Navigation Links
Mutations can spur dangerous identity crisis in cells
Date:7/1/2011

As our bodies first form, developing cells are a lot like children put on the school bus with their names and addresses pinned to their shirts.

The notes identify one as a future heart cell, another as a liver cell, a third as a neuron. And that's what they each grow up to be.

But once those cells reach adulthood, changes to those original marching orders caused by aging, disease and other stressors like smoking can precipitate a kind of identity crisis, researchers at the University of Michigan Health System have found.

The cells start to forget things like which genes are supposed to be turned on and which turned off. This can lead to significant changes in their ability to function.

While microscopic, these changes can still have profound impacts on living beings. When this type of mutation was purposefully introduced into the heart muscle cells of mice, the normal functioning of the heart's electrical systems were disturbed, at times leading to dangerous arrhythmia, a new U-M study shows.

The results, published in the July issue of the Journal of Clinical Investigation, bring us one step closer to developing treatments for issues associated with aging or chronic diseases in which cells lose their ability to maintain a stable pattern of gene expression, says senior study author Gregory R. Dressler, Ph.D., collegiate professor of pathology research at the U-M Medical School.

"We're excited about this research because it suggests that these mutations can be the cause of disease as well as the result," says lead author Adam B. Stein, M.D., an assistant professor of cardiology at U-M.

Stein, Dressler and their colleagues are working in a relatively new area of research known as "epigenetics." It's well known that human beings pass a life code, bound up in the double helix of our DNA, from one generation to the next. What's less well understood is that they also transmit sets of instructions
'/>"/>

Contact: Ian Demsky
idemsky@umich.edu
734-764-2220
University of Michigan Health System
Source:Eurekalert

Page: 1 2

Related biology news :

1. Evolutionary kings of the hill use good, bad and ugly mutations to speed ahead of competition
2. Scientists develop method to determine order of mutations that lead to cancer
3. Women with BRCA mutations can take hormone-replacement therapy safely after ovary removal
4. UMMS researchers develop new technology to screen and analyze genetic mutations
5. Researchers link gene mutations to Ebsteins anomaly
6. Drug may treat cystic fibrosis, other diseases caused by nonsense mutations, UAB researcher says
7. Scripps Research scientists reveal how genetic mutations may cause type 1 diabetes
8. Supplement blocks the initiation of breast cell mutations by estrogens
9. Penn biologists explain how organisms can tolerate mutations, yet adapt to environmental change
10. Mutations in different cells cooperate to set the stage for cancer
11. Study of huge numbers of genetic mutations point to oxidative stress as underlying cause
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2015)... ( http://www.researchandmarkets.com/research/kvdtcw/face_and_voice ) has announced the addition of the ... report to their offering. This report analyzes the worldwide ... following Segments: Face Biometrics, and Voice Biometrics. The report provides separate ... Japan , Europe , ... Africa , and Latin America . ...
(Date:3/23/2015)... NEW YORK , March 23, 2015   ... digital property management company, today announced that the Company ... platform for both enterprise and consumers at Connect:ID on ... D.C. HOYOS Labs will highlight the IEEE ... 1U TM ; and enterprise access control system. ...
(Date:3/20/2015)... 19, 2015 Research and Markets ( http://www.researchandmarkets.com/research/rswjb4/hand_geometry ... - Global Strategic Business Report" report to their offering. ... Geometry in US$ Thousands. The report provides separate comprehensive analytics ... Japan , Europe , ... Rest of World. Annual estimates and forecasts are ...
Breaking Biology News(10 mins):Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 2Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 3Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 4Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 5Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 6HOYOS Labs to Showcase Host of Biometrics Technologies at Connect:ID in Washington, D.C. 2HOYOS Labs to Showcase Host of Biometrics Technologies at Connect:ID in Washington, D.C. 3Hand Geometry - Global Strategic Business Report 2015: An Essential Security Component for both Government & Enterprise Sector 2Hand Geometry - Global Strategic Business Report 2015: An Essential Security Component for both Government & Enterprise Sector 3Hand Geometry - Global Strategic Business Report 2015: An Essential Security Component for both Government & Enterprise Sector 4
... of Agriculture passed a series of regulations designed to ... to increase whole grain offerings and making students select ... However, children cannot be forced to eat these healthier ... The Journal of Pediatrics , researchers determined ...
... 26, 2013  The March 2013 issue of The Journal ... Association, includes a study conducted by four physicians from Radiotherapy ... Oncology affiliate.  This study, 25 Year Disease Free Survival ... Specific Antigen Definition of Recurrence Used for Radical Prostatectomy, ...
... February 26, 2013, New York, N.Y. and San Diego, Calif. ... tumor in adults, is challenging to treat because the tumors ... more about the causes of tumor cell growth and drug ... new targeted therapies to potentially treat this deadly cancer. ...
Cached Biology News:Libertarian paternalism and school lunches: Guiding healthier behavior while preserving choices 2Georgia Physicians' Study Published in The Journal of Urology 2Georgia Physicians' Study Published in The Journal of Urology 3Georgia Physicians' Study Published in The Journal of Urology 4Novel combination therapy shuts down escape route, killing glioblastoma tumor cells 2
(Date:3/27/2015)... Earlier this year, the Capillus272Pro™ received FDA ... adult men and women with androgenic alopecia (AGA) having ... IIa-V and Fitzpatrick Classification of Skin phototypes I-IV. ... and under-deliver, FDA Clearance underscores the safety and efficacy ... than 80 million men and women who suffer with ...
(Date:3/27/2015)...  Neogen Corporation (NASDAQ: NEOG ) announced today ... plan in accordance with Securities and Exchange Commission rule ... Neogen Corporation, is a minority owner of this entity ... Herbert does not have control of this entity, ... only for a portion of the shares owned by ...
(Date:3/27/2015)... -- Working in collaboration with the National Amyloidosis ... , Richmond Pharmacology is the first centre worldwide to ... an investigational RNAi therapeutic being developed for the treatment of ... heart. Read press release ... St Georges University of London , Richmond ...
(Date:3/27/2015)... 2015 Governor Andrew M. Cuomo today ... 43North - the world’s largest business idea competition with ... of $1 million, six $500,000 awards and four $250,000 ... to compete for prizes that will turn ideas with ... New York region. , "Last year's successful 43North ...
Breaking Biology Technology:Dr. Robert Leonard Applauds FDA Clearance of Capillus272Pro™ Hair Loss Laser Cap 2Neogen CEO adopts 10b5-1 Trading Plan 2Governor Andrew M. Cuomo Anounces Launch of Year Two of World's Largest Business Idea Competition and Opening of New Incubator Space in Buffalo, New York 2Governor Andrew M. Cuomo Anounces Launch of Year Two of World's Largest Business Idea Competition and Opening of New Incubator Space in Buffalo, New York 3Governor Andrew M. Cuomo Anounces Launch of Year Two of World's Largest Business Idea Competition and Opening of New Incubator Space in Buffalo, New York 4Governor Andrew M. Cuomo Anounces Launch of Year Two of World's Largest Business Idea Competition and Opening of New Incubator Space in Buffalo, New York 5
... during the first quarter of 2005 amid poor overall stock ... at the larger cap life science companies. Note that these ... You may have noticed headlines at the end of last ... Cox-2 inhibitor (Bextra) off the market. , ,This stronger-than-expected action ...
... Critics of the state's plan to replace its decade-old video ... that a contract with an SBC-headed alliance had already been ... companies including SBC, Verizon, Norlight, CenturyTel and local telcos, has ... estimated cost of $116 million and operate it for five ...
... to rewrite the entire statute that governs how ... said Kathleen Abernathy, an FCC Commissioner and graduate ... executives gathered at the Eighth Annual Midwestern Telecommunications ... world where broadband is king, a world where ...
Cached Biology Technology:Midwest large-cap life-science sector is solid in first quarter 2State criticized over BadgerNet 2 execution; some doubt benefits 2State criticized over BadgerNet 2 execution; some doubt benefits 3FCC may restructure to tackle broadband regulation 2
...
...
... cytostatic and anti-viral agent. Inhibits several important steps ... formation of HUVEC cells. Also reduces intracellular reactive ... IL-8 release of endothelial cells. ... 16 O 8 MolWeight: ...
See product name for description....
Biology Products: