About nine out of 10 new cancer drugs successfully clear preclinical development hurdles, but then they fail in human clinical testing. A new partnership facilitated by SAIC-Frederick Inc. aims to help change that outcome.
The partnership brings together The UC Davis Cancer Center, The Jackson Laboratory and the National Cancer Institute's (NCI) Center for Advanced Preclinical Research (CAPR), all under the umbrella of NCI's Advanced Technology Partnerships Initiative (ATPI). SAIC-Frederick facilitates translational research and development partnerships in cancer and AIDS for the ATPI as part of its longstanding operations and technical support contract with NCI.
Under the partnership, a range of genetically engineered and human transplant mouse model studies will be integrated with patient treatment clinical trial studies under a uniform and controlled testing mechanism. Data resulting from this combined approach will help identify molecules (biomarkers) that could predict conditions under which candidate drugs will be most effective. These data could be invaluable for designing clinical trials and improving treatment outcomes.
The new approach has been named the iGXT Platform for integrated genetically engineered mouse models (GEMMs)/patient-derived tumor Xenograft models (PDXs)/clinical Trials.
The partnership draws on particular strengths of each organization. The Center for Advanced Preclinical Research (CAPR) brings expertise in engineered mouse models. The Jackson Laboratory adds experience in human transplant models, and UC Davis contributes extensive knowledge of cancer drug clinical trials and laboratory resources.
NCI's work under the platform will be conducted at the Center for Advanced Preclinical Research (CAPR) in Frederick, Md. NCI-Frederick is a government-owned, contract-operated federal national laboratory with SAIC-Frederick as prime contractor.
The iGXT Platform was presented at the
|Contact: Joyce Peterson|