Navigation Links
NIH awards UC $9 million grant to improve patient point-of-care technologies
Date:9/28/2007

A leading cause of disability in the United States is a neurological event such as stroke, head injury or drug abuse. Regardless of the cause, the brain is often quickly and irreversibly damaged. UC researchers, funded by a $9 million grant from the National Institutes of Health, will study point-of-care technologies to assist the diagnosis and treatment of patients with neurologic emergencies. The result is the "Point-of-Care Center for Emerging Neuro Technologies. This five-year award is renewable for five years.

It is estimated that one million brain cells die every minute during an ischemic stroke, says Fred Beyette, associate professor of electrical and computer engineering and principal investigator (PI) for the project. Its said that time is brain during a neurologic emergency. Point-of-care information is critical for preventing patient brain damage, dysfunction and death. Thus, there is a critical need for developing improved and rapid diagnostic information for the patient experiencing neurologic emergencies.

The UC center is dedicated to the development of technologies that will dramatically improve the care and health of the neurologic patient by providing fast and reliable information about the biological events occurring in this patient population, says Joseph Clark, professor of neurology in UCs College of Medicine and co-principal investigator (Co-PI) of the overall grant.

From Invention to Intervention

The focus of the Point-of-Care Center will be to nurture the development of technologies to improve the diagnosis of and response to neurodiseases and neurodisorders using point-of-care devices, whether at the bedside or in the operating room wherever diagnosis or treatment is needed, says Beyette. The NIH grant is intended to stimulate business in the community as well. The center will be structured to take ideas from conception to development of a prototype ready for clinical testing. Some of the factors that these new technologies will address include fast results in a package that is size-appropriate for the location.

For example, consider a patient with a persistent headache, lasting 18 to 20 hours. The patient has tried over-the-counter medications to no avail and is now experiencing nausea and visual impairment. Is it sinusitis" Migraine" Or perhaps a hemorrhagic stroke" Current technology takes hours to indicate the source of the problem. The improved point-of-care technologies could take a matter of one or two minutes. If the source is a migraine, then the patient would be referred to a general practitioner. If its meningitis, then a spinal tap is called for. However, if its an acute rupture of an artery in the brain, a CT scan is usually performed but is not effective after 12 hours following the event. A spinal tap would be called for but the information is often unreliable.

When a patient comes to an emergency room with a headache, blood and urine samples are routinely drawn. Spinal fluid tests are rarely used because of the minimal return on chemical information, says Clark. Current protocol would dictate sending the sample out for a biochemical assay, taking three to four hours. If the problem is a subarachnoid hemorrhage, its going to rupture again. But in doing the spinal tap, more blood might be introduced by the tap itself, making diagnosis difficult.

To address this, an instrument in development now is the size of a shoebox, into which the spinal fluid is introduced. Within three minutes, the instrument can distinguish hemoglobin and bilirubin (which indicates the breakdown of hemoglobin) from blood cells that might be present because of the procedure itself.

Beyette and Clark say that the center will be ramping up activities over the coming weeks and will soon be issuing a national call for proposals.

Winning this award speaks very highly of the quality of our team and the outstanding level of innovation that we are bringing to the diagnosis and treatment of neurologic-based diseases and disorders, says Beyette.


'/>"/>

Contact: Wendy Beckman
wendy.beckman@uc.edu
513-556-1826
University of Cincinnati
Source:Eurekalert

Related biology news :

1. A comprehensive response to HIV could prevent 10 million AIDS deaths in Africa by 2020
2. UCLA launches $20 million stem cell institute to investigate HIV, cancer and neurological disorders
3. Six million Africans face famine because of locusts, drought
4. Retrovirus struck ancestors of chimpanzees and gorillas millions of years ago, but did not affect ancestral humans
5. Evidence of 600-million-year old fungi-algae symbiosis discovered in marine fossils
6. $5.1 billion would save 6 million children
7. Health costs soar as 60 million Americans classed as obese
8. Malaria killing a million a year
9. $6.5 Million Grant for Microarray Center at Yale School of Medicine
10. TGen awarded $7.1 million to accelerate brain disease research
11. MSU researchers receive $4 million grant to uncover gene functions
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/16/2016)... May 16, 2016   EyeLock LLC , a ... the opening of an IoT Center of Excellence in ... expand the development of embedded iris biometric applications. ... of convenience and security with unmatched biometric accuracy, making ... aside from DNA. EyeLock,s platform uses video technology to ...
(Date:4/28/2016)... -- First quarter 2016:   , Revenues ... first quarter of 2015 The gross margin was 49% ... and the operating margin was 40% (-13) Earnings per ... from operations was SEK 249.9 M (21.2) , Outlook ... 7,000-8,500 M. The operating margin for 2016 is estimated ...
(Date:4/15/2016)... DUBLIN , April 15, 2016 ... of the,  "Global Gait Biometrics Market 2016-2020,"  report ... http://photos.prnewswire.com/prnh/20160330/349511LOGO ) , ,The global gait ... CAGR of 13.98% during the period 2016-2020. ... movement angles, which can be used to compute ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... ... June 27, 2016 , ... Cancer experts from Austria, Hungary, ... be a new and helpful biomarker for malignant pleural mesothelioma. Surviving Mesothelioma has ... it now. , Biomarkers are components in the blood, tissue or body ...
(Date:6/27/2016)... ... June 27, 2016 , ... ... Amgen, will join the faculty of the University of North Carolina Kenan-Flagler ... of strategy and entrepreneurship at UNC Kenan-Flagler, with a focus on the school’s ...
(Date:6/24/2016)... TOKYO , June 24, 2016  Regular discussions on ... to take place between the two entities said Poloz. ... in Ottawa , he pointed to the ... and the federal government. ... Poloz said, "Both institutions have common economic goals, why not ...
(Date:6/24/2016)... ... June 24, 2016 , ... Researchers at the Universita Politecnica delle Marche ... with peritoneal or pleural mesothelioma. Their findings are the subject of a new article ... Diagnostic biomarkers are signposts in the blood, lung fluid or tissue of mesothelioma patients ...
Breaking Biology Technology: