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NASA researchers find clues to a secret of life
Date:3/17/2009

GREENBELT, Md. - NASA scientists analyzing the dust of meteorites have discovered new clues to a long-standing mystery about how life works on its most basic, molecular level.

"We found more support for the idea that biological molecules, like amino acids, created in space and brought to Earth by meteorite impacts help explain why life is left-handed," said Dr. Daniel Glavin of NASA's Goddard Space Flight Center in Greenbelt, Md. "By that I mean why all known life uses only left-handed versions of amino acids to build proteins." Glavin is lead author of a paper on this research appearing in the Proceedings of the National Academy of Sciences March 16.

Proteins are the workhorse molecules of life, used in everything from structures like hair to enzymes, the catalysts that speed up or regulate chemical reactions. Just as the 26 letters of the alphabet are arranged in limitless combinations to make words, life uses 20 different amino acids in a huge variety of arrangements to build millions of different proteins. Amino acid molecules can be built in two ways that are mirror images of each other, like your hands. Although life based on right-handed amino acids would presumably work fine, "you can't mix them," says Dr. Jason Dworkin of NASA Goddard, co-author of the study. "If you do, life turns to something resembling scrambled eggs -- it's a mess. Since life doesn't work with a mixture of left-handed and right-handed amino acids, the mystery is: how did life decide -- what made life choose left-handed amino acids over right-handed ones?"

Over the last four years, the team carefully analyzed samples of meteorites with an abundance of carbon, called carbonaceous chondrites. The researchers looked for the amino acid isovaline and discovered that three types of carbonaceous meteorites had more of the left-handed version than the right-handed variety as much as a record 18 percent more in the often-studied Murchison meteorite. "Find
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Contact: Bill Steigerwald
william.a.steigerwald@nasa.gov
301-286-5017
NASA/Goddard Space Flight Center
Source:Eurekalert  

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