Navigation Links
Mussel goo inspires blood vessel glue
Date:12/11/2012

A University of British Columbia researcher has helped create a gel based on the mussel's knack for clinging to rocks, piers and boat hulls that can be painted onto the walls of blood vessels and stay put, forming a protective barrier with potentially life-saving implications.

Co-invented by Assistant Professor Christian Kastrup while a postdoctoral student at the Massachusetts Institute of Technology, the gel is similar to the amino acid that enables mussels to resist the power of churning water. The variant that Kastrup and his collaborators created, described in the current issue of the online journal PNAS Early Edition, can withstand the flow of blood through arteries and veins.

The gel's "sheer strength" could shore up weakened vessel walls at risk of rupturing much like the way putty can fill in dents in a wall, says Kastrup, a member of the Department of Biochemistry and Molecular Biology and the Michael Smith Laboratories.

By forming a stable barrier between blood and the vessel walls, the gel could also prevent the inflammation that typically occurs when a stent is inserted to widen a narrowed artery or vein; that inflammation often counteracts the opening of the vessel that the stent was intended to achieve.

The widest potential application would be preventing the rupture of blood vessel plaque. When a plaque ruptures, the resulting clot can block blood flow to the heart (triggering a heart attack) or the brain (triggering a stroke). Mice treated with a combination of the gel and an anti-inflammatory steroid had more stable plaque than a control group of untreated mice.

"By mimicking the mussel's ability to cling to objects, we created a substance that stays in place in a very dynamic environment with high flow velocities," says Kastrup, a member of UBC's Centre for Blood Research.


'/>"/>

Contact: Christian Kastrup
ckastrup@msl.ubc.ca
604-827-3749
University of British Columbia
Source:Eurekalert

Page: 1

Related biology news :

1. Silicone foul release coatings show promise to manage invasive mussels at water facilities
2. New book inspires children to protect dugongs
3. Human eye inspires clog-free ink jet printer invented by MU researcher
4. Origami inspires research into materials that self-assemble when exposed to light
5. Stanford scientists develop gene therapy approach to grow blood vessels in ischemic limbs
6. Scientists produce eye structures from human blood-derived stem cells
7. Blood on the menu
8. Glycemic index foods at breakfast can control blood sugar throughout the day
9. Detecting breast cancers fingerprint in a droplet of blood
10. Second-generation drug used for hypertension aids heart function independent of blood pressure
11. Changes in brains blood flow could cause brain freeze
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/28/2016)... 28, 2016 "The biometric ... 16.79%" The biometric system market is in the ... the near future. The biometric system market is expected ... at a CAGR of 16.79% between 2016 and 2022. ... biometric technology in smartphones, rising use of biometric technology ...
(Date:11/19/2016)... Securus Technologies, a leading provider of civil ... corrections and monitoring, announced today that it has offered ... an independent technology judge determine who has the largest ... telephone calling platform, and the best customer service. ... of what we do – which clearly is not ...
(Date:11/15/2016)... Research and Markets has announced the addition of the ... their offering. ... The global bioinformatics market ... 6.21 Billion in 2016, growing at a CAGR of 21.1% during ... is driven by the growing demand for nucleic acid and protein ...
Breaking Biology News(10 mins):
(Date:12/5/2016)... CHICAGO , December 5, 2016 ... report, "Cell Expansion Market, by Products (Consumable, Instruments, ... Applications (Regenerative Medicine and Stem Cell Research, Cancer, ... Research Institutes, Cell Banks) - Global Revenue, Trends, ... by Scalar Market Research, the global cell expansion ...
(Date:12/5/2016)... , Dec 5, 2016 Research ... report "DNA Sequencing - Technologies, Markets and Companies" ... ... report briefly reviews basics of human genome variations, development of ... are described as well as companies developing them. Various applications ...
(Date:12/4/2016)... and CAMBRIDGE, Mass. and ... Dec. 4, 2016 SystemOne, a company ... software platforms for the developing world, and Daktari ... a reality with its portable and ultrasensitive immunoassay-based ... a development and license agreement to integrate Daktari,s ...
(Date:12/2/2016)... -- CytRx Corporation (NASDAQ: CYTR ), a ... announced the appointment of Earl Warren Brien , ... healthcare investor, to its Board of Directors. ... strategic experience at the highest level," said Steven ... of the world,s leading orthopedic surgeons, Dr. Brien has ...
Breaking Biology Technology: