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NIH awards Argonne $800,000 to develop tool to measure distances within proteins
Date:9/3/2008

teins' surface and follow the process of protein or RNA folding. It would also give pharmaceutical companies the chance to observe how their drugs interact with proteins, potentially saving time and expenses by providing them with unique insight into the mechanism of action of the drugs.

The MADMAX program will take advantage of the Argonne's Advanced Photon Source, the brightest source of x-rays in the Western Hemisphere, and open to 3,500 users per year.

The MADMAX program is set to run for four years and will determine if the method would be suitable for the study of proteins on a routine basis. The team will begin by developing software and data collection protocols and then move on to study well-known compounds such as hemoglobin and HIV protease to check the accuracy of the method.

The EUREKA program designed to encourage 'Exceptional Unconventional Research Enabling Knowledge Acceleration' is in its first year and is funded by the NIH to support exceptionally innovative research which has potential to have a high impact in the scientific community.

"EUREKA is an experiment in how to attract, identify, and support particularly creative approaches that, if successful, could move science forward dramatically," said Jeremy M. Berg, Ph.D., director of the National Institute of General Medical Sciences, which led the development of the EUREKA program.

"EUREKA projects promise remarkable outcomes that could revolutionize science," said NIH Director Elias A. Zerhouni, M.D. "The program reflects NIH's commitment to supporting potentially transformative research, even if it carries a greater than usual degree of scientific risk."


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Contact: Angela Hardin
ahardin@anl.gov
630-252-5501
DOE/Argonne National Laboratory
Source:Eurekalert

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