Navigation Links
Mysterious snake disease decoded
Date:8/14/2012

the virus went into overdrive after Stenglein joined the DeRisi laboratory as a postdoctoral fellow and took on the project. But before he and DeRisi could find traces of the virus they needed to know the sequence of the boa constrictor genome so they could distinguish snake DNA sequences from viral sequences in the diseased animals. The problem was that there were no snake genomes available.

Thus, their first step was to sequence the entire boa constrictor genome, and they had to start with a snake that they were sure was free of inclusion body disease. At the Academy, Dunker helped in this effort by collecting blood from a boa constrictor named Balthazar, an education animal which was housed separately, had no contact with the rest of the boa snake collection and tested negative for the inclusion body disease.

Substantial help in the sequencing effort came from scientists participating in a friendly competition called the Assemblathon 2, which was sponsored by UC Santa Cruz and UC Davis. Balthazar's DNA was sequenced and a number of groups around the country competed to build (assemble) the most complete genome sequence possible using the raw data.

Characterizing Balthazar's genome paved the way for finding the arenavirus in the midst of millions of other sequences of the snakes' DNA. This "needle in the haystack" problem was solved using custom software written in the DeRisi lab, and made available for free on his website.

This is where the shock came.

The team found two arenavirus strains in the snakesa surprise in itself; but in addition, they observed that theviruses did not look like your ordinary arenaviruses. They looked like distant relatives of other arenaviruses but had protein coats that were more similar to those of Ebola viruses. Like arenaviruses, Ebola virus can cause fatal hemorrhagic fever when transmitted to humans. Neither of those viruses has ever been known to infect reptiles, and although it ha
'/>"/>

Contact: Jennifer O'Brien
jennifer.obrien@ucsf.edu
415-502-6397
University of California - San Francisco
Source:Eurekalert  

Page: 1 2 3 4 5

Related biology news :

1. Gene discovery set to help with mysterious paralysis of childhood
2. Life cycles of mysterious Namibian grassland fairy circles characterized
3. Scientists discover new type of virus responsible for a devastating disease in snakes
4. Big-mouthed babies drove the evolution of giant island snakes
5. Taking Americas rarest snake back to the woods
6. Robosquirrels versus rattlesnakes
7. New paper examines poison resistance in snakes around the world
8. UC research: Tracking Lake Erie water snake in fight against invasive fish
9. 10 new diabetes gene links offer picture of biology underlying disease
10. The Johns Hopkins Center for Inherited Disease Research receives $101 million
11. Scripps Research Institute scientists show copper facilitates prion disease
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Mysterious snake disease decoded
(Date:10/16/2014)... Northridge, Calif. (October 16, 2014) – Post-menopausal women ... effect on hormone levels or genital bleeding, after ... of an investigational fermented soy germ-based nutritional supplement ... according to a new peer-reviewed pilot study reported ... Society (NAMS) annual scientific meeting. , "These ...
(Date:10/15/2014)... the pandemic risk from strains of influenza virus increases ... ourselves to become complacent that the most substantial threats ... , Influenza pandemics arise when a new virus strain ... immunity – spreads in the human population. There have ... the worst of which – the 1918 Spanish Flu ...
(Date:10/15/2014)... The Ebola virus is spreading rapidly and to an ... experienced in the past and the virus shows a ... been recorded before. For this reason, the German National ... of Science and Engineering, and the Union of the ... statement on the Ebola epidemic today. , In the ...
Breaking Biology News(10 mins):S-equol supplements associated with improved measures of reproductive health in postmenopausal women 2Scientists 'must not become complacent' when assessing pandemic threat from flu viruses 2Academies call for consequences from the Ebola virus epidemic 2Academies call for consequences from the Ebola virus epidemic 3Academies call for consequences from the Ebola virus epidemic 4Academies call for consequences from the Ebola virus epidemic 5
... invites all journalists to attend its 64th Annual Scientific ... field of aging from November 18 to 22 ... charge. An estimated 3,500 professionals are expected to ... Veterans Memorial Convention Center and Sheraton Boston Hotel. The ...
... Later this week, the American Society of Plant Biologists (ASPB) ... to chart the future of the field. The Plant ... plant science research community in a process that will develop ... over the next decade. The summit will bring together ...
... researchers could help develop culturally appropriate conservation efforts and ... southwest China where deforestation is a major environmental issue. ... Religion and the Cultural Studies program, and An Jing, ... Studies, found a distinct link between the strong religious ...
Cached Biology News:Join GSA in Boston for the nation's premier aging conference 2ASPB convenes leaders to chart future of plant science research 2Religion and ecology among China's Blang people 2
(Date:10/22/2014)... San Diego, CA (PRWEB) October 22, 2014 ... laboratory balances from Sartorius, A & D Weighing, ... Sartorius CPA Semi-Micro Balance . The Sartorius ... looking for an affordable high-quality, precise, and user-friendly ... in manufacturing of laboratory equipment, their laboratory balances ...
(Date:10/22/2014)... October 22, 2014 According to ... by Service Type (Consulting, Integration, Deployment & Support), ... Deployment Model (Public, Private, Others (Hybrid & Community)) ... defines and segments the Cloud Professional Services Market ... forecasting of revenues. It also identifies the drivers ...
(Date:10/22/2014)... Oct. 22, 2014 Nuvilex, Inc. (OTCQB: NVLX) ... million people worldwide are living with diabetes, with  that ... 2030.  The global market for diabetes treatments is approximately ... people worldwide died from pancreatic cancer.  Pancreatic cancer is ... cancer in the United States , ...
(Date:10/20/2014)... (PRWEB) October 20, 2014 The ... (Medication Dispensing Systems, Packaging and Labeling Systems, Table-top ... Automation) - Global Forecasts & Trends to 2019” ... and opportunities in North America, Europe, Asia-Pacific, and ... 101 market tables and 30 figures spread through ...
Breaking Biology Technology:Pipette.com Launches the Addition of Sartorius CPA Semi-Micro Balance to Their Product Portfolio with Special Promotional Pricing 2Pipette.com Launches the Addition of Sartorius CPA Semi-Micro Balance to Their Product Portfolio with Special Promotional Pricing 3Cloud Professional Services Market by Public, Private, Hybrid & Community Expected to Reach $34.41 Billion by 2019 - New Report by MarketsandMarkets 2Cloud Professional Services Market by Public, Private, Hybrid & Community Expected to Reach $34.41 Billion by 2019 - New Report by MarketsandMarkets 3Cloud Professional Services Market by Public, Private, Hybrid & Community Expected to Reach $34.41 Billion by 2019 - New Report by MarketsandMarkets 4Cloud Professional Services Market by Public, Private, Hybrid & Community Expected to Reach $34.41 Billion by 2019 - New Report by MarketsandMarkets 5Nuvilex Brief Analyst Report: Thinking Outside the Box by BrokerBank Securities, Inc. 2Pharmacy Automation Systems Market worth $4,566.2 Million by 2019 - New Research Report by MarketsandMarkets 2Pharmacy Automation Systems Market worth $4,566.2 Million by 2019 - New Research Report by MarketsandMarkets 3Pharmacy Automation Systems Market worth $4,566.2 Million by 2019 - New Research Report by MarketsandMarkets 4
... 2011 Netsmart Technologies, Inc., a leading provider ... organizations nationwide, today announced an agreement with the ... for the provision of a comprehensive behavioral health ... be known as the Integrated Behavioral Health Information ...
... 1, 2011 Optimer Pharmaceuticals, Inc. (NASDAQ: ... at the 20th Annual Credit Suisse Healthcare Conference on ... AM Pacific Time). (Logo:   http://photos.prnewswire.com/prnh/20090413/LA97352LOGO ) ... will be accessible on the Investors page of the ...
... 2011 Elsevier, a world-leading provider of ... announced the availability of Elsevier Urban & Fischer ... life and health sciences, on SciVerse ScienceDirect . ... the renowned German imprint Urban & Fischer, contain journals ...
Cached Biology Technology:County of Los Angeles Selects Netsmart to Provide Comprehensive Behavioral Health Information System 2County of Los Angeles Selects Netsmart to Provide Comprehensive Behavioral Health Information System 3Elsevier Announces Availability of Urban & Fischer Journal Archives on SciVerse ScienceDirect 2
...
Recombinant Rat Leptin, CF...
Adhesive seal-tab, for HybriWell™ hybridization sealing system *set of 400*...
... cell culture systems provide an integrated ... staining and imaging. Each system uses ... optical-quality coverslips in cell culture plates. ... and ready to use. Individual chambered ...
Biology Products: