Navigation Links
Mutant mouse reveals new wrinkle in genetic code, say UCSF scientists
Date:4/28/2011

that the skeleton was malformed it seemed to be misplaced. The neck vertebrae had ribs and resembled vertebrae lower in the spine. It was as if the body plan of this mouse had been incorrectly mixed up in early development, though it was beyond the ability of scientists in those days to determine why.

Through the decades, the mouse remained a curiosity of sorts. Its progeny were carefully bred year after year, but decades passed before anyone could determine which genes were responsible for its unusual features.

Finally, a few years ago, Barna and her colleagues, became interested in the mouse, and she worked with scientists at the National Institute of Genetics in Japan to identify the exact mutations that cause the malformations. A developmental biologist herself, Barna suspected that the mouse's peculiar skeletal structures suggested some sort of anomalous "patterning" in early development, where one part of the body forms incorrectly in the shape of a different part. What they found, said Barna, was a complete surprise.

A MASSIVE MOLECULAR MACHINE

The mutations turned out to be in the ribosome, a massive molecular machine that makes proteins and are common to all forms of life. They can be found in every cell in every tissue of the human body, and scientists believe that similar versions have been inside every cell of every creature that ever lived whether cat, carp, cholera or Caesar.

The ribosome is so common because it plays a central role in biology by making proteins that do everything from building the body's tissues to carrying out crucial biological functions, like breaking down food in the gut and encoding memories in the brain. Despite its importance, scientists had always assumed that the ribosome was something of an automaton a machine that simply took instructions from a creature's genetic code and spit out proteins. Mutations in the tail short mouse, however, showed otherwise.

These m
'/>"/>

Contact: Jason Socrates Bardi
jason.bardi@ucsf.edu
415-502-4608
University of California - San Francisco
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Could mutant flies give epilepsy sufferers greater peace of mind?
2. Mutant prions help cells foil harmful protein misfolding
3. Oncogene AEG-1 strongly predicts response to erlotinib treatment in EGFR-mutant lung cancer
4. Mechanism behind demethylation pinpointed in APC gene mutants
5. Mutant gene link to West Nile virus in horses
6. Small molecules might block mutant protein production in Huntingtons disease
7. 200,000 rice mutants available worldwide for scientific investigation
8. 200,000 rice mutants available worldwide for scientific investigation
9. Mutant host cell protein sequesters critical HIV-1 element
10. Freeway air bad for mouse brain
11. Nicotine does not promote lung cancer growth in mouse models
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/9/2015)... 2015 Synaptics Inc. (NASDAQ: SYNA ), a ... it will report financial results for the third quarter ... the close of market. The company will host a ... p.m. PT (5:00 p.m. ET), during which management may ... the live call, analysts and investors should dial 888-438-5524 ...
(Date:4/2/2015)... , April 2, 2015 According ... 2015 attributed to somewhat higher than 125 MSEK. This ... year-end report 2014 that revenues for Q1 2015 would ... company reported for Q4 2014. The operating result for ... negative. The complete interim report will as previously communicated ...
(Date:3/31/2015)... NEW YORK , March 31, 2015   ... announced the launch of the Post-Surgical Pain Management TRACKER, ... data products tracking usage trends in the medical device ... monthly access to data including treatment volumes, market share, ... manage the pain associated with joint surgery. ...
Breaking Biology News(10 mins):Synaptics to Report Third Quarter Results on April 23 2Fingerprint Cards Revises Revenues for Q1 2015 2Guidepoint Launches Post-Surgical Pain Management TRACKER 2Guidepoint Launches Post-Surgical Pain Management TRACKER 3
... Spring Harbor Laboratory will host the inaugural conference ... project to create a virtual center in cyberspace ... conference, titled "Bringing Plant and Computing Scientists Together ... for April 7-9, 2008, will take the first ...
... DALLAS April 4, 2008 Researchers at UT ... method to screen small synthetic molecules and pull out ... less expensively than current methods. In one screen ... new technique quickly singled out five promising candidates that ...
... tablets, might not be that beneficial for the majority ... access journal Genome Biology. Although this trace element is ... we have lost some of the need for selenium, ... plasma, when our evolutionary ancestors left the oceans and ...
Cached Biology News:iPlant Kickoff Conference at CSHL begins tackling plant biology's grand challenges 2iPlant Kickoff Conference at CSHL begins tackling plant biology's grand challenges 3Synthetic molecules may be less expensive alternative to therapeutic antibodies, researchers find 2Synthetic molecules may be less expensive alternative to therapeutic antibodies, researchers find 3Supplements are not nutritious 2
(Date:5/5/2015)... , May 5, 2015  Renova™ Therapeutics, a ... heart failure and other chronic diseases, has engaged ... analysis designed to reflect the healthcare patterns of ... model will be used to characterize the impact ... have on those groups of patients and the ...
(Date:5/5/2015)... , May 5, 2015 ImmunoCellular Therapeutics, ... Andrew Gengos , President and Chief Executive Officer, ... 2015. DATE:  Thursday, May 7, 2015     ... http://VirtualInvestorConferences.com > click the red "register/ watch ... live, interactive online event where investors are invited ...
(Date:5/5/2015)... (PRWEB) May 05, 2015 A comment ... a wide range of key photonics technologies – regulations ... competitiveness of U.S. industry. To help the community understand ... 12 May on the proposed changes to U.S. ... covered by International Traffic in Arms Regulations (ITAR). , ...
(Date:5/5/2015)... --Research and Markets ( http://www.researchandmarkets.com/research/x5gjj3/clinical ) ... Laboratory, Molecular Diagnostics and Genomic Testing Services Market ... Version" report to their offering. ... molecular diagnostics and pharmacogenics hold the promise of ... is moving out of the national and regional ...
Breaking Biology Technology:RAND Health Advisory Services modeling heart failure patient outcomes to inform potential impact of Renova Therapeutics lead product candidate 2RAND Health Advisory Services modeling heart failure patient outcomes to inform potential impact of Renova Therapeutics lead product candidate 3ImmunoCellular Therapeutics to Webcast Live at VirtualInvestorConferences.com on May 7 2Comments needed now from photonics industry on revisions of U.S. export rules 2Comments needed now from photonics industry on revisions of U.S. export rules 3Comments needed now from photonics industry on revisions of U.S. export rules 4Global Clinical Laboratory, Molecular Diagnostics and Genomic Testing Services Market Trends and Forecast 2015 to 2019 2
... Sept. 13 The Convergent Procedure, a novel ... epicardial ablation products from nContact Surgical, Inc. (nContact), ... of the EACTS (European Association for Cardio-Thoracic Surgery) ... medical professionals attended the 2010 Techno-College Programme to ...
... MOUNTAIN VIEW, Calif., Sept. 10 VIVUS, Inc. (Nasdaq: ... will present an overview of the company at four ... presentation schedule is as follows:Bank of America Merrill Lynch ... officerSeptember 16, 2010 at 2:30 p.m. BST Bank of ...
... 10 Paratek Pharmaceuticals, Inc. today announced the ... will be the subject of several poster presentations ... and Chemotherapy (ICAAC).  Dr. Stuart Levy, co-founder and ... delivering a talk at a symposium on antibiotic ...
Cached Biology Technology:The Convergent Procedure for the Treatment of Chronic Atrial Fibrillation Highlighted at EACTS Annual Meeting in Geneva 2VIVUS to Present at Four Upcoming Investor Conferences 2Paratek to Present Clinical Data at the 50th Interscience Conference on Antimicrobial Agents and Chemotherapy 2Paratek to Present Clinical Data at the 50th Interscience Conference on Antimicrobial Agents and Chemotherapy 3