NAS report offers new tools to assess health risks from...( Determining how thousands of chemica...)

Determining how thousands of chemicals found in the environment may be interacting with the genes in your body to cause disease is becoming easier because of a new field of science called toxicogenomics. A new report issued today by the National Academies of Sciences (NAS) recognizes the importance of toxicogenomics in predicting effects on human health and recommends the integration of toxicogenomics into regulatory decision making. The NAS report was commissioned by the National Institute of Environmental Health Sciences (NIEHS) part of the National Institutes of Health (NIH) and a leader in the development of toxicogenomic technologies.

Toxicogenomic technologies provide tools to better understand the mechanisms through which environmental agents initiate and advance disease processes. They can also provide important information to help identify individuals that are more susceptible to disease risks posed by certain environmental agents than the general population.

Using toxicogenomic technologies will open the door for public health decision makers who need to decide in a timely and accurate manner what chemicals are safe and which ones are not, says Christopher Portier, Ph.D., Associate Director, NIEHS and Director, Office of Risk Assessment Research.

The report from the NAS National Research Council (NRC) entitled Applications of Toxicogenomic Technologies to Predictive Toxicology and Risk Assessment states that the technological hurdles that could have limited the reproducibility of data from toxicogenomic technologies have been resolved and recommends ways for the field to move forward.

NIH and others have invested in the development of these tools and have already tackled many of the tough technical questions. We are now ready to move to the next phase of technology development, refined standardization and validation, so these tools can be even more useful to regulatory agencies, says Portier.

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