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NIH awards researcher $1.5 million 'new innovator' grant for fruit-fly studies of prion proteins
Date:9/18/2007

work as well. Next, theyll check any promising leads with experiments in mammalian cell cultures. Then, in experiments with both transgenic and normal mice in collaboration with Claudio Soto, also a UTMB professor and director of the university's George and Cynthia Mitchell Center for Neurodegenerative Diseases, theyll test whether they can extend such protection to mammals, both with genetic engineering and compounds that induce the production of chaperones.

By doing the groundwork in flies, we think we can find many new mechanisms of prion neurotoxicity, Fernandez-Funez said. The idea is that were going to keep looking for new ways of attacking the disease through all these new genes and proteins and pathways.


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Contact: Jim Kelly
jpkelly@utmb.edu
409-772-8791
University of Texas Medical Branch at Galveston
Source:Eurekalert

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