Navigation Links
Mutations can spur dangerous identity crisis in cells
Date:7/1/2011

As our bodies first form, developing cells are a lot like children put on the school bus with their names and addresses pinned to their shirts.

The notes identify one as a future heart cell, another as a liver cell, a third as a neuron. And that's what they each grow up to be.

But once those cells reach adulthood, changes to those original marching orders caused by aging, disease and other stressors like smoking can precipitate a kind of identity crisis, researchers at the University of Michigan Health System have found.

The cells start to forget things like which genes are supposed to be turned on and which turned off. This can lead to significant changes in their ability to function.

While microscopic, these changes can still have profound impacts on living beings. When this type of mutation was purposefully introduced into the heart muscle cells of mice, the normal functioning of the heart's electrical systems were disturbed, at times leading to dangerous arrhythmia, a new U-M study shows.

The results, published in the July issue of the Journal of Clinical Investigation, bring us one step closer to developing treatments for issues associated with aging or chronic diseases in which cells lose their ability to maintain a stable pattern of gene expression, says senior study author Gregory R. Dressler, Ph.D., collegiate professor of pathology research at the U-M Medical School.

"We're excited about this research because it suggests that these mutations can be the cause of disease as well as the result," says lead author Adam B. Stein, M.D., an assistant professor of cardiology at U-M.

Stein, Dressler and their colleagues are working in a relatively new area of research known as "epigenetics." It's well known that human beings pass a life code, bound up in the double helix of our DNA, from one generation to the next. What's less well understood is that they also transmit sets of instructions
'/>"/>

Contact: Ian Demsky
idemsky@umich.edu
734-764-2220
University of Michigan Health System
Source:Eurekalert

Page: 1 2

Related biology news :

1. Evolutionary kings of the hill use good, bad and ugly mutations to speed ahead of competition
2. Scientists develop method to determine order of mutations that lead to cancer
3. Women with BRCA mutations can take hormone-replacement therapy safely after ovary removal
4. UMMS researchers develop new technology to screen and analyze genetic mutations
5. Researchers link gene mutations to Ebsteins anomaly
6. Drug may treat cystic fibrosis, other diseases caused by nonsense mutations, UAB researcher says
7. Scripps Research scientists reveal how genetic mutations may cause type 1 diabetes
8. Supplement blocks the initiation of breast cell mutations by estrogens
9. Penn biologists explain how organisms can tolerate mutations, yet adapt to environmental change
10. Mutations in different cells cooperate to set the stage for cancer
11. Study of huge numbers of genetic mutations point to oxidative stress as underlying cause
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/7/2014)... Leading Biometric companies aim to provide ... online transactions.  Companies in focus today are: NXT-ID, Inc. (NASDAQ: ... BABA ), Google Inc. (NASDAQ: GOOG ), Microsoft ... EBAY ) and MasterCard Inc. (NYSE: MA) ... biometric authentication company focused on the growing mobile commerce is ...
(Date:11/6/2014)... Baltimore, MD, November 6, 2014 - Insilico Medicine, ... in aging and age related diseases announced a ... medicine of cancer, Champions Oncology, Inc (OTC: CSBR). ... genomics for personalized medicine, but Champions Oncology,s TumorGraft ... can validate the chemotherapy regimen experimentally generating vast ...
(Date:11/4/2014)... 2014 – University of Utah engineers developed the first ... fuel produce electricity without needing to ignite the fuel. ... portable electronics, off-grid power and sensors. , A study ... American Chemical Society journal ACS Catalysis . , ... reaction between a fuel and an oxygen-rich source such ...
Breaking Biology News(10 mins):Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 2Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 3Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 4Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 5Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 6Insilico Medicine, Inc announces research collaboration with Champions Oncology, Inc 2Jet-fueled electricity at room temperature 2
... University of York's Department of Chemistry have developed a ... unpleasant and dangerous side-effects of radiotherapy. , PhD students ... fellow Mark Godber, have developed the gel which will ... Now, the group has secured £30,000 under the Bioscience ...
... oil, which have antioxidant, anti-inflammatory and anti-clotting properties, ... so-called Mediterranean Diet, according to a new study ... Journal of the American College of Cardiology. , ... the Mediterranean diet on cardiovascular disease and arteriosclerosis ...
... California condors raised in captivity be released near seal and ... feast on the carcasses of marine mammals as their ancestors ... four other institutions base their conclusion on the feeding behavior ... in the Nov. 7 online edition of the Proceedings of ...
Cached Biology News:Young scientists turn to gel to ease side-effects of cancer treatment 2Phenolic compounds may explain Mediterranean diet benefits 2Phenolic compounds may explain Mediterranean diet benefits 3Seal rookeries could provide a reliable food source for endangered California condors, study finds 2Seal rookeries could provide a reliable food source for endangered California condors, study finds 3Seal rookeries could provide a reliable food source for endangered California condors, study finds 4Seal rookeries could provide a reliable food source for endangered California condors, study finds 5
(Date:11/21/2014)... USA (PRWEB) November 19, 2014 The ... our lives was shared with more than 200 primary ... postgraduate students from the University of Otago Physics Department ... . The Otago students, members of the university’s OSA/SPIE ... Zealand in early September, giving children from small, rural ...
(Date:11/21/2014)... The California Healthcare Institute ... representing leading California academic institutions, biotechnology, medical device, ... today released a report revealing that California ... The trend shows a 4 percent increase between ... Industry Report indicates that, while biopharmaceutical and ...
(Date:11/21/2014)... Arkansas (PRWEB) November 20, 2014 ... Pinnacle Ozone Solutions, LLC (Pinnacle), and PCI, Inc., ... announced that they have been selected to provide ... of Fayetteville, Arkansas Paul R. Noland Wastewater Treatment. ... BlueInGreen’s patented HyDOZ® gas dissolution technology, ...
(Date:11/21/2014)... 21, 2014 2014 Deep Research ... and in-depth research report on the transformer market. ... classification, application, and industry chain structure as well ... market analysis, including China’s domestic market as well ... economic situation analysis. The report also covers information ...
Breaking Biology Technology:Optics and photonics outreach programs share science, spark fascination with light 2Optics and photonics outreach programs share science, spark fascination with light 3California Healthcare Institute and PwC Report Boom in California’s Biomedical Industry 2California Healthcare Institute and PwC Report Boom in California’s Biomedical Industry 3California Healthcare Institute and PwC Report Boom in California’s Biomedical Industry 4City of Fayetteville Leads Nation with Innovative Ozone Technology 2City of Fayetteville Leads Nation with Innovative Ozone Technology 3City of Fayetteville Leads Nation with Innovative Ozone Technology 4International Transformer Industry - Analysis on Applications, Development & Forecasts Now Available at ReportsnReports.com 2International Transformer Industry - Analysis on Applications, Development & Forecasts Now Available at ReportsnReports.com 3
... May 12 Aton Pharma, Inc., a global,specialty ... a,distribution agreement with Meizler Biopharma S/A to commercialize,CUPRIMINE(R) ... in,Brazil, and Meizler is working to obtain regulatory ... medically essential products, and Aton is,committed to making ...
... Poised to Impact Lung Cancer Care, ST. ... medical,device start-up company, has secured $4.75M in venture ... IG4 delivery system for minimally,invasive biopsy and ablation ... and was joined by Advantage Capital Partners and ...
... (NYSE:,CVD) today announced that it will present at the ... 2008 at 10:30 am ET. Investors may,access a live ... order to,register and download any necessary software, please log ... New Jersey, is one of the,world,s largest and most ...
Cached Biology Technology:Aton Pharma Announces Distribution Partnership in Brazil 2Veran Medical Technologies Secures $4.75M in First Institutional Funding 2
... ProteinChip Antibody Capture Kit ... and optimization steps typically ... interactions. This kit enables ... of multiple antigens based ...
... Custom design, The Bioactive peptides are molecules ... a biological behaviour or activity which can ... pharmaceutical, diagnostic, chemical and agro-food applications. In ... modified peptides with superior properties for therapeutic ...
... This CLS number is ... to easily match Cornings product ... yet, please order under the ... contact customer service for assistance. ...
... Series Hybridization chambers with forced convection ... ambient up to 99.9 C / 212 F ... and reproducible results DS controller Timer ... with an accuracy of a tenth of a ...
Biology Products: