NHGRI seeks DNA sequencing technologies fit for routine laboratory and m...(-term technologies to sequence a genome ...)

Date:8/20/2008

-term technologies to sequence a genome for $100,000. The collective approaches incorporate many complementary elements that integrate biochemistry, chemistry and physics with engineering to enhance the whole effort to develop the next generation of DNA sequencing and analysis technologies.

"$1,000 Genome" Grants

NHGRI's Revolutionary Genome Sequencing Technologies grants have as their goal the development of breakthrough technologies that will enable a human-sized genome to be sequenced for $1,000 or less. Grant recipients and their approximate total funding are:

Daniel Branton, Ph.D., Jene A. Golovchenko, Ph.D., Harvard University, Cambridge, Mass.
$6.5 million (4 years)
Electronic Sequencing in Nanopores

Several groups are developing nanopores (holes about two nanometers in diameter) that may be able to recognize individual DNA bases by their electrical or ionic signals to achieve high-accuracy sequencing of individual DNA molecules. The goal of this group is to design and optimize nanopore technology using novel electronic control and sensing methods to eventually lead to a nanopore detector chip capable of sequencing a mammalian genome within a day on a single instrument.

Stephen Y. Chou, Ph.D., Princeton University, Princeton, New Jersey
$920,000 (3 years)
Nanogap Detector (Arrays) Inside Nanofluidic Channels for Fast Real-Time DNA Sequencing

A nanometer is one-billionth of a meter, much too small to be seen with a conventional lab microscope. This group will explore using a nanochannel that includes a nanogap detector sensitive enough to identify DNA base pairs by their electrical signals as a single DNA molecule is moved through the device, eliminating the costly step of amplifying or labeling the DNA. The focus of the initial work is to develop techniques for fabricating nanogap detectors with improved sensitivity and functionality.

Marija Drndic, Ph.D., Universit
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Contact: Geoff Spencer spencerg@mail.nih.gov 301-402-0911 NIH/National Human Genome Research Institute Source:Eurekalert

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