Navigation Links
NIH awards $8.5 million for research on pharmaceuticals for children
Date:11/17/2009

Studying drugs in pediatric populations is challenging because drugs often affect children differently than they do adults. The scarcity of pediatric studies limits the ability of doctors and scientists to predict drug dosing, safety and efficacy in children. To address this gap, the National Institutes of Health announced today 18 grants to help determine outcome measures and increase the likelihood of success of future trials of treatments for children.

The grants were awarded to 17 Clinical and Translational Science Award (CTSA) institutions to support 18 studies of pharmaceutical treatments for children. The CTSA consortium is a national network of 46 medical research institutions working together to improve the way biomedical research is conducted across the country. The $8.5 million in funding will support studies which focus on three areas critical to health: pediatric cardiology, neonatology and pediatric neurology.

The awards will be administered by the National Center for Research Resources (NCRR) while the funding was provided by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD). The NCRR and NICHD are part of the NIH.

"These awards exemplify what the CTSA program supports: innovative, transformative and collaborative research," said Barbara Alving, M.D., director of NCRR. "These CTSA institutions are uniquely positioned to deliver outcomes in these studies that may translate into better treatments for children in the future. "

The funding is part of NIH's continuing efforts in studying drugs for use in pediatric populations. The Best Pharmaceuticals for Children Act of 2002 established a process to study on-patent and off-patent drugs for children and to improve pediatric therapeutics through collaboration on scientific investigation, clinical study design, weight of evidence, and ethical and labeling issues.

"People of different ages require research outcome measures that are tailored to their size and condition," said Steven Hirschfeld, M.D., Ph.D., NICHD associate director for clinical research. "These studies will fill a critical gap by providing the precision needed to understand outcomes for younger patients who may respond differently than adults, and thereby enhance the quality of pediatric research."

As an example, premature infants often suffer from a lung condition called bronchopulmonary dysplasia (BPD), which requires the use of oxygen and other supportive measures, and places them at high risk for developing chronic respiratory obstruction later in life. However, researchers have found that the success of therapies used to treat BPD in newborns did not necessarily correlate with success in staving off the chronic conditions, suggesting the currently used outcome measures are not reliable. To address this deficiency, two separate projects have been funded and will be conducted by researchers at the University of North Carolina at Chapel Hill and at Tufts University. The goals of the of these projects are to develop new tools to define the extent of functional impairment due to BPD in neonates and to establish a registry to track and quantify the onset and extent of chronic lung problems in these at-risk infants as they grow older, respectively.

In another example, the tools such as blood pressure cuffs that doctors use to diagnose and treat hypertension were developed for adults and have never been validated in children. As a result, researchers have had a hard time detailing the effectiveness of treatments for high blood pressure in children. To address this problem, researchers at Case Western Reserve University received funding to adapt the blood pressure cuffs to children. To better understand blood pressure patterns in children, a consortium of five CTSAs led by investigators at the Albert Einstein College of Medicine will enroll children between the ages of 10 and18 years into a six-month study of the effect of home-based diet and lifestyle modification on blood pressure.


'/>"/>

Contact: Bobbi Williams
williamsbj@mail.nih.gov
301-443-9919
NIH/National Center for Research Resources
Source:Eurekalert

Related biology news :

1. The American Society of Plant Biologists announces 2007 awards
2. Singapore National Science and Technology Awards
3. Homeland Security awards 2 grants to Rutgers for nuclear threat detection
4. NIH awards nearly $23M to University of Chicago for translational research
5. NIH awards researcher $1.5 million new innovator grant for fruit-fly studies of prion proteins
6. PETA awards $120,000 to Duluth Foundation for advancing non-animal tests
7. NIH awards UC $9 million grant to improve patient point-of-care technologies
8. NIST announces 56 new awards for innovative technology research and development
9. USP awards verified mark to Dr. Reddys Laboratories, Ltd. ingredients
10. Simons Foundation awards Emory scientists $3M for autism gene research
11. NIH grants $33 M in institutional development awards to 3 states
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/8/2016)... LOS ANGELES and MANCHESTER, United Kingdom ... ("BBI"), a developer of innovative sensor-based diagnostic products, today ... was financed by new and existing investors.  Proceeds from the ... SEM Scanner , a hand-held device for detecting early-stage ... and Ireland after receiving CE Mark ...
(Date:1/7/2016)... 7, 2016 Various factors have contributed ... such as biologics and biosimilars. Some of these ... expenditure, growing demand for cost-effective alternatives, growing burden ... are similar versions of their corresponding patented biologic ... quality, safety, and efficacy. The global biosimilars market ...
(Date:1/6/2016)... 2016 Based on its recent analysis ... recognizes MorphoTrak, LLC, a U.S. subsidiary of Morpho ... Sullivan Company of the Year Award. The success ... Wave™ , has consolidated the company,s position as ... Morpho Wave is a highly accurate and ...
Breaking Biology News(10 mins):
(Date:2/4/2016)... ... February 04, 2016 , ... Shimadzu Scientific Instruments ... host live demos and poster sessions, and present on the analysis of mycotoxins ... place March 6 to 10 at the Georgia World Congress Center in Atlanta, ...
(Date:2/4/2016)... and MENLO PARK, Calif. , ... DMPI) ("DelMar" and the "Company"), a biopharmaceutical company focused on ... that it will present at the 18 th ... 8, 2016 at 10:00 a.m. EST in New ... DelMar,s president and CEO, will provide an update on the ...
(Date:2/4/2016)... 2016 Sinovac Biotech Ltd. ("Sinovac" or the ... biopharmaceutical products in China , today ... directors received on February 4, 2016 a preliminary non-binding ... comprised of PKU V-Ming ( Shanghai ) ... Qianhai Development ( Shenzhen ) Fund Management ...
(Date:2/3/2016)...   ViaCyte, Inc ., a leading, privately-held ... cell-derived islet replacement therapy for the treatment of ... that ViaCyte and Janssen Biotech, Inc., one of ... have agreed to consolidate the assets of the ... ViaCyte with an exclusive license to all BetaLogics ...
Breaking Biology Technology: