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NIH awards $17 million Program of Excellence Award in glycosciences to Brigham and Women's Hospital
Date:7/7/2011

gents to program discrete sugar modifications on the surface of live cells to achieve predetermined biologic effects. In a comprehensive multidisciplinary and interdisciplinary approach with collaborators Dr. Karen Hoffmeister, also of BWH, Dr. Joseph Lau, of Roswell Park Cancer Institute, and Dr. Vernon Rheinhold, of the University of New Hampshire, Dr. Sackstein's PEG project will specifically define how cell surface sugar modifications regulate blood cell production under both normal and pathologic conditions. The overarching goal of the program is to characterize the structure and function of certain sugars displayed on blood-forming cells, and thereby provide insights on how display of such sugars can be enforced to achieve therapeutic effects.

The PEG award was conceived and established by the NHLBI when current BWH President Elizabeth G. Nabel, MD, directed the institute. "Research in glycobiology has potential to advance patient care by improving blood cell development and treatments for blood diseases," said Dr. Nabel. "It is gratifying to see this translational work carried out at BWH."

Beyond funding critical research objectives, the Award also provides support for training investigators in glycobiology as well as support for key core resources for characterization and analysis of sugar modifications. With the express intent to provide the requisite investigative skills and resources to define how modulation of sugar modifications can advance needed breakthroughs in diagnosis, treatment and prevention of disease, the Award will thus spearhead the development of glycobiology at BWH and, more generally, at other research institutions of the northeast US.


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Contact: Holly Brown-Ayers
hbrown-ayers@partners.org
Brigham and Women's Hospital
Source:Eurekalert  

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