Navigation Links
Mussel goo inspires blood vessel glue
Date:12/11/2012

A University of British Columbia researcher has helped create a gel based on the mussel's knack for clinging to rocks, piers and boat hulls that can be painted onto the walls of blood vessels and stay put, forming a protective barrier with potentially life-saving implications.

Co-invented by Assistant Professor Christian Kastrup while a postdoctoral student at the Massachusetts Institute of Technology, the gel is similar to the amino acid that enables mussels to resist the power of churning water. The variant that Kastrup and his collaborators created, described in the current issue of the online journal PNAS Early Edition, can withstand the flow of blood through arteries and veins.

The gel's "sheer strength" could shore up weakened vessel walls at risk of rupturing much like the way putty can fill in dents in a wall, says Kastrup, a member of the Department of Biochemistry and Molecular Biology and the Michael Smith Laboratories.

By forming a stable barrier between blood and the vessel walls, the gel could also prevent the inflammation that typically occurs when a stent is inserted to widen a narrowed artery or vein; that inflammation often counteracts the opening of the vessel that the stent was intended to achieve.

The widest potential application would be preventing the rupture of blood vessel plaque. When a plaque ruptures, the resulting clot can block blood flow to the heart (triggering a heart attack) or the brain (triggering a stroke). Mice treated with a combination of the gel and an anti-inflammatory steroid had more stable plaque than a control group of untreated mice.

"By mimicking the mussel's ability to cling to objects, we created a substance that stays in place in a very dynamic environment with high flow velocities," says Kastrup, a member of UBC's Centre for Blood Research.


'/>"/>

Contact: Christian Kastrup
ckastrup@msl.ubc.ca
604-827-3749
University of British Columbia
Source:Eurekalert

Page: 1

Related biology news :

1. Silicone foul release coatings show promise to manage invasive mussels at water facilities
2. New book inspires children to protect dugongs
3. Human eye inspires clog-free ink jet printer invented by MU researcher
4. Origami inspires research into materials that self-assemble when exposed to light
5. Stanford scientists develop gene therapy approach to grow blood vessels in ischemic limbs
6. Scientists produce eye structures from human blood-derived stem cells
7. Blood on the menu
8. Glycemic index foods at breakfast can control blood sugar throughout the day
9. Detecting breast cancers fingerprint in a droplet of blood
10. Second-generation drug used for hypertension aids heart function independent of blood pressure
11. Changes in brains blood flow could cause brain freeze
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/5/2017)... YORK , April 5, 2017 Today ... is announcing that the server component of the HYPR ... known for providing the end-to-end security architecture that empowers ... HYPR has already secured over 15 million ... makers including manufacturers of connected home product suites and ...
(Date:3/30/2017)... -- On April 6-7, 2017, Sequencing.com will host the world,s ... at Microsoft,s headquarters in Redmond, Washington ... health and wellness apps that provide a unique, personalized ... is the first hackathon for personal genomics and the ... the genomics, tech and health industries are sending teams ...
(Date:3/28/2017)... -- The report "Video Surveillance Market by ... Devices), Software (Video Analytics, VMS), and Service (VSaaS, Installation ... 2022", published by MarketsandMarkets, the market was valued at ... reach USD 75.64 Billion by 2022, at a CAGR ... considered for the study is 2016 and the forecast ...
Breaking Biology News(10 mins):
(Date:8/16/2017)... Ca (PRWEB) , ... August 16, 2017 , ... ... by changing into a different cell type. Many treatments for specific cancers, such ... prominent example of targeted treatment is androgen deprivation therapy for advanced prostate cancer. ...
(Date:8/16/2017)... ... 16, 2017 , ... Today, 3Bar Biologics Inc ., ... in funding from an impressive group of investors, including Rev1 Ventures, Maumee Ventures, ... this investment, 3Bar is broadening availability of its groundbreaking offering that uses naturally ...
(Date:8/16/2017)... , Aug. 16, 2017  This year,s edition of the Inc. 5000 ... life sciences workforce solutions, has made the list for the third year ... the nation,s fastest-growing private companies based on a set of quantitative metrics. ... includes the fastest-growing companies in the Bay State . ... Inc. 5000 ...
(Date:8/15/2017)... 2017 After spending the past two years building a ... collection, GeneFo now offers this platform to healthcare stakeholders (hospitals, foundations, ... adherence, and data collection vis a vis their members, under their ... launch of this offer. ... ...
Breaking Biology Technology: