Navigation Links
NHLBI grants $1.47 million to study red blood cell transfusion storage times and bioactivity
Date:6/22/2010

BIRMINGHAM, Ala. Researchers in the University of Alabama at Birmingham (UAB) departments of Pathology, Microbiology and Surgery have received a $1.47 million grant from the National Heart, Lung, and Blood Institute (NHLBI) to study so-called red blood cell lesion, a term given to the potentially harmful changes in red blood cells that have been stored for longer times after collection.

The UAB study will focus on the mechanisms by which red blood cell storage time affects blood flow through capillaries, and whether the storage age impacts the interaction between banked red cells and nitric oxide produced in the body.

"We hope to shine a light on the mechanisms behind how red blood cells interact with nitric oxide during circulation to control blood flow and immune response, and see if this control is lost when red cells age in storage," says Rakesh Patel, Ph.D., associate professor of molecular and cellular pathology and lead investigator on the grant.

"The bottom line is we want to know all that we can about the possible negative effects of administering older stored red blood cells, and we hope this information can be used to design therapies to prevent transfusion-related toxicities," Patel says.

Blood processing and storage are known to cause several changes in red blood cell units, including lowering concentrations of molecules that regulate how oxygen is delivered to tissues once transfused. Currently, U.S. Food and Drug Administration regulations allow facilities to store red blood cells for up to 42 days before being transfused. The average age of transfused red blood cells in the United States is estimated to be a little more than 16 days.

UAB researchers will study injured patients in an intensive care unit who need transfusion with one unit of blood. They plan to match the storage age of the blood to several key measurements in recovering trauma patients, including circulation dynamics and inflammation markers in the blood. The grant is a partnership between Patel in the UAB Department of Pathology, Scott Barnum, Ph.D., in the UAB Department of Microbiology, and physicians in the UAB Department of Surgery.

Current data on red blood cell storage times and patient outcomes yield conflicting results. Some studies suggest longer-stored blood units are less effective and more likely to be associated with transfusion-related toxicity caused by red blood cell storage lesion. Other investigators have found no differences in clinical outcomes using red cells stored short-term or long-term.


'/>"/>

Contact: Troy Goodman
tdgoodman@uab.edu
205-934-8938
University of Alabama at Birmingham
Source:Eurekalert

Related biology news :

1. NHLBI awards $11 million for molecular roadmap to chronic lung diseases
2. NHLBI issues first US von Willebrand Disease clinical practice guidelines
3. NIH grants K-State researcher nearly $1.5 million to study antibiotic-resistant bacteria
4. Autism Speaks awards 16 new research grants funding more than $5 million over next 3 years
5. Washington State Life Sciences Discovery Fund awards health research program grants
6. Case Western Reserve University grants option to startup Thermalin Diabetes Inc.
7. Kent State University professors focus research on the environment with grants totaling $890,000
8. Lupus Research Institute announces 2009 novel research grants
9. 2 UNH faculty receive $1.4M in CAREER grants from NSF
10. ASU research efforts to improve human health will get $3 million in federal stimulus grants
11. OU achieves $10 million in stimulus grants for 33 projects on the Norman campus
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/2/2016)... 2, 2016  BioMEMS devices deployed in ... on medical screening and diagnostic applications, such ... devices that facilitate and assure continuous monitoring ... are being bolstered through new opportunities offered ... acquisition coupled with wireless connectivity and low ...
(Date:2/2/2016)... NEW YORK , Feb. 2, 2016 /PRNewswire/ ... Potentials of that Rising Market Are you ... new analysis forecasts revenues for checkpoint inhibitors. Visiongain,s ... world market, submarket, product and national level. ... Instead discover what progress, opportunities and revenues those ...
(Date:2/2/2016)... RESTON, Va. , Feb. 2, 2016 /PRNewswire/ ... contract award from the U.S. Army Research Office ... extend the range and sensitivity of the company,s ... DoD,s Past Accounting Mission and, more generally, defense-related ... its DNA phenotyping capabilities (predicting appearance and ancestry ...
Breaking Biology News(10 mins):
(Date:2/9/2016)... ... ... The American Academy of Thermology (AAT) has announced that for the ... Qualification Course for Technicians via a two part webinar on July 30 and August ... of hardware, software, and camera setup/operations, aligns with the in-person member qualification course that ...
(Date:2/9/2016)... (PRWEB) , ... February 09, 2016 , ... ... former Vice President for Public Policy for the National Organization for Rare Disorders ... advocacy groups to ensure their voices are heard throughout the drug regulatory review ...
(Date:2/9/2016)... NEW YORK , Feb. 9, 2016 ... market analyzes the current and future prospects of the ... of this report include companies engaged in the manufacture ... comprises an executive summary with a market snapshot providing ... the scope of this report. This section also provides ...
(Date:2/9/2016)... , February 9, 2016 Three-Year Initiative ... Children to Take Part in Life-Changing Camp ... initiative designed to positively affect the lives of children born with ... --> SHPG ) is announcing a new initiative designed ... as well as the future of rare disease care. --> ...
Breaking Biology Technology: