"The investigators will collaborate to develop diagnostic criteria for identifying the chronic features of the entire scope of brain trauma ranging from mild TBI to full-blown CTE, and then work to extend these criteria to living humans using some of the most advanced neuroimaging tools available," said Walter Koroshetz, M.D., deputy director of NINDS.
"Although the two cooperative agreements focus on different aspects of TBI, their combined results promise to answer critical questions about the chronic effects of single versus repetitive injuries on the brain, how repetitive TBI might lead to CTE, how commonly these changes occur in an adult population, and how CTE relates to neurodegenerative disorders like Alzheimer's disease," Dr. Landis said.
The pilot studies will focus on improving the diagnosis of concussion and identifying potential biomarkers that can be used to track a person's recovery. The six pilot grants are:
The brain contains numerous chemicals such as gamma-amino butyric acid (GABA), which is important for many brain functions, including cognition and movement, and may be altered by traumatic brain injury. Magnetic resonance (MR) spectroscopy is a scanning technique that can measure a variety of brain chemicals, including GABA. The goal of Dr. Ojemann's project is to use MR spectroscopy to monitor GABA levels in adolescents who have sports-related concussions and compare those levels to uninjured controls. The researchers also will conduct preliminary comparisons of GABA levels with existing cognitive measures such as memory tests and structural brain imaging. Diagnostic tools that can reliably detect when the brain is injured and when it has recovered following a concussion are essential for determining when it is saf
|Contact: Barbara McMakin|
NIH/National Institute of Neurological Disorders and Stroke