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Mutations in different cells cooperate to set the stage for cancer
Date:1/13/2010

to tumorigenesis.

Intriguingly, the JNK activity seems to spread from scrib- cells via a mysterious, domino-type effect. "The signal is relayed from cell to cell," Xu said. "So if we stop it in one cell, then the signal no longer propagates."

Xu and his colleagues say that the scrib- mutation is not the only thing that can spur JNK signaling. JNK is a stress-response signal, which is activated when tissues are wounded or inflamed, and it appears to be necessary for wound healing. Thus relatively ordinary stress, in concert with a RasV12 mutation, might be enough to trigger cancer.

"It has been suspected that stress contributes to cancer because individuals that are frequently exposed to stressed conditions such as inflammation are more likely to develop cancer," said Xu. "We have learned that indeed stress can help tumor development and it does so by activating the JNK stress signaling process. Now we know this, we can consider targeting it with therapeutics."


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Contact: Jennifer Michalowski
michalow@hhmi.org
301-215-8576
Howard Hughes Medical Institute
Source:Eurekalert

Page: 1 2 3

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