Navigation Links
Mutant gene identified as villain in hardening of the arteries
Date:12/18/2007

New Haven, Conn.A genetic mutation expands lesions in the aorta and promotes coronary atherosclerosis, more commonly known as hardening of the arteries, according to a study by Yale School of Medicine in Cell Metabolism.

The researchers found that mice engineered without the Akt1 gene and fed a high cholesterol diet had many more signs of aortic atherosclerosis compared to their littermates. And, surprisingly, their coronary lesions were similar to humans, say the scientists.

About 20 percent of the mice died spontaneously, perhaps due to an acute heart attack, said William Sessa, senior author of the study, professor of pharmacology, and director of Yales vascular biology and therapeutics program.

Atherosclerosis is a chronic inflammatory response in arterial walls, in large part due to deposits of lipoproteinswhich are plasma proteins that carry cholesterol and triglycerides. The "hardening" or "furring" of the arteries is caused by plaque formation.

In the vascular wall, Akt plays an important role in regulating the development of endothelial cells, which line the entire circulatory system, from the heart to the smallest capillary. Endothelial cells play an important role in regulating blood pressure, in blood clotting, in plaque formation in the arteries, and in formation of new blood vessels.

The major finding of this study is that an absence of Akt1 aggravates atherosclerotic lesions, promotes coronary atherosclerosis, and may be a model of acute coronary syndromes, Sessa said. Specific activation of Akt1 may provide a therapeutic approach to decrease formation of lesions in the arterial wall and promote plaque stabilization to prevent an acute heart attack.

One concern, he said, is that specific drugs are being developed to inhibit Akt in cancer patients to reduce progression of tumors, and that these drugs may also promote hardening of the arteries.


'/>"/>

Contact: Jacqueline Weaver
jacqueline.weaver@yale.edu
203-432-8555
Yale University
Source:Eurekalert

Page: 1

Related biology news :

1. Mutant sperm guide clinicians to new diseases
2. New study shows greenback cutthroat trout involved in recovery effort misidentified
3. Brain network related to intelligence identified
4. The reservoir of Marburg virus identified in a species of fruit bat
5. Genes that both extend life and protect against cancer identified
6. Genes identified to protect brassicas from damaging disease
7. Newly-identified exercise gene could help with depression
8. Best treatment identified to reduce deadly Staph infections
9. New approach for attacking lupus identified
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/10/2014)... 8, 2014 You,ve been here before: you desperately ... remember your password, site key or the answer to your ... grade teacher? Today, Hoyos Labs , ... that will finally put an end to the frustration that ... . 1U leverages a user,s smartphone to acquire his ...
(Date:12/10/2014)... Dec. 08, 2014 Research and Markets ... of the "Biometrics Market in Japan 2014-2018" ... http://photos.prnewswire.com/prnh/20130307/600769 The integration ... as rural banking and upgradation of the driver,s ... in the market. Besides the aforementioned projects, biometrics ...
(Date:12/4/2014)... BEACH GARDENS, Fla. , Dec. 3, 2014 ... management solutions, today announced that its DigitalPersona ® ... 4500 fingerprint readers have been deployed throughout First ... , South Carolina ... headquartered in Southern Pines, North Carolina ...
Breaking Biology News(10 mins):The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 2The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 3Biometrics Market in Japan 2014-2018: Key Vendors are DDS, Fujitsu, Hitachi and NEC 2First Bank Partners with Crossmatch to Increase Log In Security 2First Bank Partners with Crossmatch to Increase Log In Security 3
... U.S. is produced by coal. Yet this power leaves behind ... College of Engineering at the University of Tennessee, Knoxville, has ... change that. Peter Liaw, professor and Ivan ... colleagues have received a $300,000 Clean Coal Research Award for ...
... this year,s Gulf of Mexico hypoxic zone could range from ... as 6,213 square miles. The wide range is the result ... on Mississippi River nutrient inputs compiled annually by the U.S. ... covering an area slightly larger than the state of Rhode ...
... been announced as the overall winner in this year,s Wellcome Image ... during a surgical procedure to treat a patient with epilepsy, the ... Professor Alice Roberts, who was a member of the judging panel, ... makes it so different from most images of the surface of ...
Cached Biology News:University of Tennessee professor receives funding for clean coal research 2NOAA: Gulf of Mexico 'dead zone' predictions feature uncertainty 2NOAA: Gulf of Mexico 'dead zone' predictions feature uncertainty 3Photograph of a living human brain is the overall winner of Wellcome Image Awards 2012 2
(Date:12/24/2014)... Diego, CA (PRWEB) December 23, 2014 ... where their Twitter followers can submit their #HolidayInTheLab ... themselves and their lab mates. , For those struggling ... lab mates, the Pipette.com Holiday in the Lab Contest ... Pipette.com Twitter followers to send pictures of ...
(Date:12/24/2014)... 23, 2014 Sigma-Aldrich Corporation (NASDAQ: ... period under the Hart-Scott-Rodino Antitrust Improvements Act (HSR ... December 22, 2014, thereby completing the U.S. HSR ... acquisition of the Company by Merck KGaA, Darmstadt, ... another condition to closing the transaction, which remains ...
(Date:12/22/2014)... ROCKVILLE, Md. , Dec. 22, 2014 ... MKT: SYN), a developer of pathogen-specific therapies ... focus on protecting the microbiome, today announced ... a Phase 1a clinical trial of SYN-004, ... the prevention of Clostridium difficile (C. ...
(Date:12/22/2014)... 22, 2014  ( www.competitivehealth.com ) — Competitive Health ... bill review and advocacy service, has signed an agreement ... Savings discount health services marketplace. 63% of ... than they expected to pay. As part of an ... WellCard Savings is pleased to offer medical bill review ...
Breaking Biology Technology:Major Pipette Distributor Pipette.com Announces their Holiday in the Lab Contest 2Acquisition of Sigma-Aldrich by Merck KGaA, Darmstadt, Germany, Receives U.S. Antitrust Clearance 2Acquisition of Sigma-Aldrich by Merck KGaA, Darmstadt, Germany, Receives U.S. Antitrust Clearance 3Synthetic Biologics Announces Positive Topline Results from Phase 1a Trial of SYN-004 for the Prevention of C. difficile Infection 2Synthetic Biologics Announces Positive Topline Results from Phase 1a Trial of SYN-004 for the Prevention of C. difficile Infection 3Synthetic Biologics Announces Positive Topline Results from Phase 1a Trial of SYN-004 for the Prevention of C. difficile Infection 4Synthetic Biologics Announces Positive Topline Results from Phase 1a Trial of SYN-004 for the Prevention of C. difficile Infection 5WellCard Savings Announces CoPatient Medical Bill Review Service for Members 2
... Graphene, a one-atom thick sheet of carbon ... "wonder material" that has taken scientific communities and ... material properties, such as high current-carrying capacity and ... components for semiconductor circuits and computers. Moreover, it ...
... improve photoelectrochemical cells. In the same way that plants ... use sunlight to drive chemical reactions that ultimately produce ... semi-conducting material such as cuprous oxide to provide the ... not expensive, the oxide is unstable if exposed to ...
... BioSpecifics Technologies Corp. (NASDAQ: BSTC ), a biopharmaceutical ... financial results for the first quarter ended March 31, 2011 ... reported a net income of $3.7 million or $0.59 per ... diluted basis. The Company anticipates that it will be profitable ...
Cached Biology Technology:Why graphene holds the key to the future 2Harnessing the energy of the Sun: New technique improves artificial photosynthesis 2BioSpecifics Technologies Corp. Reports First Quarter 2011 Financial Results 2BioSpecifics Technologies Corp. Reports First Quarter 2011 Financial Results 3BioSpecifics Technologies Corp. Reports First Quarter 2011 Financial Results 4BioSpecifics Technologies Corp. Reports First Quarter 2011 Financial Results 5BioSpecifics Technologies Corp. Reports First Quarter 2011 Financial Results 6BioSpecifics Technologies Corp. Reports First Quarter 2011 Financial Results 7BioSpecifics Technologies Corp. Reports First Quarter 2011 Financial Results 8
Immunogen: Human Respiratory Syncytial Virus (RSV) and Bovine Respiratory Syncytial Virus (BRSV) Fusion protein Storage: -20 C, Avoid Freeze/Thaw Cycles...
The DNA DipStick Kit is ideal for estimating nucleic acid concentrations and approximate yields. Works with ss- and ds-DNA, RNA, and oligonucleotides at concentrations as low as 0.1 ng/l....
Tris-Hepes kit of BG-163 & BG-165 (order number BG-166)...
... Synthetic peptide derived from the C-terminal ... Specificity: Reacts with the human ... Human Mouse (positive controls: WNT1-transfected HEK293 ... and mouse Mouse-1 cell lysates). ...
Biology Products: