Date:12/6/2012

rents. These 6 billion DNA letters belong to hundreds of microbes, each with thousands of different strains: mapping each DNA fragment of the metagenome to its right place, in the right bacterial genome, is extremely complex. To achieve this breakthrough and carry the analysis down to the single DNA letter, scientists had to develop various new computational methods. In the current study more than 10 million mutations have been detected in the 207 individuals.

All these detailed data is now stored in public databases, such as dbSNP, freely available to the scientific community. These findings could lead to the development of new approaches in the identification of gut diseases, pathogens, or antibiotic resistance. On the longer term, they may also open new avenues for personalised therapies.

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Contact: Isabelle Kling isabelle.kling@embl.de 49-622-138-78355 European Molecular Biology Laboratory Source:Eurekalert

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