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Mutation may cause inherited neuropathy
Date:12/25/2007

, neurons that transmit signals over long distances will suffer more.

Its very common for neuropathies to affect neurons with the longer axons, for example those that innervate the legs and feet, says Popko. It has been previously suggested that hereditary sensory neuropathy might be connected with disabled trafficking along the axons. There have been mutations found in two genes that form a complex essential for survival of sensory neurons, and this complex is thought to be transported along the neurons by dynein.

This study lays the groundwork for the search for disruptions of this cargo transporting complex in human patients with sensory neuropathy, write the authors in their paper.

They are already looking at human patients for similar mutations. And theyre working further on answering new questions, including: what are the binding partners of dynein that are disrupted in diseases, and why does this affect sensory and not motor neurons"


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Contact: Scot Roskelley
scot.roskelley@uchospitals.edu
773-702-6241
University of Chicago Medical Center
Source:Eurekalert

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