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NIH expands key pharmacogenomics resource
Date:9/7/2010

ng tested in a large-scale clinical trial sponsored by the NIH's National Heart, Lung, and Blood Institute.

PharmGKB and other scientists also analyzed a person's entire genome, to identify variations associated with disease risk and adverse drug reactions.

During the next five years, PharmGKB plans to:

  • Develop tools that automatically extract information from the biomedical literature and key databases.

  • Intensify its focus on understanding the molecular basis for drug toxicity and multiple-drug interactions, information that may help improve the safety and efficacy of medicines.

  • Analyze the genomes of additional individuals, including a family that has volunteered to be studied.

  • Develop guidelines for doctors about the use of genetic tests to customize dosages when prescribing certain medicines.

"PharmGKB has become a powerful resource not only by providing high-quality information, but also by bringing researchers together to share ideas and collaborate," said Rochelle M. Long, Ph.D., who directs pharmacogenomics research programs at NIGMS. "We anticipate that such collaborations will continue to grow for the next five years."

PharmGKB is part of a broader NIH pharmacogenomics initiative that includes individual research projects and a nationwide research consortium, the NIH Pharmacogenomics Research Network (PGRN). New PGRN grants are also being announced at this time.


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Contact: Alisa Zapp Machalek
alisa.machalek@nih.gov
301-496-7301
NIH/National Institute of General Medical Sciences
Source:Eurekalert

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