Navigation Links
NIH awards $7.5 million to study MRI as a tool to evaluate children with muscular dystrophy
Date:5/7/2010

Duchenne muscular dystrophy research at the University of Florida got a major boost with the award of $7.5 million in National Institutes of Health funding to study the use of magnetic resonance imaging in determining the natural progression of the disease.

UF scientists will assess whether MRI technology can be used as a precise, noninvasive measure of muscle tissue in children with Duchenne muscular dystrophy. Understanding how the disease affects muscle tissue could help facilitate the testing of new therapies in clinical trials, researchers say.

Duchenne muscular dystrophy affects about one of every 3,500 to 5,000 boys born each year in the United States, according to the Centers for Disease Control and Prevention. The disease causes the muscles that control movement to progressively weaken and lose the ability to regenerate after an injury, eventually replacing critical muscle tissue with fat and collagen. By age 12, many patients need a wheelchair. As the disease advances, the heart and respiratory system are affected and patients often die of cardiorespiratory failure in their 20s.

"The lack of a reliable assessment tool for measuring muscle function in patients with Duchenne inhibits the transfer of new therapies from the lab to clinical trials," said the study's lead investigator KristaVandenborne, Ph.D., an associate dean for research and planning at the UF College of Public Health and Health Professions and chair of the department of physical therapy. "MRI allows you to look at the structure of a muscle tissue in a very objective way with a large amount of detail. Our goal is to develop MRI as a tool to see the progression of the disease, but more importantly, to determine if a new treatment is effective or not, giving researchers rapid feedback about potential new drugs."

The study is funded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases and the National Institute of Neurological Disorders and Stroke and will include researchers at Oregon Health and Science University, Children's Hospital of Philadelphia and the University of Pennsylvania. Researchers at the four sites will conduct MRI measurements of muscle in 100 boys with Duchenne, ages 5 through 14, over a five-year period.

"We are confident that by the end of the study we will be able to provide clear guidelines for how MRIs should be performed in Duchenne muscular dystrophy and that MRIs will be a valuable tool in clinical trials and drug tests targeting potential Duchenne treatments," Vandenborne said.

Preliminary studies, funded by Parent Project Muscular Dystrophy and the Muscular Dystrophy Association, involved about 30 boys and demonstrated that MRI had many advantages over traditional muscle biopsies, Vandenborne said. Biopsies are invasive and do not give researchers a complete view of all the muscle tissue.

"NIH is excited to award this important research grant to Dr. Vandenborne," said Glen Nuckolls, Ph.D., program director of the Muscle Disorders and Therapies Program at the National Institute of Arthritis and Musculoskeletal and Skin Diseases. "It is the type of thorough observational study that will collect data needed to design better clinical trials for DMD. Magnetic resonance imaging and spectroscopy are powerful tools to look inside the muscles of patients and measure chemicals in the muscles, and this study has the potential to show that these would be very valuable tools in determining whether an experimental therapy is working to improve the muscles of boys with DMD."


'/>"/>

Contact: Jill Pease
jpease@phhp.ufl.edu
352-273-5816
University of Florida
Source:Eurekalert

Related biology news :

1. ASNTR meeting presents Sanberg Awards to Prof. Lin & Prof. Dunnett
2. Ames Laboratory scientists win national technology transfer awards
3. Sandia wins 2 national technology transfer awards for work with Cray, Stirling Energy Systems
4. EPA awards more than $1 million to college teams for environmental innovation
5. Autism Speaks awards 16 new research grants funding more than $5 million over next 3 years
6. Washington State Life Sciences Discovery Fund awards health research program grants
7. Ohio Third Frontier awards million-dollar grant to YSI-University of Cincinnati team
8. 2010 Human Frontier Science Program awards announced
9. NYU School of Medicine presents biomedical researchers Dart/NYU Biotechnology Achievement Awards
10. SEBM Distinguished Scientist Awards for 2010
11. AADR awards 2010 Neal W. Chilton Fellowship in Clinical Research to Dolphus Dawson, III
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2016)... GOTHENBURG, Sweden , April 28, 2016 ... 1,491.2 M (139.9), up 966% compared with the first quarter of ... Operating profit totaled SEK 589.1 M (loss: 18.8) and the operating ... SEK 7.12 (loss: 0.32) Cash flow from operations was ... , The 2016 revenue guidance is unchanged, SEK 7,000-8,500 M. ...
(Date:4/19/2016)... 2016 The new GEZE SecuLogic ... web-based "all-in-one" system solution for all door components. It ... the door interface with integration authorization management system, and ... The minimal dimensions of the access control and the ... installations offer considerable freedom of design with regard to ...
(Date:4/14/2016)... April 14, 2016 BioCatch ... Detection, today announced the appointment of Eyal Goldwerger ... role. Goldwerger,s leadership appointment comes at a ... of the deployment of its platform at several of ... technology, which discerns unique cognitive and physiological factors, is ...
Breaking Biology News(10 mins):
(Date:4/27/2016)... SPRING, Md. and RESEARCH TRIANGLE ... Therapeutics Corporation (NASDAQ: UTHR ) announced today ... Executive Officer, of United Therapeutics will provide an overview ... Bank 41 st Annual Health Care Conference. ... 5, 2016, at 10:00 a.m. Eastern Time, and can ...
(Date:4/27/2016)... ... 27, 2016 , ... PathSensors, Inc., a leading environmental testing ... will assist PathSensors in expanding the use of the company’s CANARY® technology in ... platform for the detection of harmful pathogens, including a number of bacteria, viruses, ...
(Date:4/27/2016)... ... ... Global Stem Cells Group and the University of Santiago Biotechnology Lab have ... for potential stem cell protocol management for 2016 – 2020. , In 2015, ... establish a working agenda and foster initiatives to promote stem cell research and development ...
(Date:4/26/2016)... ... April 27, 2016 , ... ... Roca Rothgerber Christie LLP as an associate in the firm’s Intellectual Property practice ... electrical, mechanical and electromechanical patent applications. He has an electrical engineering and computer ...
Breaking Biology Technology: