Navigation Links
Muscle-invasive and non-muscle invasive bladder cancers arise from different stem cells
Date:12/17/2013

Bladder cancer will kill upward of 170,000 people worldwide this year, but bladder cancer isn't fatal in the bladder. Instead, in order to be fatal the disease must metastasize to faraway sites. The question has been this: does localized, non-muscle invasive (NMI) bladder cancer eventually become the more dangerous, muscle-invasive (MI) form of the disease, or are NMI and MI bladder cancers genetically distinct from the start?

A University of Colorado Cancer Center study published today in the journal Stem Cells shows it's the latter: the progenitor cells that create MI bladder cancer are different than the progenitor cells that create NMI bladder cancer. Though these two cancers grow at the same site, they are different diseases.

"This work provides an important new perspective on how we look at bladder cancer biology," says Dan Theodorescu, MD, PhD, director of the University of Colorado Cancer Center and the study's senior author.

The group including first author Garrett Dancik, PhD, genetically profiled two cell types that could give rise to bladder cancer the basal and umbrella layers of the normal bladder lining (urothelium) to discover the gene signatures specific to each of these cell populations.

Then the group compared these gene signatures to human bladder cancer samples. The tumor samples were distinct: those with the signature of umbrella cells were likely to be lower stage and patients eventually had favorable outcomes; tumors with the signatures of basal layer cells were likely to be higher stage and patients eventually had worse outcomes.

"We saw a fairly stark difference between these tumor types: those with basal signatures were distinctly more aggressive than those with umbrella signatures," Theodorescu says. In fact, these signatures predicted tumor stage and patient survival better than many existing prognostic markers.

"Our results suggests that NMI cells arise from non-basal cells, whereas MI tumors arise from basal cells," Theodorescu says.

"This may be an important biomarker for prognosis," Theodorescu says. "With additional testing, we could use the signature to predict how aggressive a bladder cancer is likely to be. Knowing the risk can help doctors and patients make informed treatment decisions."


'/>"/>

Contact: Garth Sundem
garth.sundem@ucdenver.edu
University of Colorado Denver
Source:Eurekalert  

Related biology news :

1. Peaceful bumblebee becomes invasive
2. USF researchers show invasive sparrows immune cells sharpen as they spread
3. Edited RNA + invasive DNA add individuality
4. Angel or demon: Can a potentially invasive plant bring a positive influence to a region?
5. Adaptability to local climate helps invasive species thrive
6. Texas Invasive Species Program established at UT Austin
7. Non-invasive first trimester blood test reliably detects Downs syndrome
8. Biomarker identification may lead to new noninvasive test for colorectal cancer detection
9. Researchers calculate the global highways of invasive marine species
10. New scientific studies reveal Midwestern frogs decline, mammal populations altered by invasive plant
11. Dirty dozen invasive species threaten UK
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Muscle-invasive and non-muscle invasive bladder cancers arise from different stem cells
(Date:4/26/2016)... India and LONDON ... Infosys Finacle, part of EdgeVerve Systems, a product ... and Onegini today announced a partnership to integrate ... solutions.      (Logo: http://photos.prnewswire.com/prnh/20151104/283829LOGO ... to provide their customers enhanced security to access ...
(Date:4/15/2016)... , April 15, 2016 ... the,  "Global Gait Biometrics Market 2016-2020,"  report to ... http://photos.prnewswire.com/prnh/20160330/349511LOGO ) , ,The global gait biometrics ... of 13.98% during the period 2016-2020. ... angles, which can be used to compute factors ...
(Date:3/31/2016)... March 31, 2016  Genomics firm Nabsys has completed ... Barrett Bready , M.D., who returned to the ... original technical leadership team, including Chief Technology Officer, ... Development, Steve Nurnberg and Vice President of Software and ... company. Dr. Bready served as CEO of ...
Breaking Biology News(10 mins):
(Date:5/4/2016)... ... May 04, 2016 , ... The Children’s Tumor Foundation announced its annual ... to grow on nerves throughout the body. It affects 1 in 3,000 people of ... held during the month of May, as well as online activities, Neurofibromatosis Awareness Month ...
(Date:5/4/2016)... ... May 04, 2016 , ... PBI-Gordon Corporation is pleased to announce ... , Doug began his career at PBI-Gordon in February 1988, after finishing his masters ... of roles, ranging from customer service to national product manager, to helping develop, name ...
(Date:5/3/2016)... 2016 The report "Biochips ... Gene Expression) Lab-on-a-chip (IVD & POC, Proteomics), ... Centers), Fabrication Technology (Microarrays, Microfluidics) - Forecast ... is expected to reach USD 17.75 Billion ... 2015, growing at a CAGR of 18.4% ...
(Date:5/3/2016)... ... 03, 2016 , ... In a list published by the Boston Business Journal, ... private companies; a small percentage of the state's 615,000+ small businesses. The list examined ... in revenue from 2012 to 2015. , As this award comes on ...
Breaking Biology Technology: