Navigation Links
My microbes
Date:12/6/2012

We all have E.coli bacteria in our gut but each of us carries a version that is genetically slightly different. The same can be said of most gut microbes: our own gut metagenome, that is the sum of all the genomes of all our gut microbes, appears to be really specific to each of us, and to remain stable over time. For the first time, researchers from the European Molecular Biology Laboratory (EMBL) have studied this metagenome at such a high resolution that individual mutations in the various strains could be analysed. Their findings, published today in Nature, could have widespread consequences in medicine: gut microbes are known to be essential for functions as vital as digesting food or providing vitamins, but can also be involved in diseases if they carry certain mutations.

The scientists analysed the gut metagenome of 207 individuals from Europe and the USA, matching more than 7 billion pieces of DNA (of 100 lettres each) to the genomes of our most abundant gut microbial species. "This large scale analysis showed that, at least when healthy, we carry a unique set of bacterial strains and their mutations in our gut, over a long time," explains Peer Bork who led the study at EMBL. "It is like a second genetic signature, but one that probably does not come from our parents but that we acquire from the environment in early childhood."

When comparing the specific mutations from the same individual over time, the researchers found that the metagenome remains stable for at least one year, and probably much longer when the individuals are healthy. Results also show that there is only little geographic difference when comparing metagenomes of European with North-American individuals. This indicates that gradual adaptation is possible.

For each individual, approximately 6 billion DNA letters of their gut metagenome have been analysed, many more than the 3.3 billion DNA letters of human DNA that we inherit from each of our parents. These 6 billion DNA letters belong to hundreds of microbes, each with thousands of different strains: mapping each DNA fragment of the metagenome to its right place, in the right bacterial genome, is extremely complex. To achieve this breakthrough and carry the analysis down to the single DNA letter, scientists had to develop various new computational methods. In the current study more than 10 million mutations have been detected in the 207 individuals.

All these detailed data is now stored in public databases, such as dbSNP, freely available to the scientific community. These findings could lead to the development of new approaches in the identification of gut diseases, pathogens, or antibiotic resistance. On the longer term, they may also open new avenues for personalised therapies.


'/>"/>
Contact: Isabelle Kling
isabelle.kling@embl.de
49-622-138-78355
European Molecular Biology Laboratory
Source:Eurekalert

Related biology news :

1. Ancient microbes found living beneath the icy surface of Antarctic lake
2. UIC scientists find ancient microbes in salty, ice-sealed Antarctic lake
3. Microbes help hyenas communicate via scent
4. Microbes, sponges, and worms add to coral reef woes
5. Roots and microbes: Bringing a complex underground ecology into the lab
6. Microbes make clean methane
7. Stanford-Penn State scientists use microbes to make clean methane
8. MBL scientists to explore hidden realm of microbes, viruses beneath the ocean floor
9. Gut microbes battle a common set of viruses shared by global populations
10. Waves of Berkeley Lab responders deploy omics to track Deepwater Horizon cleanup microbes
11. AGU: Unique microbes found in extreme environment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/6/2017)... Forecasts by Product Type (EAC), ... End-Use (Transportation & Logistics, Government & Public Sector, Utilities ... Generation Facility, Nuclear Power), Industrial, Retail, Business Organisation (BFSI), ... you looking for a definitive report on the $27.9bn ... ...
(Date:4/3/2017)... 2017  Data captured by IsoCode, IsoPlexis ... a statistically significant association between the potency ... and objective response of cancer patients post-treatment. ... whether cancer patients will respond to CAR-T ... as to improve both pre-infusion potency testing and ...
(Date:3/28/2017)... 28, 2017 The report "Video ... Monitors, Servers, Storage Devices), Software (Video Analytics, VMS), and ... Global Forecast to 2022", published by MarketsandMarkets, the market ... is projected to reach USD 75.64 Billion by 2022, ... The base year considered for the study is 2016 ...
Breaking Biology News(10 mins):
(Date:8/16/2017)... ... August 16, 2017 , ... ... Food and Drug Administration (FDA) inspection at our Dilworth, MN site. The inspection ... issued. This inspection was conducted as part of a routine Bioresearch Monitoring Program ...
(Date:8/15/2017)... After spending the past two years building a state-of-the-art technology which ... offers this platform to healthcare stakeholders (hospitals, foundations, biopharma companies etc.) ... collection vis a vis their members, under their own brand. Three ... offer. ... ...
(Date:8/15/2017)... ... August 15, 2017 , ... Pittcon is ... for analytical and scientific instruments. This year’s symposium, organized by the Pittcon 2018 ... Spectrometry for Bioanalytical Applications.” This dynamic presentation will discuss novel ionization processes, high ...
(Date:8/15/2017)... ... August 15, 2017 , ... The Conference Forum ... 360° (IO360°) programming through a series of upcoming panels and events. The partnership culminates ... at The Roosevelt Hotel in New York City. , “With our experience in producing ...
Breaking Biology Technology: