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NIH awards $7.5 million to study MRI as a tool to evaluate children with muscular dystrophy
Date:5/7/2010

rders and Stroke and will include researchers at Oregon Health and Science University, Children's Hospital of Philadelphia and the University of Pennsylvania. Researchers at the four sites will conduct MRI measurements of muscle in 100 boys with Duchenne, ages 5 through 14, over a five-year period.

"We are confident that by the end of the study we will be able to provide clear guidelines for how MRIs should be performed in Duchenne muscular dystrophy and that MRIs will be a valuable tool in clinical trials and drug tests targeting potential Duchenne treatments," Vandenborne said.

Preliminary studies, funded by Parent Project Muscular Dystrophy and the Muscular Dystrophy Association, involved about 30 boys and demonstrated that MRI had many advantages over traditional muscle biopsies, Vandenborne said. Biopsies are invasive and do not give researchers a complete view of all the muscle tissue.

"NIH is excited to award this important research grant to Dr. Vandenborne," said Glen Nuckolls, Ph.D., program director of the Muscle Disorders and Therapies Program at the National Institute of Arthritis and Musculoskeletal and Skin Diseases. "It is the type of thorough observational study that will collect data needed to design better clinical trials for DMD. Magnetic resonance imaging and spectroscopy are powerful tools to look inside the muscles of patients and measure chemicals in the muscles, and this study has the potential to show that these would be very valuable tools in determining whether an experimental therapy is working to improve the muscles of boys with DMD."


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Contact: Jill Pease
jpease@phhp.ufl.edu
352-273-5816
University of Florida
Source:Eurekalert

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