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NIH awards Rutgers $47.5 million to advance groundbreaking research on protein structures
Date:9/30/2010

other academic institutions. Over the past 10 years of the PSI program, the group has determined nearly a thousand 3D protein structures using techniques that investigators have developed.

"The PSI program, a follow-on to the human genome sequencing project, has contributed extensive new information about the structures and functions of tens of thousands of proteins," Montelione said. He noted that NESG has made essential contributions by determining 3D structures of proteins associated with cancer, developmental biology, viruses and their complexes with human host proteins, and bacterial pathogens, such as those that infect immuno-compromised AIDS patients.

"These structures provide new insights into how these protein molecules work and point to new targets for therapeutic drug development," he said.

The Structural Biology Knowledgebase (SBKB) collects and disseminates data generated by investigators in the PSI network, including protein structures, theoretical models, protocols and technologies. The SBKB also provides central access to genetic, structural and functional annotations from more than 150 publicly available biological databases, and to the protein structures in the Protein Data Bank (PDB), an online resource of experimentally determined biological structures. Both the SBKB and the PDB are maintained by the Research Collaboratory for Structural Biology, directed by Helen M. Berman, Board of Governors Professor of Chemistry and Chemical Biology at Rutgers.

"The SBKB has been designed to give facile access to information about every step in the protein structure determination pipeline as well as the roles of these proteins in living systems and disease," Berman said. "Over the coming years, we will continue to expand the scope of our services so as to better enable biological research."

Montelione and Berman are also resident members of the Center for Advanced Biotechnology and Medicine (CABM), a research and t
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Contact: Carl Blesch
cblesch@ur.rutgers.edu
732-932-7084 x616
Rutgers University
Source:Eurekalert

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