Navigation Links
Muscle atrophy through thick but not thin
Date:6/8/2009

During desperate times, such as fasting, or muscle wasting that afflicts cancer or AIDS patients, the body cannibalizes itself, atrophying and breaking down skeletal muscle proteins to liberate amino acids. In a new study published online June 8 and in the June 15, 2009 print issue of the Journal of Cell Biology (www.jcb.org), Shenhav Cohen, Alfred Goldberg, and colleagues show that muscle atrophy is a more ordered process than was previously thought. These researchers find evidence that enzyme MuRF1 selectively degrades the thick filaments in muscle, while bypassing the thin filaments.

We depend on skeletal muscles because they can produce movement, but they serve another purpose too. "Skeletal muscle is a protein reservoir that can be mobilized in times of need," says Goldberg. The structural core of a muscle cell is the myofibril, composed of myosin-containing thick filaments and actin-containing thin filaments. During atrophy, this structure is disassembled, but exactly how was not known. MuRF1, an atrophy-related gene, is a ubiquitin ligase that "ubiquitylates," or tags a protein, by attaching a ubiquitin molecule, marking it for degradation by the cell. It was unclear when and how ubiquitylation was involved in disassembling skeletal muscles. The researchers triggered atrophy in mice containing defective MuRF1 (lacking its RING-finger domain crucial for ubiquitylation). These mutant mice break down less muscle than wild-type mice, and less ubiquitylation takes place in the mutants.

Cohen and colleagues found that MuRF1 targets the thick filament, demolishing various components in a specific order. The researchers hypothesize that removal of certain thick filament components first permits subsequent MuRF1 access to the myosin heavy chain. However, MuRF1 doesn't exert the same power over the thin filament, which began to come apart even when MuRF1 was absent.

"Up to now, people thought the
'/>"/>

Contact: Rita Sullivan
news@rupress.org
212-327-8603
Rockefeller University Press
Source:Eurekalert

Page: 1 2

Related biology news :

1. Muscle mass: Scientists identify novel mode of transcriptional regulation during myogenesis
2. Pittsburgh scientists identify human source of stem cells with potential to repair muscle
3. Massive microRNA scan uncovers leads to treating muscle degeneration
4. Mechanism for regulation of growth and differentiation of adult muscle stem cells is revealed
5. How molecular muscles help cells divide
6. An ambulance man for muscle damage
7. Stem-cell transplantation improves muscles in MD animal model, UT Southwestern researchers report
8. Long-term use of mechanical ventilation contributes to the deterioration of human diaphragm muscle
9. RING finger protein 5 may guide treatment for muscle disease in older adults
10. Ibuprofen or acetaminophen in long-term resistance training increases muscle mass/strength
11. Pitt and University of Chicago researchers uncover process behind heart muscle contraction
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... heard of the water window? It consists of radiations ... not absorbed by the water in biological tissues. New ... coherent radiations within the water window. These could be ... high-contrast image of the biological samples or to be ... identifies the physical mechanism needed to efficiently generate the ...
(Date:8/21/2014)... RUSTON, La. A team of researchers ... innovative method for using affordable, consumer-grade 3D ... implants that can contain antibacterial and chemotherapeutic ... team comprised of doctoral students and research ... nanosystems engineering programs collaborated to create filament ...
(Date:8/20/2014)... E. Fox, a John and Rebecca Moores Professor of Biology ... a fellow in the International Society for the Study of ... of four members two from the U.S., one from ... 2014. Fellows are elected every three years, and 36 have ... more than 20 countries, the ISSOL includes researchers from disciplines ...
Breaking Biology News(10 mins):Water window imaging opportunity 2Louisiana Tech University researchers use 3D printers to create custom medical implants 2Louisiana Tech University researchers use 3D printers to create custom medical implants 3UH professor named fellow by International Astrobiology Society 2
... (ESA) will present its fifth annual Regional Policy Award ... during the Society,s upcoming conference in Portland, Oregon. The ... who has an outstanding record of informing political decision-making ... present this prestigious award to Ken Bierly for his ...
... (Boston) A recent study led by Boston University School ... plays a significant role in the regulation of high fat, ... which are published online in PLoS ONE , also ... type 2 diabetes. Katya Ravid, DSc/PhD, professor of ...
... Institution (WHOI) researchers have partnered with two companies ... WHOI: the Imaging FlowCytobot, an automated underwater microscope, ... light to provide wireless transmission of data, including ... WHOI biologists Robert Olson and Heidi Sosik, creators ...
Cached Biology News:Ken Bierly of the Oregon Watershed Enhancement Board to receive ESA Regional Policy Award 2Ken Bierly of the Oregon Watershed Enhancement Board to receive ESA Regional Policy Award 3BUSM study identifies receptor's role in regulating obesity, type 2 diabetes 2WHOI scientists/engineers partner with companies to market revolutionary new instruments 2WHOI scientists/engineers partner with companies to market revolutionary new instruments 3WHOI scientists/engineers partner with companies to market revolutionary new instruments 4
(Date:8/22/2014)... published today (August 22nd), in the scientific journal ... Neuroscience Programme establish the effect of serotonin on ... genetic and optical techniques., "Serotonin is a small ... range of brain functions, from the control of ... emotional behaviours, This neurotransmitter is also popularly thought ...
(Date:8/22/2014)... 22, 2014 Research and Markets ... China Gel Permeation Chromatography (GPC) Industry Report 2014" ... and China Gel Permeation Chromatography (GPC) Industry Report is ... of the global gel permeation chromatography industry with a ... a basic overview of the industry including definitions, classifications, ...
(Date:8/22/2014)... Greenville, SC (PRWEB) August 22, 2014 ... that indisputable acknowledgement is a national disgrace. Furthermore, ... part in establishing the current, deplorable state of ... outlined "5 great mistakes," to merely serve as ... convey the extent of colossal failure(s) that have ...
(Date:8/21/2014)... 2014 2014 Deep Research ... a professional and in-depth research report on ... basic Seaweed Fertilizer information, including Seaweed Fertilizer ... as well as industry overview. This research ... market as well as global industry analysis ...
Breaking Biology Technology:From happiness to pain: Understanding serotonin's function 2Global and China Gel Permeation Chromatography (GPC) Industry Report 2014 25 Great Mistakes in Healthcare and How to Fix Them by Dr. Ira Williams 2Internationals Seaweed Fertilizer Industry 2014 Development Trend Analysis in New Research Study at DeepResearchReports.com 2Internationals Seaweed Fertilizer Industry 2014 Development Trend Analysis in New Research Study at DeepResearchReports.com 3
... Therapeutics,Inc. (Nasdaq: CVTX ) today reported financial results for ... For the quarter ended December 31, 2007, the Company reported ... compares to a net loss of,$68.1 million, or $1.18 per ... $0.58 per share, for the prior quarter ended September 30,2007. ...
... MANASQUAN, N.J., Feb. 26 BioSpace, the world,s ... career fair company,welcomed over 900 biotechnology and pharmaceutical ... Massachusetts on February 19, 2008., Thirty-six bioscience ... thoroughly impressed with the quality as well as ...
... Microsoft Gold Certified Partner Provides Framework, for ... Solutions, ORLANDO, Fla., Feb. 26 ... software and services for health and,human services ... Certified Partner status in the Microsoft Partner ...
Cached Biology Technology:CV Therapeutics Reports 2007 Fourth Quarter and Full Year Financial Results 2CV Therapeutics Reports 2007 Fourth Quarter and Full Year Financial Results 3CV Therapeutics Reports 2007 Fourth Quarter and Full Year Financial Results 4CV Therapeutics Reports 2007 Fourth Quarter and Full Year Financial Results 5CV Therapeutics Reports 2007 Fourth Quarter and Full Year Financial Results 6CV Therapeutics Reports 2007 Fourth Quarter and Full Year Financial Results 7CV Therapeutics Reports 2007 Fourth Quarter and Full Year Financial Results 8BioSpace Boston Career Fair Attracts over 900 Bioscience Candidates 2Netsmart Technologies Announces Development Program on Microsoft for Local Public Health Clinic Management and Vital Records Software 2Netsmart Technologies Announces Development Program on Microsoft for Local Public Health Clinic Management and Vital Records Software 3
... is pleased to offer the ATTO-TAG ... detection of primary amines. Developed by ... the ATTO-TAG reagents are similar to ... (NDA) and anthracene-2,3-dicarboxaldehyde, all of which ...
...
...
Human Cystatin A MAb (Clone 224705)...
Biology Products: