Navigation Links
Mutation in gene that's critical for human development linked to arrhythmia
Date:12/27/2011

, found that slight alterations in the structure of the Tbx3 gene alter the level of the protein in mice. When this happens, it can impair the electrical signal in the sinoatrial node and block the atrioventricular node, which conducts electrical signals from the atria to the ventricles. The result is lethal arrhythmias in embryonic and adult mice.

This discovery has implications for the potential to regenerate functional heart tissue, according to Moon. "There's a big effort to regenerate heart muscle," she says. "But if the muscle can't conduct electrical signals, it's not going to do any good; we also need to be able to regenerate conduction tissues to regulate that muscle."

Arrhythmia is not the first problem related to mutations in the TBX3 gene. In humans, TBX3 mutations have been shown to cause limb malformations in people with ulnar-mammary syndrome, an inherited birth disorder characterized by abnormalities of the bones in the hands and forearms and underdeveloped sweat and mammary glands.

In her future research, Moon wants to discover specifically how Tbx3 regulates the behavior of cells in the cardiac conduction system and whether cells that don't have enough Tbx3 die or turn into some other kind of cells.

"It turns out that Tbx3 is a lot more important in the heart than we realized," Moon says.


'/>"/>

Contact: Phil Sahm
phil.sahm@hsc.utah.edu
801-581-2517
University of Utah Health Sciences
Source:Eurekalert

Page: 1 2

Related biology news :

1. Scientists discover second-oldest gene mutation
2. BGI reports study results on frequent mutation of genes encoding UMPP components in kidney cancer
3. Cell surface mutation protects against common type of malaria
4. New approaches may prevent certain side effects in BRAF mutation-positive melanoma
5. Mutation in gene associated with rare eye disease also contributes to bladder cancer growth
6. Study tracks mutations causing CDA II back to the Roman Empire
7. New mutations in leukemia: Researchers found mechanism that can help design future therapies
8. Scientists identify mutation in SIGMAR1 gene linked to juvenile ALS
9. Mutations not inherited from parents cause more than half the cases of schizophrenia
10. Research discovers frequent mutations of chromatin remodeling genes in TCC of the bladder
11. As new data wave begins, a gene study in one disease discovers mutations in an unrelated disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/3/2015)... JOSE, Calif. , Aug. 3, 2015 ... of human interface solutions, today announced that members of ... community at the Pacific Crest Global Technology Leadership Forum ... Time. The conference will be held at the Sonnenalp ... The presentation may include forward-looking information. An ...
(Date:7/31/2015)... de julio de 2015 La 10 th ... por medio de BGI del 22 al 25 de octubre de ... Este año, la conferencia celebra su décimo aniversario. Desde ... en una de las reuniones anuales más influyentes del mundo ... reuniones más dinámicas, entusiastas y mejores a nivel científico. ...
(Date:7/27/2015)... , July 27, 2015  Synaptics Inc. ... human interface solutions, today announced that Huawei has ... touchscreen solution for its stylish smartwatch. Huawei chose ... proven reliability, low power and highly responsive human ... finger. Huawei designers also required a classic round ...
Breaking Biology News(10 mins):La 10th International Conference on Genomics (ICG-10) se llevará a cabo en octubre 2La 10th International Conference on Genomics (ICG-10) se llevará a cabo en octubre 3Synaptics Touchscreen Solution Powers New Huawei Watch 2Synaptics Touchscreen Solution Powers New Huawei Watch 3
... in Oregon,s Willamette Basin to protect at-risk animals won,t ... will absorb more carbon from the atmosphere and vice ... study, to be published this month in the ... hypothetical payments that were given to landowners to voluntarily ...
... UC San Diego are collaborating with scientists from ... map patterns of biodiversity and land use in ... with climate models, will project how climate change ... for setting aside conservation easements. Wildlife, people ...
... Francisco Gonzlez, president of the BBVA Foundation: "One of the ... the environment and, especially, of biodiversity. This is a task ... all play our part. At BBVA, we believe it is ... of the natural resource base" United States researchers ...
Cached Biology News:Incentives for carbon sequestration may not protect species 2Biodiversity maps developed by UCSD scientists will help guide conservation measures in East Africa 2Biodiversity maps developed by UCSD scientists will help guide conservation measures in East Africa 3BBVA Foundation Awards for Biodiversity Conservation 2BBVA Foundation Awards for Biodiversity Conservation 3BBVA Foundation Awards for Biodiversity Conservation 4
(Date:8/3/2015)... , ... August 03, 2015 , ... Nine field days ... Illinois and Indiana. Hosted by the Soil Health Partnership , the field days ... environmental benefits while potentially increasing farm productivity and income. , Brent Bible has practiced ...
(Date:8/3/2015)... 2015 E-QURE Corp. (OTCQB: EQUR), ... Bio-electrical Signal Therapy device ("BST Device"), a new and ... heal chronic wounds, today announced that the Company has ... distributor specializing in medical devices, for the marketing and ... a 70 years old, sales, marketing and distribution company ...
(Date:8/3/2015)... -- According to a new market report ... Asia to Witness Highest Growth by ... culture market was valued at US$ 586.1 Mn in 2014 ... 29.1% to account for US$ 2,717.6 Mn by 2020. ... 3D cell culture refers to a process ...
(Date:8/3/2015)... ... 2015 , ... Sterlitech Corporation introduces the compact, quiet, and ... laboratory equipment. With optimized features, such as PTFE-coated contact surfaces, an oil-free design, ... solution for a broad range of vacuum filtration applications. , Featuring a 1/7 ...
Breaking Biology Technology:Soil Health Field Days Kick Off Throughout Midwest 2Soil Health Field Days Kick Off Throughout Midwest 3E-QURE Corp Signs Second Distribution Agreement in Israel 2E-QURE Corp Signs Second Distribution Agreement in Israel 3Global 3D Cell Culture Market Will Reach US$ 2,717.6 Million by 2020: Persistence Market Research 2Global 3D Cell Culture Market Will Reach US$ 2,717.6 Million by 2020: Persistence Market Research 3Global 3D Cell Culture Market Will Reach US$ 2,717.6 Million by 2020: Persistence Market Research 4Sterlitech Launches New Line of Vacuum Pumps 2
... June 30, 2011 Dendreon Corporation (Nasdaq: ... support broad availability for on-label use of PROVENGE® ... treatment of asymptomatic or minimally symptomatic metastatic castrate ... The U.S. Food and Drug ...
... 2011 ( HCCS ) Health Care Compliance Strategies, ... competency training, today announced the release of an update ... SimPL - The Simple Platform for Learning. This ... existing online training and eLearning functions. (Logo: ...
... National Parkinson Foundation (NPF) has awarded more than $1 ... individual investigators awards program, NPF is supporting work to advance ... biomarker study, 2) a clinical trial to treat memory impairment, ... for sleep apnea in PD. "Each of these ...
Cached Biology Technology:Dendreon Announces Increased Capacity and Significant Reimbursement Decisions Supporting Broad Availability of PROVENGE 2Dendreon Announces Increased Capacity and Significant Reimbursement Decisions Supporting Broad Availability of PROVENGE 3Dendreon Announces Increased Capacity and Significant Reimbursement Decisions Supporting Broad Availability of PROVENGE 4HCCS Releases Classroom Management Features for Low Cost Learning Management System 2National Parkinson Foundation Awards More Than $1 Million for Research 2National Parkinson Foundation Awards More Than $1 Million for Research 3
Mycoplasma and virus tested...
Bethyl Laboratories Ready-To-Use IHC Bluing Reagent is used following IHC hematoxylin counterstaining with immunohistochemical procedures. Shelf-Life: 1 year from date of receipt...
Edited by Benjamin Lewin (1997) • This book gives an integrated account of the structure and function of genes in both prokaryotic organisms and is thoroughly up to date with the latest thinking...
... is the most effective ... PCR products. TOPO TA ... TOPO vectors are supplied ... topoisomerase I. This enables ...
Biology Products: