Navigation Links
Mussel-inspired 'glue' for fetal membrane repair
Date:1/22/2010

A sealant inspired by mussels' ability to stick to surfaces under wet conditions has shown promise in the repair of defects in human fetal membranes, according to a recent Northwestern University study.

During pregnancy, defects -- ruptures or holes -- in the fetal membrane can lead to the leakage of amniotic fluid, resulting in premature labor or termination of the pregnancy. Although some defects do repair themselves naturally, no method currently exists to effectively repair those that don't. One idea is to find a biocompatible material to seal off the opening.

"We tested our mussel-inspired sealant on living fetal tissue and found it was both biocompatible and effective at sealing the tiny holes -- two features essential in such a material," said Phillip B. Messersmith, who was one of the study's leaders. He is professor of biomedical engineering at Northwestern's McCormick School of Engineering and Applied Science.

The findings are published online by the American Journal of Obstetrics & Gynecology.

The fetal membrane is the structure that surrounds the developing fetus. Defects in the membrane result either from incisions during endoscopic fetal surgeries used in the treatment of some birth defects or premature and spontaneous ruptures in the fetal sac.

Messersmith and colleagues from Belgium, Switzerland and Canada punched holes three millimeters wide into human fetal tissue in vitro to replicate the tiny holes found in fetal membrane defects. They then applied their sealant as well as other sealant candidates (such as medical-grade superglues) to the holes and analyzed fetal tissue cell death for each sealant. The mussel-inspired sealant had the best results in both bonding and toxicity.

The injectable sealant is a mixture of two different solutions that, when combined, form a sealant or gel in 10 to 20 seconds. One solution is a simple synthetic polymer containing DOPA, a key amino acid found in the sophisticated proteins that are essential to mussels' ability to adhere to wet surfaces, and the other is a catalyst. (Messersmith first developed the polymer in 2002.)

The foot of the common mussel (Mytilus edulis) produces a sticky glue that keeps the shelled organism anchored to rocks and other objects, allowing them to withstand the extreme pounding of waves. Chemical analysis of this natural, waterproof glue showed that the key to its adhesiveness is a family of unique proteins called mussel adhesive proteins, which contain a high concentration of DOPA (dihydroxyphenylalanine).

Messersmith and his colleagues currently are testing the mechanical qualities of the mussel-inspired sealant and plan to conduct in vivo experiments in animal models.


'/>"/>

Contact: Megan Fellman
fellman@northwestern.edu
847-491-3115
Northwestern University
Source:Eurekalert

Related biology news :

1. Glue inside the cell
2. Superglue from the sea
3. Super sticky barnacle glue cures like blood clots
4. Spider web glue spins society toward new biobased adhesives
5. Study reveals possible genetic risk for fetal alcohol disorders
6. Study suggests new way to screen infants for fetal alcohol syndrome
7. New study shows that fetal cells to treat Parkinsons disease may not function long term
8. Researchers block damage to fetal brain following maternal alcohol consumption
9. Alcohol consumption can cause too much cell death, fetal abnormalities
10. Chicks to give scientists clearer picture of fetal development
11. Fetal alcohol syndrome testing expands
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/15/2016)... 2016  A new partnership announced today will ... decisions in a fraction of the time it ... high-value life insurance policies to consumers without requiring ... Force Diagnostics, rapid testing (A1C, Cotinine and HIV) ... pressure, weight, pulse, BMI, and activity data) available ...
(Date:4/14/2016)... , April 14, 2016 ... Malware Detection, today announced the appointment of Eyal ... new role. Goldwerger,s leadership appointment comes at ... heels of the deployment of its platform at several ... biometric technology, which discerns unique cognitive and physiological factors, ...
(Date:3/31/2016)... 2016   LegacyXChange, ... "Company") LegacyXChange is excited to release its ... to be launched online site for trading 100% guaranteed ... will also provide potential shareholders a sense of the ... an industry that is notorious for fraud. The video ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... ... June 23, 2016 , ... ... the launch of the Supplyframe Design Lab . Located in Pasadena, Calif., ... the future of how hardware projects are designed, built and brought to market. ...
(Date:6/23/2016)... ... June 23, 2016 , ... In a new case report published today ... a patient who developed lymphedema after being treated for breast cancer benefitted from an ... paradigm for dealing with this debilitating, frequent side effect of cancer treatment. ...
(Date:6/23/2016)... June 23, 2016  Blueprint Bio, a company dedicated ... the medical community, has closed its Series A funding ... . "We have received a commitment from ... we need to meet our current goals," stated ... the runway to complete validation on the current projects ...
(Date:6/23/2016)... 2016 On Wednesday, June 22, 2016, ... 0.22%; the Dow Jones Industrial Average edged 0.27% lower to ... down 0.17%. Stock-Callers.com has initiated coverage on the following equities: ... (NASDAQ: NKTR ), Aralez Pharmaceuticals Inc. (NASDAQ: ... BIND ). Learn more about these stocks by accessing their ...
Breaking Biology Technology: