Navigation Links
Muscle loss finding may one day save physiques
Date:2/12/2010

SAN ANTONIO (Feb. 12, 2010) Hey guys, remember the muscle shirts we wore in our teens and 20s? After the age of 40 that meager part of our wardrobes usually is obsolete. Yes, at the big 4-0 we begin to lose muscle, and by age 80 up to a third of it may be gone. It's an inevitable process of aging called sarcopenia.

Why does sarcopenia happen and can it be stopped? A study conducted in mice with accelerated muscle loss at The University of Texas Health Science Center at San Antonio provides this insight: Less protection from antioxidants and more damage from oxidative stress results in impairment to cells' energy centers, which slowly leads to death of muscle cells.

A team directed by Holly Van Remmen, Ph.D., associate professor with the university's Barshop Institute for Longevity and Aging Studies and the Department of Cellular and Structural Biology, found that without a certain antioxidant enzyme to balance the formation of harmful reactive oxygen species (ROS), cellular energy centers called mitochondria fail to work properly. The mitochondria even add to the spate of ROS molecules and release factors leading to cell death.

"The impaired function of mitochondria also has a detrimental effect on the way motor neurons 'talk' to the muscle to achieve muscle contraction," Dr. Van Remmen said. "This interaction occurs at a specialized synapse where the nerve and muscle come in close contact." This key structure is called the neuromuscular junction, she said.

Smaller and weaker muscles

Youngmok C. Jang, Ph.D., a leading author in the study, investigated mice that were genetically engineered to lack an antioxidant enzyme called copper-zinc superoxide dismutase. He compared mitochondria from these mice and normal mice and found reduced function of the energy centers in the enzyme-deficient mice. This contributed to more cell death and muscle atrophy in the rodents. "As a result, their muscles were a lot smaller and weaker," Dr. Van Remmen said.

Insights gleaned about muscle loss can help scientists better understand other neuromuscular diseases such as amyotrophic lateral sclerosis (Lou Gehrig's disease). "Age-related muscle atrophy is a complex process and involves multiple systems," Dr. Van Remmen said. "There are, however, common mechanisms occurring in sarcopenia and other neuromuscular diseases. By understanding the mechanisms underlying age-related muscle atrophy and alterations at the neuromuscular junction, we should be able to gain insight that will help us to discover new therapeutic interventions."

If a muscle-preserving therapy is one day developed, future generations of young men will be able to keep their muscle shirts a bit longer.


'/>"/>

Contact: Will Sansom
sansom@uthscsa.edu
210-567-2579
University of Texas Health Science Center at San Antonio
Source:Eurekalert

Related biology news :

1. Muscle mass: Scientists identify novel mode of transcriptional regulation during myogenesis
2. Pittsburgh scientists identify human source of stem cells with potential to repair muscle
3. Massive microRNA scan uncovers leads to treating muscle degeneration
4. Mechanism for regulation of growth and differentiation of adult muscle stem cells is revealed
5. How molecular muscles help cells divide
6. An ambulance man for muscle damage
7. Stem-cell transplantation improves muscles in MD animal model, UT Southwestern researchers report
8. Long-term use of mechanical ventilation contributes to the deterioration of human diaphragm muscle
9. RING finger protein 5 may guide treatment for muscle disease in older adults
10. Ibuprofen or acetaminophen in long-term resistance training increases muscle mass/strength
11. Pitt and University of Chicago researchers uncover process behind heart muscle contraction
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/28/2016)... (NASDAQ: SYNA ), a leading developer of human interface solutions, ... 2015. --> --> Net ... compared to the comparable quarter last year to $470.5 million. Net ... or $0.93 per diluted share. --> ... fiscal 2016 grew 9 percent over the prior year period to ...
(Date:1/22/2016)... 2016 http://www.researchandmarkets.com/research/4lmf2s/global_behavioral ... the  "Global Behavioral Biometric Market 2016-2020" ... http://www.researchandmarkets.com/research/4lmf2s/global_behavioral ) has announced the ... Market 2016-2020"  report to their offering. ... http://www.researchandmarkets.com/research/4lmf2s/global_behavioral ) has announced the addition ...
(Date:1/20/2016)... Minn. , Jan. 20, 2016   MedNet ... supports the entire spectrum of clinical research, is pleased ... 2015. MedNet,s significant achievements are the result of the ... iMedNet eClinical , it,s comprehensive, easy-to-use ... --> --> Key MedNet growth achievements ...
Breaking Biology News(10 mins):
(Date:2/8/2016)... (PRWEB) , ... February 08, 2016 , ... ... Board of Directors. Todorow is the Executive Vice President for Corporate Services and ... Todorow oversees Finance, Accounts Payable, Payroll, Billing Operations, Treasury, Managed Care Contracting, Supply ...
(Date:2/8/2016)... ... 08, 2016 , ... Bulk food product inspection systems are ... stages of the production process. Despite frequently inspecting loose product prior to packaging, ... such as sacks of dry powders. , Mettler-Toledo Product Inspection's brand-new white paper ...
(Date:2/8/2016)... the development of future natural products for crop protection. In ... center in Israel and invests substantial ... has a variety of products adapted to regional needs, ... than 35 counties worldwide. ... Gold ® is used to control a broad spectrum ...
(Date:2/6/2016)... , ... February 06, 2016 , ... The Center for ... for middle and high school teachers on Wednesday February 10, 2016. This Bite ... the Smithsonian-Mason School of Conservation, located at 1500 Remount Road in Front Royal, VA ...
Breaking Biology Technology: