Navigation Links
Mutations can spur dangerous identity crisis in cells

As our bodies first form, developing cells are a lot like children put on the school bus with their names and addresses pinned to their shirts.

The notes identify one as a future heart cell, another as a liver cell, a third as a neuron. And that's what they each grow up to be.

But once those cells reach adulthood, changes to those original marching orders caused by aging, disease and other stressors like smoking can precipitate a kind of identity crisis, researchers at the University of Michigan Health System have found.

The cells start to forget things like which genes are supposed to be turned on and which turned off. This can lead to significant changes in their ability to function.

While microscopic, these changes can still have profound impacts on living beings. When this type of mutation was purposefully introduced into the heart muscle cells of mice, the normal functioning of the heart's electrical systems were disturbed, at times leading to dangerous arrhythmia, a new U-M study shows.

The results, published in the July issue of the Journal of Clinical Investigation, bring us one step closer to developing treatments for issues associated with aging or chronic diseases in which cells lose their ability to maintain a stable pattern of gene expression, says senior study author Gregory R. Dressler, Ph.D., collegiate professor of pathology research at the U-M Medical School.

"We're excited about this research because it suggests that these mutations can be the cause of disease as well as the result," says lead author Adam B. Stein, M.D., an assistant professor of cardiology at U-M.

Stein, Dressler and their colleagues are working in a relatively new area of research known as "epigenetics." It's well known that human beings pass a life code, bound up in the double helix of our DNA, from one generation to the next. What's less well understood is that they also transmit sets of instructions written in proteins and enzymes that tell each cell of the body which genes should be expressed, that is, which should be turned on and which turned off, Dressler says. (Epigenetic means, basically, a trait that is inherited but not encoded directly in the DNA.)

Early on, when all the cells in an embryo are an undifferentiated mass of stem cells, these instructions lay out the master plan. Like children groomed for the Olympic greatness, their destinies are spelled out for them: nerve, muscle, bone.

"What scientists didn't know was whether those instructions, once in place, must be maintained after a cell reaches maturity," Dressler explains. "We wanted to find out what happens when you remove some of the imprinting machinery that tells the heart cell that it's a heart cell."

The researchers found that those instructions matter quite a bit.

"What we found was that it's important for the body to keep telling the heart cell, 'You're a heart cell, you're a heart cell,' " says Dressler, who notes the research was the first time this mechanism has been studied in a living mammal. "When you knock out a piece of those instructions, the heart cell starts to forget who it is. These changes start off small, but over time they can have big effects on the organism."

Moreover, although they can be caused by environmental factors, negative changes like those that led to arrhythmia in the mice could potentially be passed down through the generations.

"The idea that cell state is a stable phenomenon is what's being challenged here," says Dressler. "We believe these findings could eventually lead to drug treatments to fight this type of cell destabilization."


Contact: Ian Demsky
University of Michigan Health System

Related biology news :

1. Evolutionary kings of the hill use good, bad and ugly mutations to speed ahead of competition
2. Scientists develop method to determine order of mutations that lead to cancer
3. Women with BRCA mutations can take hormone-replacement therapy safely after ovary removal
4. UMMS researchers develop new technology to screen and analyze genetic mutations
5. Researchers link gene mutations to Ebsteins anomaly
6. Drug may treat cystic fibrosis, other diseases caused by nonsense mutations, UAB researcher says
7. Scripps Research scientists reveal how genetic mutations may cause type 1 diabetes
8. Supplement blocks the initiation of breast cell mutations by estrogens
9. Penn biologists explain how organisms can tolerate mutations, yet adapt to environmental change
10. Mutations in different cells cooperate to set the stage for cancer
11. Study of huge numbers of genetic mutations point to oxidative stress as underlying cause
Post Your Comments:
(Date:10/29/2015)... 29, 2015 Today, LifeBEAM , ... with 2XU, a global leader in technical performance ... hat with advanced bio-sensing technology. The hat will ... monitor key biometrics to improve overall training performance. ... two companies will bring together the most advanced technology, ...
(Date:10/27/2015)... -- Munich, Germany , October ... automatically maps data from mobile eye tracking videos created ... that they can be quantitatively analyzed with SMI,s analysis ... , October 28-29, 2015. SMI,s Automated Semantic Gaze ... tracking videos created with SMI,s Eye Tracking Glasses ...
(Date:10/26/2015)... India , October 26, 2015 ... --> adds ... 2015 to 2021 as well as ... 2015-2019 research reports to its collection ... . --> ...
Breaking Biology News(10 mins):
(Date:11/24/2015)... ... November 24, 2015 , ... This fall, global software solutions ... in five states to develop and pitch their BIG ideas to improve health and ... are competing for votes to win the title of SAP's Teen Innovator, an all-expenses ...
(Date:11/24/2015)... 2015 --> ... released by Transparency Market Research, the global non-invasive prenatal ... of 17.5% during the period between 2014 and 2022. ... Industry Analysis, Size, Volume, Share, Growth, Trends and Forecast ... market to reach a valuation of US$2.38 bn by ...
(Date:11/24/2015)... Nov. 24, 2015  Twist Bioscience, a company ... Leproust, Ph.D., Twist Bioscience chief executive officer, will ... on December 1, 2015 at 3:10 p.m. Eastern ... City. --> --> ... Twist Bioscience is on Twitter. Sign up to ...
(Date:11/24/2015)... ... November 24, 2015 , ... Creation Technologies ... being named to Deloitte's 2015 Technology Fast 500 list of the fastest growing ... a FDA-cleared, Class II medical device that speeds up orthodontic tooth movement by ...
Breaking Biology Technology: