Navigation Links
NIH awards group $4.5 million for smart artificial pancreas technology
Date:10/26/2011

Santa Barbara, Calif. -- The National Institutes for Health (NIH) have awarded $4.5 million to a group of international diabetes researchers to engineer an artificial pancreas system that will monitor and adapt to the body's complex real-time changes in behavior and physiology. This collaboration between physicians and engineers aims to merge three key aspects of type 1 diabetes management human behavior, physiology, and medical technology and ultimately to transition their artificial pancreas technology into clinical practice.

"This is a groundbreaking project that assembles the world's leaders in artificial pancreas technology to not only expand in-clinic methods for control of blood sugar, but to pioneer the development of outpatient solutions that can bring improved quality of life to patients in their natural environment," said Professor Frank Doyle of UC Santa Barbara, Principal Investigator for this study. "It is a unique team with interdisciplinary strengths that range from control engineering to medical practice to behavioral science."

Setting their study apart is the focus on developing a more sophisticated program, or algorithm, which acts as the "brain" of the artificial pancreas. Called a closed-loop control (CLC) system, this algorithm is informed by the numerous physiological changes such as hormones, meals, stress, exercise and sleep and mimics the insulin creation function of a healthy pancreas. A CLC system that treats type 1 diabetes must be responsive to all daily challenges in life, and able to accurately predict blood glucose levels in advance.

"This is medically-inspired engineering, or engineering-inspired medicine," commented Doyle, a Chemical Engineering professor at UCSB who holds the Mellichamp Chair in Process Control. "One of the great advantages we have is that we are collaborating to mutually understand what is needed in both the research and clinical environments to make the artificial pancreas technology a reality."

UCSB is playing the lead role in organizing this international consortium of prominent diabetes researchers, an assembly of world leaders in the fields of computer modeling, control systems, simulation and clinical research. The artificial pancreas research group includes Professor Doyle, Howard Zisser of the Sansum Diabetes Research Institute, Boris Kovatchev of University of Virginia, Ananda Basu of the Mayo Clinic, and Claudio Cobelli of University of Padova, Italy.

In the United States, as many as 3 million people are living with type 1 diabetes, with more than 30,000 youth and adults diagnosed every year. Type 1 diabetes is an autoimmune disease wherein the body's immune system attacks and destroys the insulin-producing cells of the pancreas. For someone with type 1 diabetes, regulating their blood sugar level currently involves a daily regimen of multiple insulin injections or an insulin pump, in addition to blood sugar testing 8 10 times a day.

"Our final goal of an ambulatory artificial pancreas has the potential to make a tremendous impact on the health and lives of people with type 1 diabetes," said Howard Zisser, co-Principal Investigator and Director of Clinical Research at Sansum Diabetes Research Institute.

In recent years, Doyle and Zisser have collaborated to launch the Artificial Pancreas Program at SDRI and UCSB, and have been testing their system in inpatient clinical trials at SDRI. The development of CLC technology has made significant strides over the last five years, but the research consortium understands the challenges faced in gaining FDA approval for an artificial pancreas system.

"The typical research-to-clinical process can be slow because the academic research must be complete and approved before clinical trials can begin," explained Zisser. "Our study will be an example of translational medical research, or research conducted in the lab and safely in a clinical setting in a complementary way, continuously informing each process of what is successful or not. That is the strength of our collaboration."

Their ambulatory artificial pancreas project is supported by the National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases and administered by the Institute for Collaborative Biotechnologies at UCSB.


'/>"/>
Contact: Melissa Van De Werfhorst
melissa@engineering.ucsb.edu
805-893-4301
University of California - Santa Barbara
Source:Eurekalert  

Related biology news :

1. IOF Young Investigator Awards recognize research excellence at Dubai meeting
2. National Science Foundation makes first awards in Sustainability Research Coordination Program
3. MARC Travel awards announced for the ABRCMS meeting
4. Regenerating eyes using cells from hair: Stem Cells awards research into stem cell deficiency
5. Disney Worldwide Conservation Fund awards grant to R.J. Dunlap Marine Conservation Program
6. 11 women scientists announced as winners of Elsevier Foundation OWSD awards
7. White House announces that 2 UCSB faculty members will receive US presidential science awards
8. NIH awards $5.5 million grant to Weill Cornell for research into preventing spina bifida
9. Elsevier congratulates editors of Stem Cells: Scientific Facts and Fiction upon receipt of awards
10. NHTSA Awards Takata-TruTouch $2.25M to Advance Worlds First Touch-based In-Vehicle Alcohol Detection Device
11. GCEP awards $3.5 million for energy research
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
NIH awards group $4.5 million for smart artificial pancreas technology
(Date:3/29/2016)... March 29, 2016 LegacyXChange, Inc. ... "LEGX" and SelectaDNA/CSI Protect are pleased to announce our ... in a variety of writing instruments, ensuring athletes signatures ... created collectibles from athletes on LegacyXChange will be assured ... the DNA. Bill Bollander , CEO ...
(Date:3/21/2016)... , March 22, 2016 ... with passcodes for superior security   ... leading provider of secure digital communications services, today announced ... technology and offer enterprise customers, particularly those in the ... recognition and voice authentication within a mobile app, alongside, ...
(Date:3/15/2016)... March 15, 2016 Yissum Research Development ... technology-transfer company of the Hebrew University, announced today the ... sensing technology of various human biological indicators. Neteera Technologies ... million from private investors. ... the detection of electromagnetic emissions from sweat ducts, enables ...
Breaking Biology News(10 mins):
(Date:5/19/2016)... 2016 Regen BioPharma, ... RGBPP) announced today initiation of a preclinical development ... based cancer immunotherapeutic product leveraging its NR2F6 immunological ... a generation of cord blood derived killer cells ...  The product in development will be a "universal ...
(Date:5/18/2016)... ON (PRWEB) , ... May 18, 2016 , ... STACS ... DNA laboratories to easily track and report sexual assault kit processing to help them ... of attention as pressure escalates for kits to be processed and victims informed of ...
(Date:5/17/2016)... ... May 17, 2016 , ... ... waste reduction applications, announced today it will be showcasing ManureMagicâ„¢ at booth V1061 ... was featured in the Wall Street Journal last year and more recently made ...
(Date:5/17/2016)... Raleigh, NC (PRWEB) , ... May 17, 2016 , ... ... link between kidney and bladder cancer and mesothelioma in families. Surviving Mesothelioma has just ... , Although people with a family member with bladder or kidney cancer seem ...
Breaking Biology Technology: