Navigation Links
Mushroom-derived compound lengthens survival in dogs with cancer, Penn Vet study finds
Date:9/10/2012

PHILADELPHIA Dogs with hemangiosarcoma that were treated with a compound derived from the Coriolus versicolor mushroom had the longest survival times ever reported for dogs with the disease. These promising findings offer hope that the compound may one day offer cancer patients human and canine alike a viable alternative or complementary treatment to traditional chemotherapies.

The study was conducted by two University of Pennsylvania School of Veterinary Medicine faculty. Dorothy Cimino Brown is professor and chair of the Department of Clinical Studies and director of the Veterinary Clinical Investigation Center. Jennifer Reetz is an attending radiologist in the Department of Clinical Studies. They published their findings in an open-access article in the journal Evidence-Based Complementary and Alternative Medicine.

The Coriolus versicolor mushroom, known commonly as the Yunzhi mushroom, has been used in traditional Chinese medicine for more than 2,000 years. The compound in the mushroom that is believed to have immune-boosting properties is polysaccharopeptide, or PSP. In the last two decades, some studies have suggested that PSP also has a tumor-fighting effect.

"There have been a series of studies looking at groups of people with cancer," Cimino Brown said. "The issue with those studies is that they weren't necessarily measuring what most people would think is the most clinically important result, which is, do people taking PSP live longer?"

To address this critical question, Cimino Brown and Reetz pursued a study in dogs with naturally occurring hemangiosarcoma, an aggressive, invasive cancer that arises from the blood cells and typically affects the spleen. It commonly strikes golden retrievers and German shepherds.

Fifteen dogs that had been diagnosed with hemangiosarcoma participated in the trial. Divided into three groups of five, each group received a different dose 25, 50 or 100 mg/kg/day of
'/>"/>

Contact: Katherine Unger Baillie
kbaillie@upenn.edu
215-898-9194
University of Pennsylvania
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Compound discovered that boosts effect of vaccines against HIV and flu
2. MMV develops framework to assess risk of resistance for antimalarial compounds
3. Compounds shown to thwart stubborn pathogens social propensity
4. University of Albertas designer compounds inhibit prion infection
5. Scripps Research scientists show potent new compound virtually eliminates HIV in cell culture
6. Poisoning from industrial compounds can cause similar effects to ALS
7. New compound holds promise for treating Duchenne MD, other inherited diseases
8. Nonstoichiometric Compounds V - An ECI Conference Series
9. New drug-screening method yields long-sought anti-HIV compounds
10. Dont feel like exercise? Scientists find compound that may help you work out harder
11. Nuisance seaweed found to produce compounds with biomedical potential
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... CHICAGO , Aug. 27, 2014 /PRNewswire-iReach/ -- The ... hosting the 36 th Annual International Conference (EMBC,14), ... and Towers in Chicago, Illinois , ... than 2,500 global leaders, students, and industry professionals in ... Logo - http://photos.prnewswire.com/prnh/20140827/140333 ...
(Date:8/27/2014)... But every creature is a baby once. , A ... 24 very young dinosaurs and one older individual is ... caretaker, according to a new study by University of ... Dodson led the work, collaborating with researchers from China,s ... held. Hedrick is a doctoral student in the School ...
(Date:8/27/2014)... is available in German . ... the most common inherited disease affecting the peripheral nervous ... Max Planck Institute of Experimental Medicine and University Medical ... cells is impaired in rats with the disease. These ... known as myelin, which facilitates the rapid transfer of ...
Breaking Biology News(10 mins):Global Leaders In Science, Medicine, And Engineering Gather For The 36th Annual International Conference Of The IEEE Engineering In Medicine And Biology Society, August 26-30 In Chicago 2Global Leaders In Science, Medicine, And Engineering Gather For The 36th Annual International Conference Of The IEEE Engineering In Medicine And Biology Society, August 26-30 In Chicago 3Penn paleontologists describe a possible dinosaur nest and young 'babysitter' 2Penn paleontologists describe a possible dinosaur nest and young 'babysitter' 3Potential therapy for incurable Charcot-Marie-Tooth disease 2
... canary in the coal mine, penguins are sounding ... world,s oceans, and the culprit isn,t only climate ... Oil pollution, depletion of fisheries and rampant ... penguin species, along with Earth,s warming climate, are ...
... current standard practice of giving infants and children 100 ... deprivation may actually inflict additional harm, researchers at UT ... by oxygen deprivation, known as hypoxic-ischemic brain injury, is ... long-term neurological damage among infants and children. This can ...
... Twelve investigators have received grants totaling $5 million ... of food allergy, a significant public health concern. ... is funded by the National Institute of Allergy ... Institutes of Health, and two advocacy groups, the ...
Cached Biology News:Penguins setting off sirens over health of world's oceans 2Penguins setting off sirens over health of world's oceans 3Penguins setting off sirens over health of world's oceans 4Resuscitation technique after brain injury may do more harm than good 2NIAID announces grants to stimulate food allergy research 2NIAID announces grants to stimulate food allergy research 3
(Date:8/27/2014)... , Aug. 27, 2014  A novel ... to help physicians better identify early-stage disease, when ... disability, according to a new study in The ... Diagnostics (NYSE: DGX ) and other ... 14-3-3eta protein outperformed conventional antibody-serum testing, including rheumatoid ...
(Date:8/27/2014)... “We are honored to be named to this ... of Radiant Sage. “We are offering truly ground-breaking clinical ... market to a different level. We are enabling ... and effectively manage the massive amounts of medical imaging ... read by trained physicians. Being recognized by technology industry ...
(Date:8/27/2014)... Aug. 27, 2014 Guggenheim Securities, the investment ... announced the hiring of veteran equity analyst Charles "Tony" ... Mr. Butler will focus on the biotech/biopharma sector. ... wealth of experience and a broad network of relationships ... Managing Director and Head of Equities at Guggenheim Securities. ...
(Date:8/27/2014)... 2014 Reportbuyer.com has added a new ... - A Rational View https://www.reportbuyer.com/product/1595336/The-Graphene-Opportunity---A-Rational-View.html ... A similar amount of hype currently surrounds ... microelectronics to water treatment, but is graphene the ... the Graphene Opportunity Report, authored by Tim ...
Breaking Biology Technology:Novel Biomarker Detects Early Rheumatoid Arthritis Better than Conventional Methods Alone, According to Journal of Rheumatology Study 2Novel Biomarker Detects Early Rheumatoid Arthritis Better than Conventional Methods Alone, According to Journal of Rheumatology Study 3Novel Biomarker Detects Early Rheumatoid Arthritis Better than Conventional Methods Alone, According to Journal of Rheumatology Study 4Radiant Sage Named to CIOReview List of 100 Most Promising Technology Companies 2Guggenheim Securities Hires Analyst Charles "Tony" Butler to Expand Healthcare Coverage 2The Graphene Opportunity - A Rational View 2The Graphene Opportunity - A Rational View 3The Graphene Opportunity - A Rational View 4
... Sangamo BioSciences, Inc. (Nasdaq: SGMO ) today announced that the ... 28, 2010 , after the market closes. The press release will be followed ... open to the public via telephone and webcast. During the conference call, the ... , , ...
... EXTON, Pa. , July 21 ViroPharma Incorporated,s (Nasdaq: VPHM ... Wednesday, July 28, 2010 before the open of the U.S. financial markets. , ... The company will host a conference call and live ... the conference call, ViroPharma management will discuss the 2010 second quarter financial results and ...
... RESEARCH TRIANGLE PARK, N.C. , July 21 Chimerix, ... it has expanded its clinical management team with the appointment of ... and Herve Mommeja-Marin, MD, as Vice President of Clinical Research.   ... In these ...
Cached Biology Technology:Sangamo BioSciences Announces Second Quarter 2010 Conference Call and Webcast 2ViroPharma to Release 2010 Second Quarter Financial Results on July 28, 2010 2Chimerix Appoints Two New Vice Presidents to Clinical Management Team 2Chimerix Appoints Two New Vice Presidents to Clinical Management Team 3
... a commonly used technique for studying protein ... electrophoresed on SDS-PAGE and transferred to a ... they are probed with specific antibodies. Unlike ... of Southern and Northern blots, it has ...
... Basic Package Superior Protein Detection and ... ProXPRESS 2D Proteomic Imaging System is a ... proteomic and general life science research applications. ... use of all dyes in the UV ...
... our Regulatory Edition of Molecular Imaging (MI) ... for life science research and drug discovery ... with U.S. Food and Drug Administrations Code ... Electronic Records; Electronic Signatures [21 CFR Part ...
... Neutralizing synthetic peptide for OPA1-01009, OPEP-01009 is a 16 amino ... human DNA fragmentation factor (DFF). The sequence of this ... P - K - S - V - K - ... S - P - R - K(18). This ...
Biology Products: