Navigation Links
My microbes
Date:12/6/2012

We all have E.coli bacteria in our gut but each of us carries a version that is genetically slightly different. The same can be said of most gut microbes: our own gut metagenome, that is the sum of all the genomes of all our gut microbes, appears to be really specific to each of us, and to remain stable over time. For the first time, researchers from the European Molecular Biology Laboratory (EMBL) have studied this metagenome at such a high resolution that individual mutations in the various strains could be analysed. Their findings, published today in Nature, could have widespread consequences in medicine: gut microbes are known to be essential for functions as vital as digesting food or providing vitamins, but can also be involved in diseases if they carry certain mutations.

The scientists analysed the gut metagenome of 207 individuals from Europe and the USA, matching more than 7 billion pieces of DNA (of 100 lettres each) to the genomes of our most abundant gut microbial species. "This large scale analysis showed that, at least when healthy, we carry a unique set of bacterial strains and their mutations in our gut, over a long time," explains Peer Bork who led the study at EMBL. "It is like a second genetic signature, but one that probably does not come from our parents but that we acquire from the environment in early childhood."

When comparing the specific mutations from the same individual over time, the researchers found that the metagenome remains stable for at least one year, and probably much longer when the individuals are healthy. Results also show that there is only little geographic difference when comparing metagenomes of European with North-American individuals. This indicates that gradual adaptation is possible.

For each individual, approximately 6 billion DNA letters of their gut metagenome have been analysed, many more than the 3.3 billion DNA letters of human DNA that we inherit from each of our parents. These 6 billion DNA letters belong to hundreds of microbes, each with thousands of different strains: mapping each DNA fragment of the metagenome to its right place, in the right bacterial genome, is extremely complex. To achieve this breakthrough and carry the analysis down to the single DNA letter, scientists had to develop various new computational methods. In the current study more than 10 million mutations have been detected in the 207 individuals.

All these detailed data is now stored in public databases, such as dbSNP, freely available to the scientific community. These findings could lead to the development of new approaches in the identification of gut diseases, pathogens, or antibiotic resistance. On the longer term, they may also open new avenues for personalised therapies.


'/>"/>
Contact: Isabelle Kling
isabelle.kling@embl.de
49-622-138-78355
European Molecular Biology Laboratory
Source:Eurekalert

Related biology news :

1. Ancient microbes found living beneath the icy surface of Antarctic lake
2. UIC scientists find ancient microbes in salty, ice-sealed Antarctic lake
3. Microbes help hyenas communicate via scent
4. Microbes, sponges, and worms add to coral reef woes
5. Roots and microbes: Bringing a complex underground ecology into the lab
6. Microbes make clean methane
7. Stanford-Penn State scientists use microbes to make clean methane
8. MBL scientists to explore hidden realm of microbes, viruses beneath the ocean floor
9. Gut microbes battle a common set of viruses shared by global populations
10. Waves of Berkeley Lab responders deploy omics to track Deepwater Horizon cleanup microbes
11. AGU: Unique microbes found in extreme environment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/7/2016)... According to a new market research report "Emotion Detection ... Voice Recognition), Service, Application Area, End User, And Region - Global Forecast to ... 6.72 Billion in 2016 to USD 36.07 Billion by 2021, at a Compound ... ... MarketsandMarkets Logo ...
(Date:12/7/2016)... --  Avanade is helping Williams Martini Racing, one ... exploit biometric data in order to critically analyse every ... edge against their rivals after their impressive, record-breaking pit ... worked with Williams during the 2016 season to capture ... breathing rate, temperature and peak acceleration) for key members ...
(Date:12/6/2016)... 2016  Zimmer Biomet Holdings, Inc. (NYSE and SIX: ZBH) ... of €500.0 million principal amount of its 1.414% senior unsecured ... 2.425% senior unsecured notes due 2026. The ... 2016, subject to the satisfaction of customary closing conditions.  The ... The Company intends to use the net ...
Breaking Biology News(10 mins):
(Date:12/7/2016)... 7, 2016 /PRNewswire/ - Zenith Capital Corp. ("Zenith" or the "Company") ... presented at the Company,s Annual and Special Meeting. ... take place on Thursday, December 15, 2016 at ... (Room EC1040), 4825 Mount Royal Gate SW, Calgary, ... of meeting and management information circular, containing the matters to ...
(Date:12/7/2016)... Dec. 7, 2016  Biocom, the association for the ... below following passage of 21 st Century Cures legislation ... 30 by a 392-26 vote and in the Senate on ... attributed to Joe Panetta , president & CEO of ... give hope to millions of patients around the world. The ...
(Date:12/7/2016)... Minn. , Dec. 7, 2016  Vyriad Inc. ... to the company,s Board of Directors. ... as we build our business and develop our oncolytic ... cancer therapy," said Stephen Russell , MD, PhD, ... Agnes , share our vision and passion for making ...
(Date:12/7/2016)...  Muse bio, a privately-held company leading the development ... Kevin Ness has been appointed Chief Executive ... Kevin succeeds Muse bio,s founding CEO ... Officer as well as remains Slade Professor, Chemical and ... at the RAS Energy Institute at the University of ...
Breaking Biology Technology: