Navigation Links
Mutant mouse reveals new wrinkle in genetic code, say UCSF scientists
Date:4/28/2011

utations turned out to delete a protein called Rpl38, one of 79 proteins that make up the mouse ribosome. Without Rpl38, the ribosome in the tail short mouse still worked, but it lost the ability to control which proteins it expressed an ability scientists never thought the ribosome had in the first place. Moreover, the effect was not generalized throughout the body of the mouse, but specific only to certain tissues.

In early fetal development, the loss of Rpl38 caused certain parts of the backbone to grow and develop as if they were elsewhere in the spine thus the extra ribs in the neck. Mutations in the proteins of human ribosomes can also lead to unexpected tissue-specific congenital birth defects including malformations of the spine, face, limbs, heart and other organs. The reasons why have been a mystery, but the explanation may be that the ribosome plays a fundamental regulatory role in embryonic development.

"It dictates where and when the final outcomes of gene products are expressed," said Barna. "Therefore the genetic code has a previously unrecognized set of instructions that are carried out by the ribosome to control cell behavior. For example, whether or not a vertebrate has a pair of ribs associated with it."

The work also suggests that ribosomes could act differently in different tissues in the body, adding an entirely new layer of complexity to the already complex program by which the genetic code is expressed in living creatures.


'/>"/>

Contact: Jason Socrates Bardi
jason.bardi@ucsf.edu
415-502-4608
University of California - San Francisco
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Could mutant flies give epilepsy sufferers greater peace of mind?
2. Mutant prions help cells foil harmful protein misfolding
3. Oncogene AEG-1 strongly predicts response to erlotinib treatment in EGFR-mutant lung cancer
4. Mechanism behind demethylation pinpointed in APC gene mutants
5. Mutant gene link to West Nile virus in horses
6. Small molecules might block mutant protein production in Huntingtons disease
7. 200,000 rice mutants available worldwide for scientific investigation
8. 200,000 rice mutants available worldwide for scientific investigation
9. Mutant host cell protein sequesters critical HIV-1 element
10. Freeway air bad for mouse brain
11. Nicotine does not promote lung cancer growth in mouse models
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/22/2014)... examined the survival rates of 12 different shark ... fishing operations found large differences in survival,rates across ... scalloped hammerhead being the most,vulnerable. The study, led ... Rosenstiel School of,Marine and Atmospheric Science and UM ... information to consider for future conservation measures for ...
(Date:7/22/2014)... that split light with uncanny precision are key ... computers that manipulate light instead of electricity. But ... etching them with a precise beam of electrons, ... researchers at Princeton and Columbia universities have proposed ... customize and grow these specialized materials, known as ...
(Date:7/22/2014)... that drinking milk helps make their bones strong or that fish ... idea that if something is good for us, it must surely ... of Consumer Research , when children hear about the benefits of ... that when food is presented to children as making them strong ... how to read or count, they would conclude the food is ...
Breaking Biology News(10 mins):New study reveals vulnerability of sharks as collateral damage in commercial fishing 2Technique simplifies the creation of high-tech crystals 2Technique simplifies the creation of high-tech crystals 3
... and Avalon Technology partner on new ... aviation-related ... Inc.,(OTC Bulletin Board: CTHH) ( http://www.catcherinc.com ), a leader ... Technology ( http://www.avalontechnology.com ), a leading,integrator of managed mobile ...
... resulting from higher CO2 could boost the amount ... new study looks at a poorly understood process ... Sayer, postdoctoral fellow at the Smithsonian Tropical Research ... University of Minnesotas Department of Ecology, Evolution and ...
... Boulder, CO, USA Two hundred years ago Lewis and ... deal of scientific research with its descriptions of territory acquired ... be disappointed by the absence of living megafauna, the area ... volume published by the Geological Society of America makes clear ...
Cached Biology News:CATCHER to be Deployed at Major U.S. Airline 2CATCHER to be Deployed at Major U.S. Airline 3CATCHER to be Deployed at Major U.S. Airline 4Complex carbon picture clearer 2
(Date:7/22/2014)... July 22, 2014 Quorum Review IRB, the ... for large clinical trials called Quick Step™ . The ... to address the research industry’s need for seamless study start-up ... is available for studies planning 50 or more North American ... planned North American site count of 80 or more. Qualifying ...
(Date:7/22/2014)... (PRWEB) July 22, 2014 Biofeedback ... hyperactivity disorder (ADHD) is diagnosed, selecting medication to best ... error. Analyzing brain patterns by using electroencephalography (EEG) can ... and thus lower the risk of adverse drug events. ... and Biomarkers” in the current issue of the ...
(Date:7/21/2014)... (PRWEB) July 21, 2014 With ... simple programming, the new Cole-Parmer® Digital Gear ... is easy to operate for automated process applications. ... hands-free dispensing. The batch count function counts down ... or totalizer tracks amount dispensed across multiple cycles. ...
(Date:7/21/2014)... , July 21, 2014  Mike Patterson, CEO ... $1.6 million in Series Seed B funding to ... sensors for the life science, defense, intelligence, and ... Partners led the round and was joined by ... Said Patterson , "This round of funding ...
Breaking Biology Technology:Quorum Review IRB Launches New Quick Step™ Service for Large Clinical Trials 2Quorum Review IRB Launches New Quick Step™ Service for Large Clinical Trials 3Analyzing Brain Patterns with EEG Can Help Predict Effective Use of Medication 2Analyzing Brain Patterns with EEG Can Help Predict Effective Use of Medication 3New Easy-View Cole-Parmer Digital Gear Pump Drive Makes Performance Monitoring Effortless 2Global Graphene Manufacturing Leader, Graphene Frontiers, Receives Series Seed B Funding To Assure Production Of The Next Generation Of Biological And Chemical Sensor Technology 2
... , June 17 OncoMed Pharmaceuticals, Inc. and Bayer ... alliance to discover, develop and commercialize novel anti-cancer stem cell therapeutics ... of tumor cells believed to play a significant role in the ... , , ...
... The Netherlands and SEATTLE , ... the development of innovative products for,hemostasis and regenerative medicine, ... CSL Behring for the clinical and commercial supply of,plasma-based ... is a leader in the plasma protein therapeutics industry ...
... Researchers at Rensselaer Polytechnic Institute have developed a ... that measure only billionths of a meter thick. ... works on nearly any surface including silicon wafers, ... manufacturing. Sang-Kee Eah, assistant professor in the ...
Cached Biology Technology:OncoMed Pharmaceuticals and Bayer Schering Pharma Announce Strategic Alliance to Develop Anti-Cancer Stem Cell Therapeutics 2OncoMed Pharmaceuticals and Bayer Schering Pharma Announce Strategic Alliance to Develop Anti-Cancer Stem Cell Therapeutics 3OncoMed Pharmaceuticals and Bayer Schering Pharma Announce Strategic Alliance to Develop Anti-Cancer Stem Cell Therapeutics 4OncoMed Pharmaceuticals and Bayer Schering Pharma Announce Strategic Alliance to Develop Anti-Cancer Stem Cell Therapeutics 5ProFibrix and CSL Behring Enter Into Fibrinogen and Thrombin Supply Agreement 2Researchers develop ultra-simple method for creating nanoscale gold coatings 2
OmniSlide thermal Cycler for slide applications. 20 slide capacity. Humidity Chamber. Slide Rack can be transferred directly to Wash Module to avoid handling individual slides....
... are cytopathic effect inhibition assays, also known as ... tissue culture supernatents; serum from PK studies and ... is defined as the quantity of interferon required ... viral infection by 50%. All standards ...
Request Info...
...
Biology Products: