NIBIB invests in quantum research(ng cells as a replacement strategy for t...)

Date:10/5/2007

ng cells as a replacement strategy for treating diabetes. Transplantation of pancreatic islets to restore insulin production is promising; however, the donor pancreata are in short supply and do not meet medical needs. The development of these tissue engineered islets will provide a new source of insulin-producing cells and help realize the full potential of cell therapy for diabetes.

Raoul Kopelman, Ph.D., University of Michigan at Ann Arbor
$2.6 million (3 years)
Nanoparticle Enabled Intraoperative Imaging and Therapy

Brain cancer is one of the most lethal forms of cancer, and is diagnosed in over 43,000 new patients each year. The goal of this project is to improve surgical resection and treatment options for brain cancer patients. Dr. Kopelman and his team will develop nanoparticles that selectively leave the blood and bind to cancer cells. These nanoparticles will aid in the visualization of tumors to allow for maximal surgical resection of tumor mass and also facilitate nonsurgical destruction of the residual cancer cells that are remote or extend from the tumor mass. This may achieve significant improvement in treatment of brain tumors.

Shuvo Roy, Ph.D., Cleveland Clinic Lerner College of Medicine-CWRU
$3.2 million (3 years)
Miniaturized Implantable Renal Assist Device for Total Renal Replacement Therapy

End stage renal disease is a significant global health problem. Donor kidneys for transplantation are in short supply, with dialysis and filtration as the only alternative treatment. This investigator and his team will develop a miniaturized, implantable, and self-regulating bio-artificial kidney that takes the dialysis machinery and integrates it into a miniaturized implantable device. The successful development of this bio-artificial kidney would provide an alternative to the majority of the dialysis procedures performed annually in the U.S.

Mehmet Toner, Ph.D., Massachusetts Gener
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Contact: Cheryl Fee feech@mail.nih.gov 301-451-6772 NIH/National Institute of Biomedical Imaging & Bioengineering Source:Eurekalert

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