Navigation Links
Mystery to the origin of long-lived, skin-deep immune cells uncovered
Date:6/7/2012

Scientists at A*STAR's Singapore Immunology Network (SIgN) uncovered the origin of a group of skin-deep immune cells that act as the first line of defence against harmful germs and skin infections. SIgN scientists discovered that these sentry cells of the skin, called the Langerhans cells (LCs), originate from two distinct embryonic sites - the early yolk sac and the foetal liver.

LCs are dendritic cells (DCs) found in the outermost layer of the skin. DCs are a critical component of the immune system because they are the only cells able to 'see' and 'alert' other responding immune cells to initiate a protective response against harmful foreign invaders. Like sentries of the immune system, DCs are strategically positioned where they are likely to encounter harmful pathogens. Identifying the source of these specialised immune cells may hold exciting possibilities to novel strategies for vaccination and treatment of autoimmune diseases and inflammatory skin disorders.

In contrast to other DCs which are constantly replaced by a circulating pool of bone marrow-derived precursors, LCs has the interesting ability to maintain themselves throughout life. While it is established that these long-lived sentry cells of the skin arise from precursors that are recruited to the skin prior to birth, this is the first time that the exact origin of the precursors of LCs is revealed through advanced fate-mapping technique (a method of tracing cell lineages to their embryonic origin).

In this study, published in the June issue of Journal of Experimental Medicine, Dr Florent Ginhoux, and his team demonstrated that adult LCs originate from two distinct embryonic lineages in two succeeding waves. The first wave of precursor cells from the yolk sac 'seed' the skin before the onset of the foetal liver. Interestingly, the team discovered that at the later stage of development, the yolk-sac precursors are largely replaced by a type of white blood cells from the foetal liver.

Said Dr Ginhoux, Principal Investigator of SIgN, "Whether this unique dual origin of Langerhans cells influences their ability to maintain skin integrity or dictate their specialised immune functions in response to microbes and vaccines needs to be examined. But having identified their origin surely opens new possibilities of using them as novel vaccination strategies or as therapeutic tool for treating inflammatory skin diseases like psoriasis."

Scientific Director of SIgN, Professor Paola Castagnoli said, "This discovery sheds light on understanding the complexities of the immune system, in particular the relationship between immune responses and human diseases. It will bring us closer to our goal of discovering novel ways of treating and preventing a range of immune diseases that will impact healthcare."
'/>"/>

Contact: Dr. Sarah Chang
chang_kai_chen@a-star.edu.sg
65-682-66442
Agency for Science, Technology and Research (A*STAR), Singapore
Source:Eurekalert

Related biology news :

1. UCLA life scientists unlock mystery of how handedness arises
2. Kidney stone mystery solved
3. Virginia Tech and University of Tuscia lead team to unravel origin of devastating kiwifruit bacterium
4. Breast-fed babies gut microbes contribute to healthy immune systems
5. New screening technique yields elusive compounds to block immune-regulating enzyme
6. Immune-response genes affecting breast tumor eradication
7. Carnegie Mellon fluorescent biosensor reveals mechanism critical to immune system amplification
8. New genetic mechanism of immune deficiency discovered
9. New immune defense enzyme discovered
10. Key to immune system disease could lie inside the cheek
11. Immune system implicated in prematurity complication
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/28/2017)... , March 28, 2017 The ... Hardware (Camera, Monitors, Servers, Storage Devices), Software (Video Analytics, ... Region - Global Forecast to 2022", published by MarketsandMarkets, ... 2016 and is projected to reach USD 75.64 Billion ... and 2022. The base year considered for the study ...
(Date:3/24/2017)... 24, 2017 The Controller General of Immigration from ... Abdulla Algeen have received the prestigious international IAIR Award for the ... Continue Reading ... ... Controller Abdulla Algeen (small picture on the right) have received the IAIR ...
(Date:3/23/2017)... The report "Gesture Recognition and Touchless Sensing Market by Technology (Touch-based ... to 2022", published by MarketsandMarkets, the market is expected to be worth USD ... 2022. Continue Reading ... ... ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... and LAGUNA HILLS, Calif. , Oct. ... Cancer Research, London (ICR) and University ... SKY92, SkylineDx,s prognostic tool to risk-stratify patients with multiple myeloma ... MUK nine . The University of Leeds ... partly funded by Myeloma UK, and ICR will perform the ...
(Date:10/10/2017)... ... 2017 , ... San Diego-based team building and cooking events company, Lajollacooks4u, has ... The bold new look is part of a transformation to increase awareness, appeal to ... period. , It will also expand its service offering from its signature gourmet cooking ...
(Date:10/10/2017)... 10, 2017 International research firm Parks Associates announced ... at the TMA 2017 Annual Meeting , October 11 in ... residential home security market and how smart safety and security products impact ... Parks Associates: Smart Home ... "The residential security market has ...
(Date:10/9/2017)... DIEGO , Oct. 9, 2017  BioTech ... biological mechanism by which its ProCell stem cell ... critical limb ischemia.  The Company, demonstrated that treatment ... amount of limbs saved as compared to standard ... the molecule HGF resulted in reduction of therapeutic ...
Breaking Biology Technology: