Navigation Links
Music is the engine of new U-M lab-on-a-chip device
Date:7/22/2009

ANN ARBOR, Mich.---Music, rather than electromechanical valves, can drive experimental samples through a lab-on-a-chip in a new system developed at the University of Michigan. This development could significantly simplify the process of conducting experiments in microfluidic devices.

A paper on the research will be published online in the Proceedings of the National Academy of Sciences the week of July 20.

A lab-on-a-chip, or microfluidic device, integrates multiple laboratory functions onto one chip just millimeters or centimeters in size. The devices allow researchers to experiment on tiny sample sizes, and also to simultaneously perform multiple experiments on the same material. There is hope that they could lead to instant home tests for illnesses, food contaminants and toxic gases, among other advances.

To do an experiment in a microfluidic device today, researchers often use dozens of air hoses, valves and electrical connections between the chip and a computer to move, mix and split pin-prick drops of fluid in the device's microscopic channels and divots.

"You quickly lose the advantage of a small microfluidic system," said Mark Burns, professor and chair of the Department of Chemical Engineering and a professor in the Department of Biomedical Engineering.

"You'd really like to see something the size of an iPhone that you could sneeze onto and it would tell you if you have the flu. What hasn't been developed for such a small system is the pneumatics---the mechanisms for moving chemicals and samples around on the device."

The U-M researchers use sound waves to drive a unique pneumatic system that does not require electromechanical valves. Instead, musical notes produce the air pressure to control droplets in the device. The U-M system requires only one "off-chip" connection.

"This system is a lot like fiberoptics, or cable television. Nobody's dragging 200 separate wires all over your house to power all those channels," Burns said. "There's one cable signal that gets decoded."

The system developed by Burns, chemical engineering doctoral student Sean Langelier, and their collaborators replaces these air hoses, valves and electrical connections with what are called resonance cavities. The resonance cavities are tubes of specific lengths that amplify particular musical notes.

These cavities are connected on one end to channels in the microfluidic device, and on the other end to a speaker, which is connected to a computer. The computer generates the notes, or chords. The resonance cavities amplify those notes and the sound waves push air through a hole in the resonance cavity to their assigned channel. The air then nudges the droplets in the microfluidic device along.

"Each resonance cavity on the device is designed to amplify a specific tone and turn it into a useful pressure," Langelier said. "If I play one note, one droplet moves. If I play a three-note chord, three move, and so on. And because the cavities don't communicate with each other, I can vary the strength of the individual notes within the chords to move a given drop faster or slower."

Burns describes the set-up as the reverse of a bell choir. Rather than ringing a bell to create sound waves in the air, which are heard as music, this system uses music to create sound waves in the device, which in turn, move the experimental droplets.

"I think this is a very clever system," Burns said. "It's a way to make the connections between the microfluidic world and the real world much simpler."

The new system is still external to the chip, but the researchers are working to make it smaller and incorporate it on a microfluidic device. That would be a step closer to a smartphone-sized home flu test.


'/>"/>

Contact: Nicole Casal Moore
ncmoore@umich.edu
734-647-1838
University of Michigan
Source:Eurekalert

Related biology news :

1. The neurobiology of musicality related to the intrinsic attachment behavior?
2. Some vocal-mimicking animals, particularly parrots, can move to a musical beat
3. Brain music
4. Musicians have biological advantage in identifying emotion in sound
5. American Library Association names NJIT prof’s Whale Music book a top ten
6. Research shows that time invested in practicing pays off for young musicians
7. Genetically engineered mice yield clues to knocking out cancer
8. Kelvin Lee winner of Biochemical Engineering Journal Young Investigator Award
9. Engineering innovative solutions for 21st century medicine
10. Engineered pig stem cells bridge the mouse-human gap
11. Researchers engineer metabolic pathway in mice to prevent diet-induced obesity
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/23/2017)... ARMONK, N.Y. , Aug. 23, 2017  The general public,s help ... the human microbiome—the bacteria that live in and on the human body ... ... bacteria in the human microbiome, starting with the gut. The project's goal ... in disease. Photo credit: IBM ...
(Date:7/20/2017)... , July 20, 2017 Delta (NYSE: DAL ... board any Delta aircraft at Reagan Washington National Airport (DCA). ... Delta launches biometrics to ... Delta,s biometric ... Sky Club is now integrated into the boarding process to allow ...
(Date:6/23/2017)... ITHACA, N.Y. , June 23, 2017  IBM ... in dairy research, today announced a new collaboration using ... the chances that the global milk supply is impacted ... project, Cornell University has become the newest academic institution ... Chain, a food safety initiative that includes IBM Research, ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... , ... October 11, 2017 , ... ... announced today it will be hosting a Webinar titled, “Pathology is going digital. ... Associates , on digital pathology adoption best practices and how Proscia improves lab ...
(Date:10/11/2017)... , ... October 11, 2017 , ... ... (FDA) has granted orphan drug designation to SBT-100, its novel anti-STAT3 (Signal Transducer ... treatment of osteosarcoma. SBT-100 is able to cross the cell membrane and bind ...
(Date:10/10/2017)... DALLAS , Oct. 10, 2017 International research firm ... IoT Strategy, will speak at the TMA 2017 Annual Meeting , ... key trends in the residential home security market and how smart safety ... ... "The ...
(Date:10/9/2017)... FL (PRWEB) , ... October 09, 2017 , ... The ... scheduled to broadcast first quarter 2018. American Farmer airs Tuesdays at 8:30aET on RFD-TV. ... industry is faced with the challenge of how to continue to feed a growing ...
Breaking Biology Technology: