Navigation Links
Mutation of the COX2 gene can double or treble a woman's risk of ovarian cancer
Date:9/25/2007

Barcelona, Spain: Researchers in Portugal have discovered that a specific mutation of the COX2 gene seems to play a role in the onset of ovarian cancer, increasing womens susceptibility to developing the disease.

The discovery raises the possibility that, if the findings are confirmed by further studies, it might be possible to use non-steroidal anti-inflammatory drugs (NSAIDs), such as aspirin and ibuprofen, which are used already for other conditions, to prevent ovarian cancer developing in women with the COX2 mutation.

Dr Ana Carina Pereira told the European Cancer Conference (ECCO 14) in Barcelona, today (Tuesday) that the COX2 gene is responsible for the production of the enzyme COX-2, which plays a crucial role in prostaglandins production; prostaglandins cause inflammation, pain and fever, as well as mediating a wide range of other physiological processes. Although the causes of ovarian cancer are not fully understood yet, inflammation is known to play an important role in the onset of both ovarian and invasive cervical cancer, she said. COX-2 has an important role in the inflammatory process, as well as in key steps in tumour development.

Dr Pereira, who is a junior scientist in the molecular oncology group at the Portuguese Institute of Oncology, Oporto, Portugal, said that one mutation, the -765G>C COX2 polymorphism, had been associated with the development of a number of diseases such as cancers of the stomach, oesophagus and prostate, and asthma, heart attacks and stroke. So she and her colleagues decided to investigate the role it played in ovarian and invasive cervical cancer.

They analysed the DNA in blood samples from 727 women; 150 had ovarian cancer, 351 had cervical lesions, including 291 with cervical cancer, and the remaining 226 women had no cancer and were the control group.

Although they found no evidence that the -765G>C COX2 polymorphism played a role in cervical cancer, they found that par
'/>"/>

Contact: Emma Mason
wordmason@mac.com
34-932-308-834
ECCO-the European CanCer Conference
Source:Eurekalert

0

GOOD

Page: 1 2 3

Related biology news :

1. Novel technology detects human DNA mutations
2. Fox Chase Cancer Center scientists identify immune-system mutation
3. Mitochondrial DNA mutations play significant role in prostate cancer
4. Same mutation aided evolution in many fish species, Stanford study finds
5. Bioelectronic ‘signatures?hold key to DNA mutations
6. Sugar beet virus mutation requires Texas touch
7. Mutation in clams protects against paralytic shellfish poisoning but raises human health risk
8. Multi-species genome comparison sheds new light on evolutionary processes, cancer mutations
9. Newly recognized gene mutation may reduce seeds, resurrect plants
10. High-throughput oncogene mutation detection in human cancers by mass spectrometry-based genotyping
11. Treatments have same target, different responses for lung cancer patients with genetic mutation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/21/2008)..., New Haven, Conn.A conference on the social and ...ct of their production on the forests of Central a..., in Panama City, Panama. , The conference, Bio...s and Emerging Alternatives, is sponsored by the E...LTI) and the Program in Native Species Reforestati...
(Date:11/21/2008)..., Delhi, India "Waterproof" versions of popular ...complete submergence, have passed tests in farmers...eties are now close to official release by nationa...esh and India, where farmers suffer major crop los... rice per year. This is enough rice to feed 30 mil...
(Date:11/21/2008)..., Associated Professor, DSc Barbara Ann Halkier, ...he Faculty of Life Sciences, University of Copenha...received the prestigious award for her excellent r...ogically active substances in, for instance, plant...synthetic pathways, regulation and transport of gl...
(Date:11/21/2008)..., PROVIDENCE, R.I. [Brown University] Although A...chemical exposure from everyday household products... some toys, women do not readily connect typical h...and related adverse health effects, according to r... Health and Social Behavior . Brown University soc...
Breaking Biology News(10 mins):Conference to explore sustainability of biofuels 2From genes to farmers' fields 2From genes to farmers' fields 3The Danisco Award 2008 goes to D.Sc. Barbara Ann Halkier from Faculty of Life Sciences, Copenhagen 2Household exposure to toxic chemicals lurks unrecognized, researchers find 2Household exposure to toxic chemicals lurks unrecognized, researchers find 3Sedentary Lifestyle Accelerates Aging 10285 1Sedentary Lifestyle Accelerates Aging 10285 2Device zeroes in on small breast tumors 10281 1Device zeroes in on small breast tumors 10281 2BD to Present at the Merrill Lynch Global Pharmaceutical Biotechnology and Medical Device Conference 10279 1Its Good News for The Lungs 21 2782 1Its Good News for The Lungs 21 2782 2
... critical molecular events in the origin of fat ce...onic diseases, such as obesity and diabetes, as fa...ntrol, the researchers said. , The study finds tha...duces a key genetic switch in the transition from ... at University of Michigan Life Sciences Institute...
... critical molecular events in the origin of fat ce...onic diseases, such as obesity and diabetes, as fa...ntrol, the researchers said. , The study finds tha...duces a key genetic switch in the transition from ... at University of Michigan Life Sciences Institute...
... other using chemicals called neurotransmitters. O... GABA (gamma amino butyric acid), shows up in unus...rding to a new study from Washington University Sc...nvestigated metastatic neuroendocrine tumors, whic...rostate cancers that spread to other parts of the ...
...nce analysis of ancient DNA, a team of researchers...he evolutionary relationships shared by the large ...w World. , The work is reported in the August 9 is...ersity of Oxford and a team of researchers from Br..., Toward the end of the last Ice Age, around 13,00...
Other Biology News:System Drastically Cuts Down Botulism Detection Time 2The making of a fat cell 2Neurotransmitters signal aggressive cancer, offer potential for early diagnosis 2Neurotransmitters signal aggressive cancer, offer potential for early diagnosis 3DNA traces evolution of extinct sabertooths and the American cheetah-like cat 2
(Date:11/21/2008)...and New York, Nov. 21 El...stems Incorporated (Nasdaq: IMCL ) today,announ...nounced tender offer,by Lilly,s wholly-owned subs...utstanding shares of ImClone at a price of $70.00 ...dnight EST, on Thursday, November 20, 2008. , ...
(Date:11/21/2008)...v. 21 ChemDiv Inc. and Avineuro,P...r research and development,collaboration includin...nt,studies in areas of neurodegenerative and psyc...ded by Chemical Diversity Research Institute, Chem...w agreement provides for research funding of,clin...
(Date:11/21/2008)...v. 21 Gen-Probe,s (Nasda...an important new molecular tool to more,accuratel...ctions that are,associated with cervical cancer o...esentations and two scientific posters presented l... at the international conference of the,European ...
(Date:11/20/2008)...of NC,s biotechnology sector is $45.8 billion, 180... Nov. 20 North Carolina...g biotechnology enterprise during the past 10 year...ion, according to data released today at the North...Tolson, president and CEO of the Biotechnology Cen...
Breaking Biology Technology:Lilly Completes Cash Tender Offer for ImClone Systems 2Lilly Completes Cash Tender Offer for ImClone Systems 3ChemDiv and Avineuro Extend Collaboration on Alzheimer's Disease and Schizophrenia 2Promising Clinical Data on Gen-Probe's APTIMA(R) HPV Test Presented at Major European Medical Meeting 2Promising Clinical Data on Gen-Probe's APTIMA(R) HPV Test Presented at Major European Medical Meeting 3Promising Clinical Data on Gen-Probe's APTIMA(R) HPV Test Presented at Major European Medical Meeting 4Promising Clinical Data on Gen-Probe's APTIMA(R) HPV Test Presented at Major European Medical Meeting 5North Carolina's Biotechnology Investment Tops Billion-Dollar Mark; Battelle Study Quantifies Economic Dividends and Jobs 2North Carolina's Biotechnology Investment Tops Billion-Dollar Mark; Battelle Study Quantifies Economic Dividends and Jobs 3North Carolina's Biotechnology Investment Tops Billion-Dollar Mark; Battelle Study Quantifies Economic Dividends and Jobs 4North Carolina's Biotechnology Investment Tops Billion-Dollar Mark; Battelle Study Quantifies Economic Dividends and Jobs 5
...t total RNA from as few as 1 cell , Karen Do... total RNA microprep kit provides a,convenient... of cells. For,the purification, RNA is bound to...organic extraction and alcohol precipitation. The ...e DNA contamination and is suitable for,subseque...
...old higher transformation efficiency of ligated DN...ener ,Stratagene Cloning Systems, Inc. , Strat... line,significantly improves the transformation ...0-Gold ultracompetent cells* yielded,transfor...o 25-fold higher than,other commercially availab...
...asma PCR Primer Set for fast and easy detection of...rington ,Yale University , D. R. Staggs ,Gen...ne , Mycoplasma contamination of mammalian cell ... transfection reagents. 1 Cells must be free of,...ts of LipoTAXI ,transfection reagent and D...
... transfection conditions using LipoTAXI transfecti...ne Cloning Systems , Soverin Karmiol ,Clonetic... transfection reagent is a novel liposome reagent ...fection efficiencies for adherent and,suspended ... amounts of LipoTAXI,transfection reagent and DN...
Other Biology Technology:Fast Isolation of Total RNA from Small Numbers of Cells 2Fast Isolation of Total RNA from Small Numbers of Cells 3Fast Isolation of Total RNA from Small Numbers of Cells 4Fast Isolation of Total RNA from Small Numbers of Cells 5Fast Isolation of Total RNA from Small Numbers of Cells 6New Competent Cells for Highest Transformation Efficiencies 2New Competent Cells for Highest Transformation Efficiencies 3New Competent Cells for Highest Transformation Efficiencies 4New Competent Cells for Highest Transformation Efficiencies 5New Competent Cells for Highest Transformation Efficiencies 6New Competent Cells for Highest Transformation Efficiencies 7New Competent Cells for Highest Transformation Efficiencies 8Mycoplasma Contamination Reduces the Effect of Lipid-Mediated Transfection,of Mammalian Cells 2Mycoplasma Contamination Reduces the Effect of Lipid-Mediated Transfection,of Mammalian Cells 3Low-Toxicity, Lipid-Mediated Transfection of Mammalian Cells 2Low-Toxicity, Lipid-Mediated Transfection of Mammalian Cells 3Low-Toxicity, Lipid-Mediated Transfection of Mammalian Cells 4Low-Toxicity, Lipid-Mediated Transfection of Mammalian Cells 5
Apoptosis Detection Systems and Reagents
Normal Bovine Serum from Equitech-Bio
Adult Bovine Serum US Origin
...ntains 4 deuterium atoms at the 9, 10, 12, and 13 ...tandard for the quantification of 13(S)-HODE by GC...by incubation of linoleic acid with plant and mamm...the adhesion of tumor cells to the endothelium at ...
Biology Products: