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NIH expands Human Microbiome Project; funds sequencing centers and disease projects
Date:6/23/2009

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J. Dennis Fortenberry, M.D., Indiana University Purdue University at Indianapolis
Male urethra: Puberty, Sexual Activity and Sexually Transmitted Diseases
$820,000
Samples will be collected from an ethnically diverse group of male adolescents to characterize the male urethral microbiome and its relation to puberty, sexual activity and sexually transmitted disease.

Claire M. Fraser-Liggett, Ph.D., University of Maryland School of Medicine, Baltimore (two grants)
Digestive tract: Obesity
$1 million
This study will sample the gut microbiome from obese and non-obese subjects from the Amish population to uncover associations with metabolism, inflammation, and other traits related to obesity. It will also study the influence of human genetic variation on the composition of the microbiome.

Digestive tract: Crohn's Disease
$1 million
The relationship between the inflammatory bowel disease, Crohn's disease, the intestinal microbiome, and bacterial proteins will be explored in samples from pairs of twins with and without the disease.

Ellen Li, M.D., Ph.D., Washington University School of Medicine, Saint Louis
Digestive tract: Crohn's Disease
$980,000
This study will analyze the intestinal microbiome and disease subjects' genetic factors to uncover relationships with Crohn's disease, an inflammatory bowel disease.

Huiying Li, Ph.D., University of California, Los Angeles
Skin: Acne
$990,000
The goal of this study is to examine the association between the skin microbiome and acne.

Zhiheng Pei, M.D., Ph.D., New York University School of Medicine
Mouth and digestive tract: Esophageal Adenocarcinoma
$1 million
This team will sample the oral cavity, esophagus, and stomach to study the relationship of the microbiome from these body sites and esophageal cancer.

Jacques Ravel, Ph.D., University of Maryland School of Me
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Contact: Geoffrey Spencer
spencerg@mail.nih.gov
301-402-0911
NIH/National Human Genome Research Institute
Source:Eurekalert

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