Navigation Links
Muscle mass: Scientists identify novel mode of transcriptional regulation during myogenesis
Date:8/17/2007

In an upcoming issue of G&D, Drs. Maria Divina Deato and Robert Tjian (HHMI, UC Berkeley) reveal that the formation of an alternative transcriptional core promoter complex directs cell-type specific differentiation during myogenesis. The article uncovers a whole new level of transcriptional control of terminal cell differentiation, and will be published online ahead of its September 1 print date at www.genesdev.org.

For nearly 30 years, we have assumed that the basal transcription machinery, particularly the highly conserved TBP and TFIID complex, would be invariant and universal for all cell types in eukaryotes. It seems that this simplistic model will need to be revised with significant implications for mechanisms controlling multi-cellular differentiation, explains Dr. Tjian.

Skeletal muscle differentiation, or myogenesis, involves a multi-step transition from muscle precursor cells (myoblasts) to myotubes that ultimately comprise the contractile myofibers of the muscle tissue. Drs. Deato and Tjian show that during myogenesis, a component of the canonical transcription initiation machinery a multi-subunit transcription factor called TFIID is disassembled and replaced with an alternative core promoter recognition complex. The researchers determined that this alternative complex contains both TAF3 and TRF3, and is required for successful myogenesis.


'/>"/>
Contact: Heather Cosel
coselpie@cshl.edu
Cold Spring Harbor Laboratory
Source:Eurekalert

Page: 1

Related biology news :

1. Muscle-targeted gene therapy reverses rare muscular dystrophy in mice
2. X-Ray Beams And Fruit Fly Flight Simulator Aid Scientists View Of Muscle Power
3. Heart repair gets new muscle
4. Young Blood Revives Aging Muscles, Stanford Researchers Find
5. Small worm yields big clue on muscle receptor action
6. New complete muscle grown in the lab
7. Spiders help scientists discover how muscles relax
8. Cant serve an ace? Could be muscle fatigue
9. Lance Armstrong through a physiological lens: hard training boosts muscle power 8%
10. Muscle repair: Making a good system better, faster; implications for aging, disease
11. Gene therapy for muscular dystrophy fixes frail muscle cells in animal model, Stanford study finds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/6/2017)... 2017  Privately-held CalciMedica, Inc., announced that it ... of a novel calcium release-activated calcium (CRAC) channel ... Acute pancreatitis, sudden painful inflammation of ... can be very serious.  In severe cases it can ... hospital stays, time in the ICU and substantial ...
(Date:1/4/2017)... LAS VEGAS , Jan. 4, 2017 /PRNewswire/ ... in performance biometric sensor technology, today announced the ... Benchmark™ sensor systems, the highly-accurate biometric sensor ... ® biometric technology, experience and expertise. The ... of Benchmark designed specifically for hearables, and Benchmark ...
(Date:12/20/2016)... -- The rising popularity of mobility services such ... significant interest in keyless access systems. Following the ... (BLE), biometrics and near-field communication (NFC) are poised ... technologies in the automotive industry. This evolution from ... opens the market to specialist companies such as ...
Breaking Biology News(10 mins):
(Date:1/18/2017)... India , January 18, 2017 According to a ... (Cancer Diagnosis, Neuroscience, Cytology, Infectious Disease), & End User (Molecular Diagnostic Laboratories, Academic ... is expected to reach USD 739.9 Million by 2021 from USD 557.1 Million ... Continue Reading ... MarketsandMarkets Logo ...
(Date:1/18/2017)... ... January 18, 2017 , ... ... Ops Executives 2017 in its continued commitment to the advancement of the clinical ... discuss current issues related to clinical trial planning and management. , As ...
(Date:1/18/2017)... ... 2017 , ... MYOLYN, which creates medical technology for people ... to the FDA, requesting clearance of the MyoCycle Home and the MyoCycle Pro ... , The submission marks a major milestone for the technology startup. MYOLYN spun ...
(Date:1/18/2017)... , ... January 18, 2017 , ... ... publishing of the latest paper by its Science Editor, Dr. Elisabeth Bik, in ... voor Medische Microbiologie). Dr. Bik joined uBiome in October 2016 from her previous ...
Breaking Biology Technology: