Navigation Links
NIEHS invests $21.25 million to find environmental causes of Parkinson's disease
Date:9/16/2008

ese functions in dopamine neurons. Identifying these mechanisms could lead to new therapeutic targets. In addition, the Emory team will be attempting to develop new biomarkers in the blood that will help identify people that may be at risk for developing Parkinson's disease.

  • Marie-Franoise Chesselet, M.D., Ph.D., University of California, Los Angeles

The researchers at UCLA have previously shown associations between high levels of exposure to specific environmental pesticides and Parkinson's disease and will build on this knowledge to determine the mechanisms of action that may be causing this association. They will use an integrated, multidisciplinary approach to identify additional agricultural pesticides that are disrupting similar molecular pathways, and determine whether these also increase the risk of Parkinson's. Their work is expected to shed light on the pathological processes involved in sporadic Parkinson's disease, the most frequent form of the disorder, and could have public health implications for precautions in the use of some pesticides.

  • Stuart Lipton, M.D., Ph.D., Burnham Institute for Medical Research, La Jolla, Calif.

Investigators at the Burnham Institute will explore how environmental toxicants may contribute to Parkinson's disease by producing free radical stress that mimics or enhances the effects of known genetic mutations. The focus will be on those proteins known to be related to Parkinson's disease, including parkin, DJ-1 and PINK1, with the goal of determining how chemical reactions that donate extra electrons lead to damaging modifications of these proteins. The clinical implications of these processes will be explored through biomarker development efforts and a screen to identify new lead compounds that can preserve protein function by reducing free radical stress.

"The UCLA and Emory CNS grants will extend the exciting lines of research previously supported by NIEHS thro
'/>"/>

Contact: Robin Mackar
rmackar@niehs.nih.gov
919-541-0073
NIH/National Institute of Environmental Health Sciences
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Duke-NIEHS team shows how DNA repairs may reshape the genome
2. The AGA Foundation invests in gastroenterologys future
3. Helios Education Foundation invests $6.5 million
4. NOAA invests $3 million for unmanned aircraft system testing
5. NIBIB invests in quantum research
6. Genes, Environment and Health Initiative invests in genetic studies, environmental monitoring
7. Cornell gets $10 million NSF grant to establish new sustainability institute
8. NYU, American Museum of Natural History receive $1.6 million NSF grant
9. Clear(R) Secures $44.4 Million in Venture Funding
10. UGA gets $2.5 million in grants to study plants to make biofuels
11. LSUHSCs Lazartigues awarded $1.2 million grant
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2014)... June 27, 2014  The American Academy of ... of Standards and Technology (NIST) and the Department ... research and forensic science expert members to the ... an element of the NIST,s Organization of Scientific ... the first appointments made to the new FSSB ...
(Date:7/10/2014)... , July 2, 2014  Unisys Corporation,s (NYSE: ... , Unisys Nederland N.V., today announced that it has been ... implement and manage a new Basic Provision Biometrics solution for ... Unisys won the contract with a solution based on ... software. The term of the contract is up to seven ...
(Date:7/10/2014)... , July 3, 2014 Research ... addition of the "Global Gesture Recognition & ... - Forecasts to 2020" report to their ... Global Gesture Recognition & Touch-Less Sensing Market ... around for a while, but the companies were ...
Breaking Biology News(10 mins):Ten Members of the American Academy of Forensic Sciences Appointed to Forensic Science Standards Board (FSSB) 2Ten Members of the American Academy of Forensic Sciences Appointed to Forensic Science Standards Board (FSSB) 3Unisys Delivers New Basic Provision Biometrics Solution to Dutch Custodial Institutions Service 2Unisys Delivers New Basic Provision Biometrics Solution to Dutch Custodial Institutions Service 3Global Gesture Recognition & Touch-Less Sensing (2D, 3D, Ultrasonic, IR, Capacitive) Market - Forecasts to 2020 2
... is "Molecule of the Year 2009". This was announced ... Society for Molecular and Cell Biology and Biotechnology Protocols ... Zsuzsanna Izsvk, Dr. Zoltn Ivics and Dr. Lajos Mts ... Berlin-Buch. According to the jury, it was selected out ...
... current controversy over vertebroplastya minimally invasive treatment performed ... vertebral compression fractures that fail to respond to ... your medical team to decide if you are ... experience of hundreds of thousands of other patients ...
... BOSTON (January 19, 2010, 12:00 noon EST) A study ... School of Graduate Biomedical Sciences at Tufts, and Tufts Medical ... cancer. The researchers propose a new model for breast cell ... which appears to be the cell of origin for luminal-like ...
Cached Biology News:'Sleeping Beauty' -- Molecule of the Year 2Society of Interventional Radiology supports treatment for spine fractures: Patient selection key 2Society of Interventional Radiology supports treatment for spine fractures: Patient selection key 3Society of Interventional Radiology supports treatment for spine fractures: Patient selection key 4Cell of origin identified for common type of breast cancer 2
(Date:7/10/2014)... 2014 Research and Markets ( http://www.researchandmarkets.com/research/s3bqj2/photonic ... "International Photonic Integrated Circuit (Monolithic Integration, Hybrid Integration, ... report to their offering. ... photonic integration traces its roots in the latter ... photonic integration went unexplored and unfulfilled for several ...
(Date:7/10/2014)... microscopic polymer light resonators that expand in the ... Photonics Laboratory have developed new optical sensors with ... sensors are ideal for detecting trace gas concentrations ... nature, and immunity to electromagnetic interference. , Although ... the MIT team conceived an extremely sensitive, compact ...
(Date:7/10/2014)... The lithium-ion batteries that power our laptops and electric ... a single charge with the help of a sponge-like ... to replace the graphite traditionally used in one of ... times the energy storage capacity of graphite. A paper ... was published today in Nature Communications . , ...
(Date:7/10/2014)... new alliance will see the two universities and NPL ... with business and industry and their complementary academic strengths., ... help to shape the scientific priorities of the UK. ... up to 300 high-calibre PhD students, will provide a ... NPL, the potential of the Laboratory will be grown ...
Breaking Biology Technology:International Photonic Integrated Circuit (Monolithic Integration, Hybrid Integration, Module Integration) Market - Forecasts to 2019 2Swell new sensors 2Silicon sponge improves lithium-ion battery performance 2Silicon sponge improves lithium-ion battery performance 3Universities of Surrey and Strathclyde selected as strategic partners in the future operation of the National Physical Laboratory 2Universities of Surrey and Strathclyde selected as strategic partners in the future operation of the National Physical Laboratory 3
... DURHAM, N.C., Dec. 16 Parion Sciences, Inc., ... from the failure of the body,s mucosal defenses, ... have awarded the,company a biodefense grant in excess ... The purpose of the grant is to ...
... KRAS Biomarker PresentsPotential toPersonalize Colorectal Cancer Treatment Determining Who ... , THOUSAND OAKS, Calif., Dec. 16 Amgen ... discuss the clinical utility of the KRAS ... colorectal cancer (mCRC) treated with anti-epidermal growth factor receptor ...
... 16 , - ... The American Journal of Medicine (AJM), one of ... Medicine blog,( http://amjmed.blogspot.com ), a dynamic forum where physicians and ... that have been published in the Journal. , ...
Cached Biology Technology:Parion Sciences Receives NIH Biodefense Grant to Study Novel Methods for Mitigating Radiation-Induced Lung Injury 2Parion Sciences Receives NIH Biodefense Grant to Study Novel Methods for Mitigating Radiation-Induced Lung Injury 3Oncology Biomarker KRAS to be Discussed at FDA Panel Meeting 2Oncology Biomarker KRAS to be Discussed at FDA Panel Meeting 3Oncology Biomarker KRAS to be Discussed at FDA Panel Meeting 4Oncology Biomarker KRAS to be Discussed at FDA Panel Meeting 5Oncology Biomarker KRAS to be Discussed at FDA Panel Meeting 6Oncology Biomarker KRAS to be Discussed at FDA Panel Meeting 7Oncology Biomarker KRAS to be Discussed at FDA Panel Meeting 8Elsevier Introduces The American Journal of Medicine Blog 2Elsevier Introduces The American Journal of Medicine Blog 3
... is the major proteolytic system in ... it catalyzes the selective degradation of ... elimination of proteins with abnormal conformation ... The critical protease in this pathway ...
... [1320] to RFC1 Immunogen Recombinant protein ... Factor C expressed in E. coli. Reactivity ... cerevisiae. Not yet tested in other species. This ... Background Information Replication factor C is ...
... Bacterial DNA Isolation Kit provides a rapid ... genomic DNA from the various bacterial species ... the isolation of genomic DNA from both ... milk samples. ,Purification is based on ...
... Chemicon Select Tissue Arrays are intended for ... tissues were fixed in neutral buffered formalin ... and diagnosis was performed by certified pathologists. ... paraffin blocks and relocated into a new ...
Biology Products: