Navigation Links
NASH diagnosis set to improve with non-invasive tool
Date:4/24/2013

  • A Chinese study presented at the International Liver CongressTM 2013 has demonstrated the accuracy of a non-invasive test for non-alcoholic steatohepatitis (NASH) diagnosis.

  • Non Alcoholic Fatty Liver disease (NAFLD) comprises two groups of patients; one group with simple steatosis which is relatively benign and one group with NASH which may progress to cirrhosis and hepatocellular carcinoma. Up to now the only means of distinguishing the two was to perform a liver biopsy. Phosphorus magnetic resonance spectroscopy (31P-MRS), which allows non-invasive in vivo assessment of hepatocellular metabolism, was proven to show potential to distinguish the type of NAFLD.

  • The accuracy of the imaging technique could improve clinical procedures and enhance patient experience compared to the discomfort and risk of undergoing the 'gold standard' test (liver biopsy) currently used for diagnosing NAFLD. These results will now need to be prospectively confirmed in independent cohorts.

  • NASH is a more advanced form of NAFLD and its incidence and prevalence is rising. Although CT and ultrasound scans are potential diagnostic tools for NAFLD, currently only liver biopsy can confirm whether the simpler NAFLD is present or whether the more serious NASH has developed.

  • Using 31PMRS, the liver metabolite changes from 132 patients with biopsy-proven NAFLD were obtained and the diagnostic performance of 31P-MRS for NASH was determined.

  • 31P-MRS shows distinct alterations in ATP and PDE levels which are concordant with putative mechanisms in the progression of NAFLD. 31P-MRS shows fair diagnostic accuracy for NAFLD compared with liver biopsy, and using certain thresholds can be considered a reliable diagnostic tool for NASH.


'/>"/>

Contact: Dimple Natali
easlpressoffice@cohnwolfe.com
44-079-001-38904
European Association for the Study of the Liver
Source:Eurekalert

Page: 1

Related biology news :

1. Hand-held device cheaply, quickly diagnosis malaria
2. In autism, age at diagnosis depends on specific symptoms
3. European Guidance for the diagnosis & management of osteoporosis in postmenopausal women
4. Rapid, point-of-care tests for syphilis: The future of diagnosis
5. A genetic device performs DNA diagnosis
6. MicroRNAs present exciting opportunities for cancer therapy and diagnosis
7. An international competition reaffirms the potential of bioinformatics in the diagnosis of disease
8. Detection, analysis of cell dust may allow diagnosis, monitoring of brain cancer
9. Privately owned genetic databases may hinder diagnosis and bar the way to the arrival of personalized medicine
10. Plants provide accurate low-cost alternative for diagnosis of West Nile Virus
11. Obesity is major contributor to heart disease, impediment to diagnosis and treatment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/17/2018)... ... October 17, 2018 , ... ... medicine, or to patients, say 65 percent of physicians surveyed by MDLinx, a ... from a variety of medical specialties revealed that many physicians are frustrated with ...
(Date:10/16/2018)... ... October 16, 2018 , ... ... for biopharmaceutical R&D, today announced Genedata Imagence®, the industry’s first commercial and ... deep learning-based solution accelerates, by orders of magnitude, the time-consuming and complex ...
(Date:10/16/2018)... ... 2018 , ... Our own cells may be the answer to eliminating chronic ... interventional spine and pain management specialist Jason Arora, DO, who says using a patient’s ... from a patient’s bone marrow are proving effective therapies for eliminating discogenic pain, namely ...
Breaking Biology News(10 mins):
(Date:10/16/2018)... , ... October 16, 2018 , ... ... attended the first Congressional briefing on a revolutionary technology that effectively treats pain, ... founder of Infinity Healing, testified on how technology using photobiomodulation (PBM) has been ...
(Date:10/11/2018)... BOSTON (PRWEB) , ... October 10, 2018 , ... ... for the biotech community, announces the appointment of Wendy Nelson, PhD, as its ... management, operational and R&D experience in the biotech industry. Most recently, Dr. ...
(Date:10/5/2018)... Calif. (PRWEB) , ... October 04, 2018 , ... ... disease diagnostics with genomics, along with Duke University, announced today at IDWeek™ 2018 ... blood test that detects pathogen DNA in plasma, accurately identified causative pathogens in ...
(Date:10/2/2018)... ... October 02, 2018 , ... ... biopharmaceutical R&D, today announced a new out-of-the-box integration of the Genedata ... international pharmaceutical and laboratory equipment supplier. This enables the automatic import of ...
Breaking Biology Technology: