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NIDCR launches the FaceBase Consortium
Date:10/6/2009

ands of visual images of tissue morphology, or shape, after a specific gene has been disrupted in zebrafish, mice, and other organisms, a standard approach to determine a gene's function. These images then will be linked to molecular data from other studies and these datasets will be made available to the scientific community. Assembling all of these features will take time.

Steven Scholnick, Ph.D., an NIDCR scientist who administers the FaceBase initiative, said the end result of the database and research consortia will be well worth the effort. "If you sketch out the whole consortium on paper, you can easily see how the projects are mutually reinforcing and how interconnecting all of these diverse sets of data can be useful to the entire craniofacial research community individual labs won't have to each invent their own part of the wheel and can instead focus on the bigger, systems-level picture" he said. "It's even more exciting to think that this consortium can lead to collaborations we can't yet envision and that it could accelerate our efforts to help families with children born with craniofacial abnormalities."

The principal investigators on the FaceBase Consortium grants are:

  • Jeffrey C. Murray, University of Iowa and Mary L. Marazita, University of Pittsburgh
    FaceBase Management and Coordination Hub

  • Axel Visel, University of CaliforniaLawrence Berkeley Lab
    Genome-Wide Atlas of Craniofacial Transcriptional Enhancers project

  • Leah Rae Donahue and Stephen Murray, The Jackson Laboratories
    Genetic Tools and Resources for Orofacial Clefting Research project

  • Scott E. Fraser, California Institute of Technology
    Functional Analysis of Neural Crest and Palate: Imaging Craniofacial Development project

  • Linda Shapiro, University of Washington
    Shape-Based Retrieval of 3D Craniofacial Data project

  • David Clouthier and Kristin Bruk Artinger, Uni
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Contact: Bob Kuska
kuskar@nidcr.nih.gov
301-594-7560
NIH/National Institute of Dental and Craniofacial Research
Source:Eurekalert

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