NIH expands Human Microbiome Project; funds sequencing centers and diseas...( Digestive tract Crohn's Disease $1.1 ...)

Date:6/23/2009

Digestive tract, Crohn's Disease
$1.1 million
Crohn's Disease, a form of inflammatory bowel disease, in children is typically treated with a liquid nutrient diet. It is not known how this treatment works. This team will investigate whether it works by altering the composition of the intestinal microbiome. Partial funding for this project will be provided by NIH's Office of Dietary Supplements.

Vincent B. Young, M.D., Ph.D., University of Michigan, Ann Arbor
Digestive tract: Ulcerative Colitis
$1 million
Some patients who suffer from ulcerative colitis, a type of inflammatory bowel disease that causes inflammation and sores in the lining of the rectum and colon, are treated with surgical removal of the colon, followed by construction of a pouch to assist the patient with bowel movements. For unknown reasons, some, patients develop inflammation of the pouch, necessitating further surgery. This research will determine whether the composition of the pouch microbiome influences the onset and progression of pouch inflammation.

Each pilot demonstration project will be reviewed after one year to evaluate its progress toward milestones, as well as its ability to demonstrate a definable relationship between a body site microbiome and disease.

In the first phases of the Human Microbiome Project, jumpstart funding was awarded to create a framework and data resources. Funding has also previously been awarded for the development of innovative technologies and computational tools, coordination of data analysis, and an examination of some of the ethical, legal and social implications of human microbiome research.

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Contact: Geoffrey Spencer spencerg@mail.nih.gov 301-402-0911 NIH/National Human Genome Research Institute Source:Eurekalert

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