Navigation Links
Mutation altering stability of surface molecule in acid enables H5N1 infection of mammals
Date:2/28/2013

A single mutation in the H5N1 avian influenza virus that affects the pH at which the hemagglutinin surface protein is activated simultaneously reduces its capacity to infect ducks and enhances its capacity to grow in mice according to research published ahead of print today in the Journal of Virology.

"Knowing the factors and markers that govern the efficient growth of a virus in one host species, tissue, or cell culture versus another is of fundamental importance in viral infectious disease," says Charles J. Russell of St. Jude Children's Research Hospital, Memphis, TN, an author on the study. "It is essential for us to identify influenza viruses that have increased potential to jump species, to help us make decisions to cull animals, or quarantine humans." The same knowledge "will help us identify targets to make new drugs that stop the virus [and] engineer vaccines."

Various influenza viruses are spreading around the globe among wild birds, but fortunately, few gain the ability to jump to humans. However, those that do, and are able to then spread efficiently from person to person, cause global epidemics, such as the infamous pandemic of 1918, which infected one fifth and killed an estimated 2.7 percent of the world's population. Occasionally, one of these viruses is exceptionally lethal. For example, H5N1 has killed more than half of the humans it has infected. The specter of such a virus becoming easily transmissible among humans truly frightens public health officials. But understanding the mechanisms of transmission could help microbiologists find ways to mitigate major epidemics.

When influenza viruses infect birds, the hemagglutinin surface protein of the virus is activated by acid in the entry pathway inside the host cell, enabling it to invade that cell. In earlier work, Russell and collaborators showed that a mutant version of the influenza H5N1 virus called K58I that resists acid activation, loses its capacity to
'/>"/>

Contact: Jim Sliwa
jsliwa@asmusa.org
202-942-9297
American Society for Microbiology
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Will a genetic mutation cause trouble? Ask Spliceman
2. BRG1 mutations confer resistance to hormones in lung cancer
3. Researchers reveal how a single gene mutation leads to uncontrolled obesity
4. Genetic mutation found in familial chronic diarrhea syndrome
5. UGA scientists reveal genetic mutation depicted in van Goghs sunflower paintings
6. Genetic mutation depicted in van Goghs sunflower paintings revealed by scientists
7. Gene mutation identified as contributor to autism spectrum disorders
8. A single stem cell mutation triggers fibroid tumors
9. Common genetic mutation increases sodium retention, blood pressure
10. UC Davis scientists find new role for P53 genetic mutation -- initiation of prostate cancer
11. Gene mutations cause massive brain asymmetry
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/19/2014)... VEGAS , Dec. 18, 2014   LaunchKey ... built for the post-password and Internet of Things era, ... seed funding. The venture round was led by Metamorphic ... Capital, Rimrock Venture Partners, VegasTechFund, and others.  LaunchKey has ... new funding to expand its team and bring LaunchKey ...
(Date:12/17/2014)...  HITLAB SM announced today its completion ... confirm its adherence to current U.S. Food and ... to conduct regulated smart device and smart phone ... safety and research quality. "HITLAB is ... delivery with innovative technology," said Laura Pugliese ...
(Date:12/17/2014)...  Automation is fundamentally transforming the travel experience ... international borders. Over the past decade, ePassports, biometric ... travelers to self process through border control via ... an increasing number of airports, seaports, and land ... to Maxine Most , Principal at Acuity ...
Breaking Biology News(10 mins):LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 2LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 3HITLAB Completes GCP Audit for FDA Smart Device & App Compliance 2Automated Border Control (ABC) Transforms the Global Travel Experience With More Than 2500 ABC eGates and APC Kiosks Deployed In Airports, Seaports, and Land Borders Worldwide 2
... of Manchester funded by the Fungal Research Trust have ... - in our pillows. , ... pillows, is most likely to cause disease; and the ... of death in leukaemia and bone marrow transplant patients. ...
... Left untreated, prostate cancer cells often metastasize, or spread, ... extremely painful. , More than 80 percent of ... disease in their bones. But scientists know very little ... in bone tissue and produce the dense bony lesions ...
... money from Johns Hopkins Institute of Cell Engineering, a Johns ... between the health of stem cells and the length of ... are repetitive stretches of DNA that protect chromosomes in much ... fabric from fraying. Each time a cell divides, its chromosome ...
Cached Biology News:Pillows - a hot bed of fungal spores 2Prostate cancer uses Wnt signaling proteins to promote growth of bone tumors 2Prostate cancer uses Wnt signaling proteins to promote growth of bone tumors 3A little telomerase isn't enough 2A little telomerase isn't enough 3A little telomerase isn't enough 4
(Date:12/24/2014)... (PRWEB) December 23, 2014 Nashville Fertility ... was elected treasurer for the American Society for Reproductive ... knowledge and research in reproductive medicine. In his ... seat on the executive board and will have a ... Dr. Hill has actively supported ASRM since 1984 when ...
(Date:12/24/2014)... 2014 China Biologic Products, Inc. (NASDAQ: ... fully integrated plasma-based biopharmaceutical company in ... subsidiary, Shandong Taibang Biological Products Co. Ltd., has ... China Food and Drug Administration (the "CFDA") for ... disclosed in the Company,s public filings, the CFDA ...
(Date:12/24/2014)... 23, 2014 Sigma-Aldrich Corporation (NASDAQ: ... period under the Hart-Scott-Rodino Antitrust Improvements Act (HSR ... December 22, 2014, thereby completing the U.S. HSR ... acquisition of the Company by Merck KGaA, Darmstadt, ... another condition to closing the transaction, which remains ...
(Date:12/22/2014)... The Center for Professional Innovation ... training across the life sciences industry, has partnered with ... to provide the organization's members with discounted classroom courses, ... the more than 350 sessions across 80 course titles. ... when registering for a public course at ...
Breaking Biology Technology:Nashville Fertility Center Announces Dr. George A. Hill Selected to Serve as ASRM Treasurer for 2014-15 2Nashville Fertility Center Announces Dr. George A. Hill Selected to Serve as ASRM Treasurer for 2014-15 3China Biologic Receives GMP Certification for New Coagulation Factor Facility 2China Biologic Receives GMP Certification for New Coagulation Factor Facility 3Acquisition of Sigma-Aldrich by Merck KGaA, Darmstadt, Germany, Receives U.S. Antitrust Clearance 2Acquisition of Sigma-Aldrich by Merck KGaA, Darmstadt, Germany, Receives U.S. Antitrust Clearance 3CfPIE Announces Partnership with the Society for Clinical Data Management 2CfPIE Announces Partnership with the Society for Clinical Data Management 3
... Immtech Pharmaceuticals, Inc. (NYSE Alternext US: IMM.BC) today ... & Company, LLP as its independent registered public ... the Company,s independent registered public accounting firm was ... The appointment will result in cost savings for ...
... AND EUROPE FOR TECHNOLOGY USED IN CORGENIX NEXT ... Corgenix Medical Corporation (OTC Bulletin Board: CONX), ... kits, has received notification of two new patents ... licensing rights outside of Japan. The technology ...
... 20 /PRNewswire-Asia/ -- TaiGen Biotechnology Co., Ltd., ... drugs to treat infectious diseases, cancer and diabetes-related ... USD through the private placement of preferred C ... including MPM Capital, National Development Fund, YFY group, ...
Cached Biology Technology:Immtech Announces Appointment of Virchow Krause as Independent Registered Public Accounting Firm 2Corgenix Receives Two Additional Patents on AtherOx(R) Technology 2Corgenix Receives Two Additional Patents on AtherOx(R) Technology 3TaiGen Biotechnology Secures 37 Million USD in Series C Round Financing 2
... Activity Kit ADAM17 Activity Kit TNF-α Converting ... PROTECT FROM LIGHT. AVOID FREEZE/THAW CYCLES. The ... and sensitive assay designed to measure human ... samples and for screening enzyme inhibitors. An ...
... unique agarose-digesting enzyme developed by Promega for ... or RNA from agarose gels. The enzyme ... (LMP) agarose melted at 6575C does not ... temperature before hydrolysis. Simply place the tube ...
...
... FREEZE. Nuclear matrix proteins (NMPs) make up the ... associated with such functions as DNA replication, RNA ... matrix has been shown to be highly insoluble ... that cell death releases soluble nuclear matrix proteins ...
Biology Products: