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NIH and NFL tackle concussion research
Date:12/16/2013

University School of Medicine and U.S. Department of Veterans Affairs

At present, the diagnosis of CTE is made by examining the brain after death; however, the range of specific features that identify this disorder has not been established. One goal of Dr. McKee's project is to define a clear set of criteria for the various stages of CTE and to distinguish it from Alzheimer's, amyotrophic lateral sclerosis, and other neurodegenerative disorders in post-mortem brain tissue. Once these characteristics have been defined in brain tissue, the imaging teams at Washington University in St. Louis and Massachusetts General Hospital in Boston will correlate them with brain scans to identify features that might eventually be used to diagnose CTE in individuals during their lifetimes.

  • Neuropathology of CTE and Delayed Effects of TBI: Toward In Vivo Diagnostics
    Principal Investigator: Wayne Gordon, Ph.D., Mount Sinai Hospital, New York City

    The goal of Dr. Gordon's project is to identify and describe the chronic effects of mild, moderate and severe TBIs and compare these with the features of CTE. Dr. Gordon and his colleagues at the University of Washington in Seattle will comprehensively evaluate brain tissue obtained from an ongoing study of thousands of people, the Adult Changes in Thought (ACT) study, funded by the National Institute of Aging. They also will examine brain tissue from donors who suffered severe TBI and were cared for in the TBI Model Systems program funded by the Department of Education's National Institute on Disability and Rehabilitation Research. In Dr. Gordon's project, neuroimaging teams at Massachusetts General Hospital, Oregon Health Sciences University in Portland, and the University of Washington will use a variety of sophisticated brain scanning techniques in patients with a range of head injuries, as well as on post-mortem tissue, to identify potential markers that may eventually be used to diagnose the degen
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  • Contact: Barbara McMakin
    nindspressteam@ninds.nih.gov
    301-496-5751
    NIH/National Institute of Neurological Disorders and Stroke
    Source:Eurekalert

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