Navigation Links
NHLBI grants $1.47 million to study red blood cell transfusion storage times and bioactivity
Date:6/22/2010

BIRMINGHAM, Ala. Researchers in the University of Alabama at Birmingham (UAB) departments of Pathology, Microbiology and Surgery have received a $1.47 million grant from the National Heart, Lung, and Blood Institute (NHLBI) to study so-called red blood cell lesion, a term given to the potentially harmful changes in red blood cells that have been stored for longer times after collection.

The UAB study will focus on the mechanisms by which red blood cell storage time affects blood flow through capillaries, and whether the storage age impacts the interaction between banked red cells and nitric oxide produced in the body.

"We hope to shine a light on the mechanisms behind how red blood cells interact with nitric oxide during circulation to control blood flow and immune response, and see if this control is lost when red cells age in storage," says Rakesh Patel, Ph.D., associate professor of molecular and cellular pathology and lead investigator on the grant.

"The bottom line is we want to know all that we can about the possible negative effects of administering older stored red blood cells, and we hope this information can be used to design therapies to prevent transfusion-related toxicities," Patel says.

Blood processing and storage are known to cause several changes in red blood cell units, including lowering concentrations of molecules that regulate how oxygen is delivered to tissues once transfused. Currently, U.S. Food and Drug Administration regulations allow facilities to store red blood cells for up to 42 days before being transfused. The average age of transfused red blood cells in the United States is estimated to be a little more than 16 days.

UAB researchers will study injured patients in an intensive care unit who need transfusion with one unit of blood. They plan to match the storage age of the blood to several key measurements in recovering trauma patients, including circulation dynamics and inflammation markers in the blood. The grant is a partnership between Patel in the UAB Department of Pathology, Scott Barnum, Ph.D., in the UAB Department of Microbiology, and physicians in the UAB Department of Surgery.

Current data on red blood cell storage times and patient outcomes yield conflicting results. Some studies suggest longer-stored blood units are less effective and more likely to be associated with transfusion-related toxicity caused by red blood cell storage lesion. Other investigators have found no differences in clinical outcomes using red cells stored short-term or long-term.


'/>"/>

Contact: Troy Goodman
tdgoodman@uab.edu
205-934-8938
University of Alabama at Birmingham
Source:Eurekalert

Related biology news :

1. NHLBI awards $11 million for molecular roadmap to chronic lung diseases
2. NHLBI issues first US von Willebrand Disease clinical practice guidelines
3. NIH grants K-State researcher nearly $1.5 million to study antibiotic-resistant bacteria
4. Autism Speaks awards 16 new research grants funding more than $5 million over next 3 years
5. Washington State Life Sciences Discovery Fund awards health research program grants
6. Case Western Reserve University grants option to startup Thermalin Diabetes Inc.
7. Kent State University professors focus research on the environment with grants totaling $890,000
8. Lupus Research Institute announces 2009 novel research grants
9. 2 UNH faculty receive $1.4M in CAREER grants from NSF
10. ASU research efforts to improve human health will get $3 million in federal stimulus grants
11. OU achieves $10 million in stimulus grants for 33 projects on the Norman campus
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/9/2017)... SAN FRANCISCO and MOUNTAIN VIEW, ... Zipongo , "Eating Well Made Simple," and 23andMe ... to help guide better food choices.  Zipongo can now ... only their food preferences, health goals and biometrics, but ... to certain food choices. Zipongo,s personalized food ...
(Date:3/6/2017)... SAN MATEO, Calif. , March 6, 2017 ... predictive marketing and sales technology, today announced Predictive ... (AI) solution for infusing actionable sales intelligence into ... customers to automatically enable their sales organizations with ... contextual messages that allow for intelligent engagement. Predictive ...
(Date:3/2/2017)... -- Who risk to be deprived of its imprint ... https://www.reportbuyer.com/product/4313699/ WILL APPLE AND SAMSUNG CONFRONT ... sensors using capacitive technology represent a fast growing market, ... an increase of 360% of the number of fingerprint ... sensor market between 2014 and 2017 (source : N+1 ...
Breaking Biology News(10 mins):
(Date:3/22/2017)... 22, 2017 MarketNewsUpdates.com News Commentary  ... The traditional ... being pressured as of late due to the rise of ... has a dramatic impact on patient,s quality of life as ... for identifying new forms of opioid formulations that prevent abuse. ...
(Date:3/22/2017)... , March 22, 2017   Boston Biomedical , ... therapeutics designed to target cancer stemness pathways, today announced ... Andrews as Chief Executive Officer, effective April 24, ... Chiang J. Li , M.D., FACP, who has led ... ago. Under his leadership, Boston Biomedical has grown from ...
(Date:3/22/2017)... ... ... Premier executive recruitment firm, Slone Partners, is proud to have been named a Top ... Hunt Scanlon Media is one of the most respected life science publications in the ... sector. , “It is a great honor for Slone Partners to be part of ...
(Date:3/22/2017)... ... March 21, 2017 , ... Proper glycosylation is critical for ... increase and/or decrease in antibody-dependent cellular cytotoxicity or complement-dependent cytotoxicity, there is a ... , To meet this demand, the team at SCIEX has developed a ...
Breaking Biology Technology: