Navigation Links
NHLBI grants $1.47 million to study red blood cell transfusion storage times and bioactivity
Date:6/22/2010

BIRMINGHAM, Ala. Researchers in the University of Alabama at Birmingham (UAB) departments of Pathology, Microbiology and Surgery have received a $1.47 million grant from the National Heart, Lung, and Blood Institute (NHLBI) to study so-called red blood cell lesion, a term given to the potentially harmful changes in red blood cells that have been stored for longer times after collection.

The UAB study will focus on the mechanisms by which red blood cell storage time affects blood flow through capillaries, and whether the storage age impacts the interaction between banked red cells and nitric oxide produced in the body.

"We hope to shine a light on the mechanisms behind how red blood cells interact with nitric oxide during circulation to control blood flow and immune response, and see if this control is lost when red cells age in storage," says Rakesh Patel, Ph.D., associate professor of molecular and cellular pathology and lead investigator on the grant.

"The bottom line is we want to know all that we can about the possible negative effects of administering older stored red blood cells, and we hope this information can be used to design therapies to prevent transfusion-related toxicities," Patel says.

Blood processing and storage are known to cause several changes in red blood cell units, including lowering concentrations of molecules that regulate how oxygen is delivered to tissues once transfused. Currently, U.S. Food and Drug Administration regulations allow facilities to store red blood cells for up to 42 days before being transfused. The average age of transfused red blood cells in the United States is estimated to be a little more than 16 days.

UAB researchers will study injured patients in an intensive care unit who need transfusion with one unit of blood. They plan to match the storage age of the blood to several key measurements in recovering trauma patients, including circulation dynamics and inflammation markers in the blood. The grant is a partnership between Patel in the UAB Department of Pathology, Scott Barnum, Ph.D., in the UAB Department of Microbiology, and physicians in the UAB Department of Surgery.

Current data on red blood cell storage times and patient outcomes yield conflicting results. Some studies suggest longer-stored blood units are less effective and more likely to be associated with transfusion-related toxicity caused by red blood cell storage lesion. Other investigators have found no differences in clinical outcomes using red cells stored short-term or long-term.


'/>"/>

Contact: Troy Goodman
tdgoodman@uab.edu
205-934-8938
University of Alabama at Birmingham
Source:Eurekalert

Related biology news :

1. NHLBI awards $11 million for molecular roadmap to chronic lung diseases
2. NHLBI issues first US von Willebrand Disease clinical practice guidelines
3. NIH grants K-State researcher nearly $1.5 million to study antibiotic-resistant bacteria
4. Autism Speaks awards 16 new research grants funding more than $5 million over next 3 years
5. Washington State Life Sciences Discovery Fund awards health research program grants
6. Case Western Reserve University grants option to startup Thermalin Diabetes Inc.
7. Kent State University professors focus research on the environment with grants totaling $890,000
8. Lupus Research Institute announces 2009 novel research grants
9. 2 UNH faculty receive $1.4M in CAREER grants from NSF
10. ASU research efforts to improve human health will get $3 million in federal stimulus grants
11. OU achieves $10 million in stimulus grants for 33 projects on the Norman campus
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/20/2016)... 2016  VoiceIt is excited to announce its ... By working together, VoiceIt and VoicePass will ... VoicePass take slightly different approaches to voice biometrics, ... and usability. ... partnership. "This marketing and technology partnership ...
(Date:5/3/2016)... May 3, 2016  Neurotechnology, a provider of ... MegaMatcher Automated Biometric Identification System (ABIS) , a ... projects. MegaMatcher ABIS can process multiple complex biometric ... combination of fingerprint, face or iris biometrics. It ... and MegaMatcher Accelerator , which have ...
(Date:4/26/2016)... April 27, 2016 Research ... Multi-modal Biometrics Market 2016-2020"  report to their offering.  ... The analysts forecast the global multimodal ... 15.49% during the period 2016-2020.  Multimodal ... sectors such as the healthcare, BFSI, transportation, automotive, ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... ... June 27, 2016 , ... Rolf K. Hoffmann, ... faculty of the University of North Carolina Kenan-Flagler Business School effective ... at UNC Kenan-Flagler, with a focus on the school’s international efforts, leading classes ...
(Date:6/24/2016)... June 24, 2016  Regular discussions on a range of ... between the two entities said Poloz. Speaking at ... Ottawa , he pointed to the country,s inflation target, ... government. "In certain ... institutions have common economic goals, why not sit down and ...
(Date:6/24/2016)... ... June 24, 2016 , ... Researchers at the Universita Politecnica delle Marche in ... peritoneal or pleural mesothelioma. Their findings are the subject of a new article on ... biomarkers are signposts in the blood, lung fluid or tissue of mesothelioma patients that ...
(Date:6/23/2016)... CAMBRIDGE, Mass. , June 23, 2016 /PRNewswire/ ... the development of novel compounds designed to target ... compound, napabucasin, has been granted Orphan Drug Designation ... in the treatment of gastric cancer, including gastroesophageal ... cancer stemness inhibitor designed to inhibit cancer stemness ...
Breaking Biology Technology: