Navigation Links
NIH TRND program announces next round of drug development projects
Date:11/15/2011

This stage of drug development is called the "Valley of Death."

TRND began five pilot projects to establish the proof-of-principle and operating protocols for the program soon after it was established in 2009. Those projects include potential treatments for the neurodegenerative disease Niemann-Pick type C, the neuromuscular disorder hereditary inclusion body myopathy, the blood disorder sickle cell disease, a rare blood cancer known as chronic lymphocytic leukemia, and the parasitic worm diseases schistosomiasis and hookworm. The chronic lymphocytic leukemia and the sickle cell disease projects have recently received investigational new drug approval from the FDA and are in clinical trials.

Earlier this year, TRND approved its first four drug development projects from its initial solicitation. They focus on potential new treatments for Duchenne muscular dystrophy, a degenerative muscle disorder; fragile X syndrome, the most common inherited form of cognitive and developmental disabilities; cryptococcal meningitis, an infectious fungal disease; and core binding factor leukemia, a rare blood and bone marrow cancer.

"TRND selects projects based on their potential to move forward into human trials and transform patient care in diseases for which there is little or no therapy," said Christopher P. Austin, M.D., scientific director of the NIH Center for Translational Therapeutics, which oversees TRND and is administered by the National Human Genome Research Institute (NHGRI). "While such projects are high-risk, the scientific opportunities and medical needs are compelling. After rigorous scientific review, the new projects were selected to maximize the chance of success and to teach us important generalizable lessons about rare and neglected disease drug development."

The latest TRND projects, approved by the advisory council of the National Institute of Neurological Disorders and Stroke (NINDS) on behalf of NIH, and the collaboratin
'/>"/>

Contact: Geoffrey Spencer
spencerg@mail.nih.gov
301-451-8325
NIH/National Human Genome Research Institute
Source:Eurekalert

Page: 1 2 3 4 5

Related biology news :

1. Researchers develop new self-training gene prediction program for fungi
2. Childrens gardening programs grow environmental stewards
3. Color My Pyramid nutrition education program battles obesity in DC schools
4. Yamanaka eliminates viral vector in stem cell reprogramming
5. Salk researchers successfully reprogram keratinocytes attached to a single hair
6. Evolved Machines Selected as a Prime Contractor for DARPA Program to Engineer an Artificial Olfaction System
7. International Council for Science launches major research program on natural disasters
8. ICSU launches new program to understand the human impact on Earths life-support systems
9. SAIC Awarded $37 Million Contract to Support U.S. Army Program Executive Office - Enterprise Information Systems
10. TECNALIA leads five projects within the VII Framework Program
11. NWO and Academy launch research program with China
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/6/2014)... from a team of Florida State University biologists could ... adapt to and survive environmental swings such as droughts ... issue of the journal The Plant Cell , ... and proteins) is organized in a cell and how ... turned on and others are turned off. , "If ...
(Date:11/6/2014)... November 6, 2014 - Insilico Medicine, Inc, a ... and age related diseases announced a research collaboration ... cancer, Champions Oncology, Inc (OTC: CSBR). , "There ... personalized medicine, but Champions Oncology,s TumorGraft technology is ... the chemotherapy regimen experimentally generating vast amounts of ...
(Date:11/5/2014)... show great diversity in their ability to identify scents ... differ in their perceptual evaluation of odors, with women ... , Sex differences in olfactory detection may play ... connected to one,s perception of smell, which is naturally ... superiority has been suggested to be cognitive or emotional, ...
Breaking Biology News(10 mins):Maize analysis yields whole new world of genetic science 2Insilico Medicine, Inc announces research collaboration with Champions Oncology, Inc 2The female nose always knows: Do women have more olfactory neurons? 2
... create autoimmune response , New research finds the human ... it to produce better antibodies in less time because ... attack the body's own tissues. The Rice University study ... for producing antibodies that are both effective against pathogens ...
... A Howard Hughes Medical Institute investigator from Albany, New ... Aires, Argentina have combined their expertise to identify two ... that causes Chagas disease. Their findings could help scientists ... whose cardiac complications kill up to 30 percent of ...
... Researchers at the Vaccine and Gene Therapy Institute (VGTI) ... diagnostic methods to better detect future monkeypox or smallpox ... 2003 monkeypox outbreak in the Midwest -- monkeypox is ... the 2003 outbreak was larger than the 72 cases ...
Cached Biology News:Immune system has evolved to prevent autoimmune disease 2Immune system has evolved to prevent autoimmune disease 3North & South American researchers find architectural abnormalities in T. cruzi ribosome 2North & South American researchers find architectural abnormalities in T. cruzi ribosome 3North & South American researchers find architectural abnormalities in T. cruzi ribosome 4Researchers develop new testing methods for potential monkeypox or smallpox outbreak 2Researchers develop new testing methods for potential monkeypox or smallpox outbreak 3
(Date:11/26/2014)... 2014 2014 Deep Research Report ... research report on the Global Palmitic Acid industry. ... Acid, basic information, including definition, classification, application, industry ... analysis, etc. , For international and China ... market in China and other countries or ...
(Date:11/26/2014)... 2014  Roka Bioscience, Inc. (NASDAQ: ROKA ), ... for the detection of foodborne pathogens, today announced that ... 26 th Annual Healthcare Conference on December 2, 2014 ... New York Palace in New York, NY ... the Company, its operations, strategies and prospects may be discussed. ...
(Date:11/24/2014)... , Nov. 24, 2014 VolitionRx Limited ... diagnostic tests for cancer and other conditions, today announced that ... at the Science for Business BioWin Day 2014, being held ... The data come from VolitionRx,s lung cancer pilot study, the ... the Centre Hospitalier Universitaire (CHU) de Liege in ...
(Date:11/24/2014)... Continental Clinical Solutions, LLC (Continental) focuses ... at its mid-Atlantic late-phase research facility, located in ... the idea of closing patient disparities in mind. ... advances," said Continental's CEO, Saleh Stevens . ... cell line of Henrietta Lacks, dubious ethical practices ...
Breaking Biology Technology:Palmitic Acid Industry Global 2014 Analysis & 2020 Forecasts on Market data, Statics, Development Now at ReportsnReports.com 2Palmitic Acid Industry Global 2014 Analysis & 2020 Forecasts on Market data, Statics, Development Now at ReportsnReports.com 3Roka Bioscience to Present at the Piper Jaffray Healthcare Conference 2VolitionRx to Present Positive Data from Pilot Lung Cancer Study at BioWin Day 2014 2VolitionRx to Present Positive Data from Pilot Lung Cancer Study at BioWin Day 2014 3VolitionRx to Present Positive Data from Pilot Lung Cancer Study at BioWin Day 2014 4VolitionRx to Present Positive Data from Pilot Lung Cancer Study at BioWin Day 2014 5VolitionRx to Present Positive Data from Pilot Lung Cancer Study at BioWin Day 2014 6At Continental Clinical Solutions, CEO Saleh Stevens Focuses on Diversity in Clinical Trial Recruitment at Maryland Site 2At Continental Clinical Solutions, CEO Saleh Stevens Focuses on Diversity in Clinical Trial Recruitment at Maryland Site 3
... incorporates naturally occurring soil micro-organism proteins to protect ... Dow AgroSciences LLC, a wholly owned subsidiary of ... ), today announced that it has received regulatory ... Biosafety (CTNBio), for its WideStrike(TM) Insect Protection ...
... 19 CryoLife, Inc. (NYSE: CRY ), ... announced today that it will participate in the Sidoti & ... at The Grand Hyatt Hotel on Wednesday, March 25, 2009.D. ... financial officer of CryoLife, Inc., will present a corporate overview ...
... Records, Billing and Inventory, and JCAHO ComplianceOAKLAND, ... leading provider of fully integrated medical imaging ... collect interventional radiology procedural information at the ... data capture for both general and vascular ...
Cached Biology Technology:Dow AgroSciences Receives Approval for New Technology to Control Cotton Pests in Brazil 2CryoLife to Present at Sidoti's 13th Annual New York Emerging Growth Institutional Forum 2LUMEDX Launches New Interventional Radiology Software 2
CQCS kit for first KR 4i , (first unit)....
... Wellpro 384, compatible ... automated liquid handling system ... quickly and accurately prepares ... dilutions. The Wellpro ...
...
...
Biology Products: