Navigation Links
Mystery unraveled: How asbestos causes cancer
Date:6/29/2010

More than 20 million people in the U.S., and many more worldwide, who have been exposed to asbestos are at risk of developing mesothelioma, a malignant cancer of the membranes that cover the lungs and abdomen that is resistant to current therapies. Moreover, asbestos exposure increases the risk of lung cancer among smokers. For the past 40 years researchers have tried to understand why asbestos causes cancer.

The answer appears in a study published in the current issue of the Proceedings of the National Academy of Sciences, U.S.A., Drs. Haining Yang and Michele Carbone at the University of Hawai'i Cancer Research Center led a research team that included collaborators at New York University, University of Chicago, University of Pittsburgh, San Raffaele University of Milano, and the Imperial College in London.

These researchers addressed the paradox of how asbestos fibers that kill cells could cause cancer, since a dead cell should not be able to grow and form a tumor. They found that when asbestos kills cells, it does so by inducing a process called "programmed cell necrosis" that leads to the release of a molecule called high-mobility group box 1 protein (HMGB1). HMGB1 starts a particular type of inflammatory reaction that causes the release of mutagens and factors that promote tumor growth. The researchers found that patients exposed to asbestos have elevated levels of HMGB1 in their serum. Therefore, they state that it may be possible to target HMGB1 to prevent or treat mesothelioma and identify asbestos-exposed cohorts by simple HMGB1 serological testing.

In the article, the researchers propose that by interfering with the inflammatory reaction caused by asbestos and HMGB1, it may be possible to decrease cancer incidence among cohorts exposed to asbestos and decrease the rate of tumor growth among those already affected by mesothelioma. Drs. Yang and Carbone, the lead authors, state that to test this hypothesis, they ar
'/>"/>

Contact: Sharon Shigemasa
Sharon@crch.hawaii.edu
808-586-3011
University of Hawaii at Manoa
Source:Eurekalert

Page: 1 2

Related biology news :

1. Answer to saliva mystery has practical impact
2. Solution to beading-saliva mystery has practical purposes
3. Uncovering the mystery of a major threat to wheat
4. A Dicty mystery solved
5. Scripps Research scientists solve mystery of fragile stem cells
6. Experts gather to solve mystery of largest recorded die-off of great whales
7. U-M researchers solve a molecular mystery in muscle
8. Scientists unlock mystery in important photosynthesis step
9. Brown biologist solves mystery of tropical grasses origin
10. Green plant transport mystery solved
11. Coal from mass extinction era linked to lung cancer mystery
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/10/2014)... --Research and Markets ( http://www.researchandmarkets.com/research/xclcvw/biometrics_market ) ... Market in Japan 2014-2018" report to their ... The integration of biometrics and smart ... upgradation of the driver,s license is one of ... the aforementioned projects, biometrics is being used as ...
(Date:12/5/2014)... VIEW, Calif. , Dec. 4, 2014 /PRNewswire/ ... safety has boosted investments in new testing and ... has also given rise to a range of ... by the requirements of Generation Y, which is ... technologies. As a result, product development strategies of ...
(Date:12/4/2014)... BEACH GARDENS, Fla. , Dec. 3, 2014 ... management solutions, today announced that its DigitalPersona ® ... 4500 fingerprint readers have been deployed throughout First ... , South Carolina ... headquartered in Southern Pines, North Carolina ...
Breaking Biology News(10 mins):Biometrics Market in Japan 2014-2018: Key Vendors are DDS, Fujitsu, Hitachi and NEC 2Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 2Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 3Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 4First Bank Partners with Crossmatch to Increase Log In Security 2First Bank Partners with Crossmatch to Increase Log In Security 3
... and water experts have converged at Nanyang Technological University ... research community on a scarce natural resource -- water. ... in the last fortnight as they attended the inaugural ... Last week, the university also hosted the 4th GlobalTech ...
... and Boston, MA. Wed. July 4, 2012 One of ... treatment. In the case of many forms of cancer, including ... cancer cells in the lab, but often produce only partial, ... the field of cancer research has been and remains: how ...
... researchers have discovered that recent climate change is causing leaves ... study, which is the first of its kind in the ... in climate. The results are published online today in ... Researchers analysed leaves from herbarium specimens of Narrow-leaf Hopbush ...
Cached Biology News:Wholly water -- students and scientists gather at NTU to discuss water problem 2Wholly water -- students and scientists gather at NTU to discuss water problem 3Wholly water -- students and scientists gather at NTU to discuss water problem 4Wholly water -- students and scientists gather at NTU to discuss water problem 5Tumor microenvironment helps skin cancer cells resist drug treatment 2Tumor microenvironment helps skin cancer cells resist drug treatment 3Tumor microenvironment helps skin cancer cells resist drug treatment 4Shrinking leaves point to climate change 2
(Date:12/22/2014)... Dec. 22, 2014  ( www.competitivehealth.com ) — Competitive ... medical bill review and advocacy service, has signed an ... WellCard Savings discount health services marketplace. 63% ... more than they expected to pay. As part of ... costs, WellCard Savings is pleased to offer medical bill ...
(Date:12/22/2014)... 22, 2014 Fertility Associates of Memphis ... Bank USA , a network of more than 20 ... partnership, patients have fast access to a national pool ... IVF . Fertility Associates of Memphis is the only ... treatment option. , Dr. William Kutteh , director ...
(Date:12/19/2014)... BioPlus Specialty Pharmacy (BioPlus), one ... of Nick Maroulis, Pharm.D. to the newly created position ... In this position, Dr. Maroulis will continue to manage ... of our multi-site pharmacies as the company expands. Dr. ... that time he has served in many different capacities ...
(Date:12/19/2014)... Dec. 19, 2014 Bina Technologies, Inc. (Bina, ... that they have been acquired by Roche (SIX: RO, ... privately held company that provides a big data platform ... (NGS) data for the academic and translational research markets. ... and will continue to focus on development of their ...
Breaking Biology Technology:WellCard Savings Announces CoPatient Medical Bill Review Service for Members 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 3BioPlus Specialty Pharmacy Promotes Dr. Nick Maroulis to Vice President of Specialty Pharmacy Services 2Bina Technologies is acquired by Roche. 2Bina Technologies is acquired by Roche. 3
... review demonstrates bioidentical hormones are superior to synthetic ... of breast cancerTORRANCE, Calif., Feb. 23 The ... Postgraduate Medical Journal, a leading peer-reviewed publication for ... with reduced health risks and are more efficacious ...
... - Sirius Genomics, a developer of a pharmacogenomic test ... (sold by Eli Lilly and Company under the trademark ... CEO, will present at the annual Invest Northwest Investor-CEO ... PST. The conference is presented by the Washington Biotechnology ...
... Netherlands, Feb. 23 Schering-Plough Corporation (NYSE: ... between Nobilon, Schering-Plough,s human vaccine business unit, and ... to pandemic influenza vaccine manufacturing technology to developing ... demonstrates Schering-Plough,s strong commitment to innovation and to ...
Cached Biology Technology:New Analysis Finds Bioidentical Hormones Safer Than Standard Hormone Replacement Therapy 2New Analysis Finds Bioidentical Hormones Safer Than Standard Hormone Replacement Therapy 3Sirius Genomics to Present at Invest Northwest Conference 2Schering-Plough Announces Collaboration With World Health Organization to Provide Access to Pandemic Influenza Vaccine Technology to Developing Countries 2Schering-Plough Announces Collaboration With World Health Organization to Provide Access to Pandemic Influenza Vaccine Technology to Developing Countries 3
... protein A media yield highly purified ... to analysis of other immunoglobulin classes, ... purification. Protein A binds to the ... from mammalian species. This ready-to-use, bottled ...
... bis- (3-D-Gluconamidopropyl)deoxycholamide White solid. HYGROSCOPIC. ... CHAPSO. Has reduced electrostatic interactions that do ... DEAE-cellulose. Aggregation number: 8-16. Purity: ≥95% ... O. Aggregation number 8 - 16, CMC ...
Goat Anti-Horse IgG(T) Antibody, Unconjugated...
Goat polyclonal to STMN2 ( Abpromise for all tested applications). Antigen: Synthetic peptide: AKTAMAYKEK, corresponding to C terminal amino acids 2-11 of STMN2. Entrez Gene ID: 11075 Swi...
Biology Products: