Navigation Links
Mycobacterium tuberculosis: Our African follower for over 70,000 years!
Date:9/1/2013

Tuberculosis (TB) remains one of deadliest infectious diseases of humans, killing 50% of individuals when left untreated. Even today, TB causes 1-2 million deaths every year mainly in developing countries. Multidrug-resistance is a growing threat in the fight against the disease.

An international group of researchers led by Sebastien Gagneux from the Swiss Tropical and Public Health Institute (Swiss TPH) has now identified the origin in time and space of the disease. Using whole-genome sequencing of 259 Mycobacterium tuberculosis strains collected from different parts of the world, they determined the genetic pedigree of the deadly bugs. This genome comparison to be published September 1st in the journal Nature Genetics indicates that TB mycobacteria originated at least 70,000 years ago in Africa.

Stunningly close relationship between humans and M. tuberculosis

The researchers compared the genetic evolutionary trees of mycobacteria and humans side-by-side. And to the researcher's surprise, the phylogenetic trees of humans and the TB bacteria showed a very close match. "The evolutionary path of humans and the TB bacteria shows striking similarities," says Sebastien Gagneux.

This strongly points to a close relationship between the two, lasting tens of thousands of years. Humans and TB bacteria not only have emerged in the same region of the world, but have also migrated out of Africa together and expanded all over the globe.

The migratory behaviour of modern humans accompanied with changes in lifestyle has created favourable conditions for an increasingly deadly disease to evolve. "We see that the diversity of tuberculosis bacteria has increased markedly when human populations expanded," says evolutionary biologist Sebastien Gagneux.

Human expansion in the so called Neolithic Demographic Transition (NDT) period combined with new human lifestyles living in larger groups and in village-like structures may have created conditions for the efficient human-to-human transmission of the disease, Gagneux suggests. This may also have increased the virulence of the bacteria over time.

The results indicate further that TB is unlikely to have jumped from domesticated animals to humans, as seen for other infectious diseases. "Simply, because Mycobacteria tuberculosis emerged long before humans started to domesticate animals," says Swiss TPH's Sebastien Gagneux.

New strategies to defeat tuberculosis

Tuberculosis remains a global threat. New drugs and vaccines are urgently needed to fight this poverty-related disease. Multidrug-resistance against first-line treatments is a growing threat in many countries. Therefore, the exploration of the evolutionary patterns of TB bacteria may help predicting future patterns of the disease. This may contribute to future drug discovery and to the design of improved strategies for disease control.


'/>"/>

Contact: Christian Heuss
christian.heuss@unibas.ch
41-612-848-683
Swiss Tropical and Public Health Institute
Source:Eurekalert

Related biology news :

1. UNH researchers find African farmers need better climate change data to improve farming practices
2. Treatment to benefit African infants at risk of endemic fever
3. African scientist, designer partner to fashion anti-malaria garment that wards off bugs
4. Herbivores select on floral architecture in a South African bird-pollinated plant
5. South African daffodils may be a future cure for depression
6. Levels of hepatitis C virus higher among African-Americans and males
7. African research identifies strong candidate for possible single-dose malaria cure
8. African Americans less likely to adhere to DASH diet for lowering blood pressure
9. Report: Bushmeat pushes Southern African species to the brink
10. RTS,S malaria candidate vaccine reduces malaria by approximately one-third in African infants
11. Raising the african voice on climate change
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/30/2017)... June 30, 2017 Today, American Trucking ... supplier of face and eye tracking software, became ... provider program. "Artificial intelligence and ... to monitor a driver,s attentiveness levels while on ... able to detect fatigue and prevent potential accidents, ...
(Date:6/14/2017)... (NYSE: IBM ) is introducing several innovative partner startups ... collaboration between startups and global businesses, taking place in ... nine startups will showcase the solutions they have built with ... France is one of the ... percent increase in the number of startups created between 2012 ...
(Date:5/16/2017)... N.J. , May 16, 2017  Veratad Technologies, ... provider of online age and identity verification solutions, announced ... K(NO)W Identity Conference 2017, May 15 thru May 17, ... Regan Building and International Trade Center. ... the globe and in today,s quickly evolving digital world, ...
Breaking Biology News(10 mins):
(Date:8/23/2017)... ... August 23, 2017 , ... ... and academic medical centers. The network provides members nationally scaled infrastructure and support ... biologics and restrictive payer agreements so members can provide continuity of care for ...
(Date:8/22/2017)... ... August 22, 2017 , ... One of ... the practice of opioid-dose sparing. Opioid-dose sparing refers to the reduction of opioid ... with non-steroidal anti-inflammatory drugs (NSAIDs). , The potential for new therapies to replace ...
(Date:8/21/2017)... (PRWEB) , ... August 20, 2017 , ... ... Journal of Biomedical Optics (JBO) starting 1 January 2018. The journal is published ... Biomedical Optics publishes papers on the use of modern optical technology for improved ...
(Date:8/21/2017)... ... August 21, 2017 , ... Finalists have recently ... medical centers that have implemented innovative products, services, and technology over the past ... advantages, financial impact/value, and market need. The applicants with the top three scores ...
Breaking Biology Technology: