Navigation Links
Muscle loss finding may one day save physiques
Date:2/12/2010

SAN ANTONIO (Feb. 12, 2010) Hey guys, remember the muscle shirts we wore in our teens and 20s? After the age of 40 that meager part of our wardrobes usually is obsolete. Yes, at the big 4-0 we begin to lose muscle, and by age 80 up to a third of it may be gone. It's an inevitable process of aging called sarcopenia.

Why does sarcopenia happen and can it be stopped? A study conducted in mice with accelerated muscle loss at The University of Texas Health Science Center at San Antonio provides this insight: Less protection from antioxidants and more damage from oxidative stress results in impairment to cells' energy centers, which slowly leads to death of muscle cells.

A team directed by Holly Van Remmen, Ph.D., associate professor with the university's Barshop Institute for Longevity and Aging Studies and the Department of Cellular and Structural Biology, found that without a certain antioxidant enzyme to balance the formation of harmful reactive oxygen species (ROS), cellular energy centers called mitochondria fail to work properly. The mitochondria even add to the spate of ROS molecules and release factors leading to cell death.

"The impaired function of mitochondria also has a detrimental effect on the way motor neurons 'talk' to the muscle to achieve muscle contraction," Dr. Van Remmen said. "This interaction occurs at a specialized synapse where the nerve and muscle come in close contact." This key structure is called the neuromuscular junction, she said.

Smaller and weaker muscles

Youngmok C. Jang, Ph.D., a leading author in the study, investigated mice that were genetically engineered to lack an antioxidant enzyme called copper-zinc superoxide dismutase. He compared mitochondria from these mice and normal mice and found reduced function of the energy centers in the enzyme-deficient mice. This contributed to more cell death and muscle atrophy in the rodents. "As a result, their muscles were a lot smaller and weaker," Dr. Van Remmen said.

Insights gleaned about muscle loss can help scientists better understand other neuromuscular diseases such as amyotrophic lateral sclerosis (Lou Gehrig's disease). "Age-related muscle atrophy is a complex process and involves multiple systems," Dr. Van Remmen said. "There are, however, common mechanisms occurring in sarcopenia and other neuromuscular diseases. By understanding the mechanisms underlying age-related muscle atrophy and alterations at the neuromuscular junction, we should be able to gain insight that will help us to discover new therapeutic interventions."

If a muscle-preserving therapy is one day developed, future generations of young men will be able to keep their muscle shirts a bit longer.


'/>"/>

Contact: Will Sansom
sansom@uthscsa.edu
210-567-2579
University of Texas Health Science Center at San Antonio
Source:Eurekalert

Related biology news :

1. Muscle mass: Scientists identify novel mode of transcriptional regulation during myogenesis
2. Pittsburgh scientists identify human source of stem cells with potential to repair muscle
3. Massive microRNA scan uncovers leads to treating muscle degeneration
4. Mechanism for regulation of growth and differentiation of adult muscle stem cells is revealed
5. How molecular muscles help cells divide
6. An ambulance man for muscle damage
7. Stem-cell transplantation improves muscles in MD animal model, UT Southwestern researchers report
8. Long-term use of mechanical ventilation contributes to the deterioration of human diaphragm muscle
9. RING finger protein 5 may guide treatment for muscle disease in older adults
10. Ibuprofen or acetaminophen in long-term resistance training increases muscle mass/strength
11. Pitt and University of Chicago researchers uncover process behind heart muscle contraction
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/30/2017)... ANGELES , March 30, 2017  On April ... Hack the Genome hackathon at Microsoft,s ... exciting two-day competition will focus on developing health and ... Hack the Genome is the ... been tremendous. The world,s largest companies in the genomics, ...
(Date:3/27/2017)... CENTRE, N.Y. , March 27, 2017 /PRNewswire-USNewswire/ ... Healthcare Information and Management Systems Society (HIMSS) Analytics ... Outpatient EMR Adoption Model sm . In addition, ... 12% of U.S. hospitals using an electronic medical ... CHS for its high level of EMR usage ...
(Date:3/22/2017)... 21, 2017   Neurotechnology , a provider ... today announced the release of the SentiVeillance ... improved facial recognition using up to 10 surveillance, ... computer. The new version uses deep neural-network-based facial ... it utilizes a Graphing Processing Unit (GPU) for ...
Breaking Biology News(10 mins):
(Date:6/20/2017)... 2017  Kibow Biotech Inc., a pioneer in developing ... of a new patent covering a unique method for ... Patent and Trademark Office on May 23 rd ... of Bio award in 2014 in San ... approaches to chronic disease. Renadyl™, the first and only ...
(Date:6/19/2017)... NJ (PRWEB) , ... June 19, 2017 , ... ... for overseeing all service activities supporting EDETEK’s products including training, implementation, support, and ... experience to his new role. He has previously held leadership roles for service ...
(Date:6/16/2017)... ... June 16, 2017 , ... Cognition Corporation ... announced two more sessions of its “From the Helm” Webinar Series. , ... of online templates for design control exercises. Led by David Cronin, Cognition’s CEO, ...
(Date:6/15/2017)... ... June 15, 2017 , ... ... secured a Series B round of financing in the amount of $6 million. ... private investors participated in the round. , The Series B funding will enable ...
Breaking Biology Technology: