growing understanding of genetic variation among individuals, there has never been a better time to propel the field of pharmacogenomics,'' said NIH Director Francis S. Collins, M.D., Ph.D. "Through these studies, we are moving closer to the goal of using genetic information to help prescribe the safest, most effective medicine for each patient."

Spearheaded by the NIH's National Institute of General Medical Sciences (NIGMS) and launched in 2000, the PGRN has already identified gene variants linked to responses to medicines for different cancers, heart disease, asthma, nicotine addiction and other conditions.

The expanded network will continue research in these areas and move into new ones, including rheumatoid arthritis and bipolar disorder. Network scientists will also develop novel research methods and study the use of pharmacogenetics in rural and underserved populations.

The new awards include 14 scientific research projects and seven network resources. The resources will benefit PGRN scientists by:

  • offering deep DNA sequencing capacity by partnering with experts in this field
  • providing statistical analysis expertise
  • developing standardized terminology for pharmacogenomics research
  • piloting ways to learn about pharmacogenomics from de-identified medical records in health care systems
  • continuing and expanding a 2-year-old international collaboration with the Center for Genomic Medicine at the RIKEN Institute in Yokohama, Japan.

Research Groups

The PGRN research group projects are listed below alphabetically by principal investigator. Also included are the anticipated five-year total costs for each grant.

    Kathleen M. Giacomini, University of California, San Francisco, $11.9 million, Pharmacogenomics of Membrane Transporters (the Global Alliance for Pharmacogenomics resource listed below is also associated with this award)

    Julie A. Johnson, University of Florida, Gainesville, $9.8 million, Pharmacogenomic Evaluation of Antihypertensive Responses

    John R. Kelsoe, University of California, San Diego, $6.4 million, Pharmacogenomics of Mood Stabilizer Response in Bipolar Disorder

    Ronald M. Krauss, Children's Hospital Oakland Research Institute (Calif.), $9.4 million, Pharmacogenomics and Risk of Cardiovascular Disease (the Human Exome Resequencing resource listed below is also associated with this award)

    Caryn Lerman, University of Pennsylvania, Philadelphia, and Rachel F. Tyndale, University of Toronto, $12 million, Pharmacogenetics of Nicotine Addiction Treatment

    Robert M. Plenge, Brigham and Women's Hospital, Boston, $7.5 million, Genetic Predictors of Response to Anti-TNF Therapy in Rheumatoid Arthritis

    Mark J. Ratain, Nancy J. Cox and M. Eileen Dolan, University of Chicago, $10.3 million, PAAR--Pharmacogenomics of Anticancer Agents Research Group

    Mary V. Relling, St. Jude Children's Research Hospital, Memphis, Tenn., $8.6 million, PAAR4Kids--Pharmacogenomics of Anticancer Agents Research in Children

    Dan M. Roden, Vanderbilt University School of Medicine, Nashville, Tenn., $12.4 million, Pharmacogenomics of Arrhythmia Therapy (two resources listed belowPGRN Statistical Analysis Resource and Pharmacogenomic Discovery and Replication in Very Large Populationsare also associated with this award)

    Wolfgang Sadee, Ohio State University, Columbus, $9.1 million, Expression Genetics in Drug Therapy

    Alan R. Shuldiner, University of Maryland, Baltimore, $11.4 million, Pharmacogenomics of Anti-Platelet Intervention-2 (PAPI-2) Study

    Kenneth E. Thummel and Wylie G. Burke, University of Washington, Seattle, $10.2 million, Pharmacogenetics in Rural and Underserved Populations

    Richard M. Weinshilboum, Mayo Clinic, Rochester, Minn., $11.2 million, Pharmacogenetics of Phase II Drug Metabolizing Enzymes (two resources listed belowNext Generation DNA Sequencing and Pharmacogenomic Ontology Network Resourceare also associated with this award)

    Scott T. Weiss and Kelan G. Tantisira, Brigham and Women's Hospital, Boston, $9.8 million, Pharmacogenetics of Asthma Treatment

Network Resources

The PGRN resources are listed below along with their anticipated five-year grant total costs. The scientists leading each effort are listed alphabetically.

    Global Alliance for Pharmacogenomics, $3.2 million
    Kathleen M. Giacomini, University of California, San Francisco

    Next Generation DNA Sequencing, $2.3 million
    Richard Gibbs, Baylor College of Medicine, Houston

    Next Generation Sequencing, $3.0 million
    Elaine Mardis, Washington University, St. Louis

    Human Exome Resequencing, $3.9 million
    Deborah A. Nickerson, University of Washington School of Medicine, Seattle

    PGRN Statistical Analysis Resource, $2.4 million
    Marylyn Ritchie, Vanderbilt University, Nashville

    Pharmacogenomic Discovery and Replication in Very Large Populations, $3.4 million
    Dan M. Roden, Vanderbilt University Medical Center, Nashville

    Pharmacogenomic Ontology Network Resource, $3.1 million
    Christopher Chute, Mayo Clinic, Rochester


'/>"/>

Contact: Alisa Zapp Machalek
alisa.machalek@nih.gov
301-496-7301
NIH/National Institute of General Medical Sciences
Source:Eurekalert

Related biology news :

1. NIH expands key pharmacogenomics resource
2. Core knowledge of tree fruit expands with apple genome sequencing
3. High-resolution imaging expands vision research of live birds of prey
4. Orbel Expands Fabric over Foam Gasket Product Line
5. HIV vaccine strategy expands immune responses
6. Identive Group Expands Executive Management Team
7. Identive Group Expands Executive Management Team
8. Nepal expands critical tiger habitat
9. ID Analytics Expands Availability of On-Demand Identity Intelligence Solutions for the Government Market
10. Fujitsu Expands Support for Ethernet Networks With New Additions to XG Switch Product Line
11. NIH expands Human Microbiome Project; funds sequencing centers and disease projects
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/15/2017)... --  ivWatch LLC , a medical device company focused on improving ... of its ISO 13485 Certification, the global standard for medical device ... (ISO®). ... Monitoring device for the early detection of IV infiltrations. ... "This is an important milestone for ivWatch, as it ...
(Date:6/14/2017)... , June 15, 2017  IBM (NYSE: IBM ) is ... tech event dedicated to developing collaboration between startups and global ... June 15-17. During the event, nine startups will showcase the ... in various industries. France ... international market, with a 30 percent increase in the number ...
(Date:5/6/2017)... May 5, 2017 RAM Group ... a new breakthrough in biometric authentication based on ... mechanical properties to perform biometric authentication. These new sensors ... material created by Ram Group and its partners. This ... transportation, supply chains and security. Ram Group is ...
Breaking Biology News(10 mins):
(Date:10/9/2017)... SAN DIEGO , Oct. 9, 2017 /PRNewswire/ ... a biological mechanism by which its ProCell stem ... of critical limb ischemia.  The Company, demonstrated that ... the amount of limbs saved as compared to ... of the molecule HGF resulted in reduction of ...
(Date:10/9/2017)... (PRWEB) , ... October 09, 2017 , ... ... a four-tiered line of medical marijuana products targeting the needs of consumers who ... packaging of Kindred takes place in Phoenix, Arizona. , As operators of two ...
(Date:10/7/2017)... , ... October 06, 2017 ... ... in Hi-C-based genomic technologies, launched its ProxiMeta™ Hi-C metagenome deconvolution product, featuring ... kit and accompanying cloud-based bioinformatics software to perform Hi-C metagenome deconvolution using ...
(Date:10/6/2017)... ... October 06, 2017 , ... On Tuesday, ... webinar on INSIGhT, the first-ever adaptive clinical trial for glioblastoma (GBM). The featured ... event is free and open to the public, but registration is required. , ...
Breaking Biology Technology: