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Mystery solved: Facial cancer decimating Tasmanian devils likely began in Schwann cells
Date:12/31/2009

mined the identity of the originating cell by using advanced sequencing technology to uncover the tumors' "transcriptome" the complete set of genes that are turned on in tumor cells. Comparing this readout to that from other tissues, the team found that the tumors' genetic signature best matched that of Schwann cells. How these nervous system cells spawned cancer is still a mystery.

"Now that we've taken a good look at the tumors' genetic profile, we can start hunting for genes and pathways involved in tumor formation," says Hannon. The team has also compiled a catalogue of devil genes that might influence the pathology and transmission of the tumor -- information that will be very useful in designing vaccines and other therapeutic strategies.


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Contact: Hema Bashyam
bashyam@cshl.edu
516-367-6822
Cold Spring Harbor Laboratory
Source:Eurekalert

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